[1P-0415] Development of in vitro and in cell screening systems for PROTACs-dependent protein interaction

○Saya Matsuoka¹, Satoshi Yamanaka¹, Tatsuya Sawasaki¹ (1.Div. of Cell-Free Sci., PROS, Ehime Univ.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[1P-0416] An IMiD-induced SALL4 degron system for selective degradation of target proteins

○Yuki Shoya¹, Satoshi Yamanaka¹, Hisayo Nishida-Fukuda², Norio Shibata³, Tatsuya Sawasaki¹ (1.Div. of Cell-Free Sci., PROS, Ehime Univ., 2.Dept. of Genome Editing, Inst. of Biomed. Sci., Kansai Medical Univ., 3.Dept. of Nanopharmaceutical Sci., Nagoya Institute of Technology)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[1P-0417] Evaluation of the Property of a Cyclic Pyrrole-Imidazole Polyamide Conjugated with a DNA Alkylating Agent

○Yuki Hirose¹, Kaori Hashiya¹, Toshikazu Bando¹, Hiroshi Sugiyama^1,2 (1.Dept. of Chem., Grad. Sch. of Sci., Kyoto Univ., 2.iCeMS, Inst. for Adv. Stud., Kyoto Univ.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[1P-0418] Iron isotopic composition of iron supplements

○Yuko Yamagata^1,5, Takayuki Ichinose², Takafumi Hirata³, Tetsuya Ishikawa⁴, Akihiro Matsunaga^4,5, Mari Shimura^4,5 (1.Biostruct. Mechanism Labo., RIKEN SPring-8 Ctr., 2.Inorg. Anal. Labo., Toray Res. Ctr. Inc., 3.Geochem. Res. Ctr., The Univ. of Tokyo, 4.RIKEN SPring-8 Ctr., 5.Dept. Intractable Diseases, Res. Inst., Nat. Ctr. Global Health & Med.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[1P-0419] In vivo suppression of pancreatic tumour by targeting KRAS mutations using CANDDY technology

○Satoshi Imanishi¹, Lijuan Huang¹, Shoko Itakura¹, Megumi Saito^1,3, Megumi Tsukamoto^1,3, Masamichi Ishizaka^1,3, Tmohiro Yamaguchi^1,3, Yoichi Iwasaki^1,3, Etsuko Miyamoto-Sato^1,2,3 (1.M-S. Mol. Med. Sci. Lab., Tokyo Univ. of Sci., 2.Res. Inst. for Biomed. Sci., Tokyo Univ. of Sci., 3.R&D Dep., FuturedMe Inc.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[1P-0420] Verification of “CANDDY” technology - a novel approach for next-generation molecular target drug

○Lijuan Huang¹, Satoshi Imaishi¹, Shoko Itakura², Megumi Tsukamoto^1,3, Etsuko Miyamoato-Sato^1,2,3 (1.EM-S Mol. Med. Sci. Lab., Res. Inst. for Sci. & Tech., Tokyo Univ. of Sci. , 2.Grad. Sch. of Biol. Sci., Res. Inst. for Biomed. Sci., Tokyo Univ. of Sci. , 3.R&D Dept., FuturedMe Inc.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[1P-0421] Virucidal activities of sucrose octasulfate in the presence of proteins

Keiko Ikeda¹, Tamiko Nagao², Sayuri Nagashima³, Mitsunori Nishide⁴, Tomomi Kuwahara³, Takahiko Mitani⁵, Tsutomu Arakawa⁶, ○A. Hajime Koyama^1,3 (1.Sch. Health & Nursing Sci, Wakayama Medical Univ., 2.Dept. Sci. for Human Health, Shikoku Univ. Jr Coll., 3.Dept. Mol. Microbiol., Fac. Med., Kagawa Univ., 4.Dept. Nutrition, Wakayama Shin-Ai Women's Jr. Coll., 5.Res. Center for Food & Agricult. Wakayama Univ., 6.Alliance Protein Lab.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[1P-0422] Decomposition profile data analysis identifies unrecognized multiple effects of a natural product, Rescinnamine.

○Shumpei Nemoto¹, Tadahaya Mizuno¹, Katsuhisa Morita¹, Hiroyuki Kusuhara¹ (1.Dept. of Pharm Sci., Grad. Sch. of Pharm Sci., Univ. of Tokyo)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[1P-0423] Exploration of RNA modifications to potentiate mRNA medicine

○Kento Tsumura¹, Shinichiro Akichika¹, Yuma Ishigami¹, Tsutomu Suzuki¹ (1.Dept. of Chem. & Biotech., Sch. of Eng., Univ. of Tokyo)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[1P-0424] Photocontrolled mechanical switching of DNA nanostructure to affect cell morphology

○Soumya Sethi¹, Tomoko Emura¹, Kumi Hidaka¹, Hiroshi Sugiyama^1,2, Masayuki Endo^1,2 (1.Department of Chemistry, Graduate School of Science Kyoto University, 2.Institute for Integrated Cell-Material Sciences Kyoto University)

The 43rd Annual Meeting of the Molecular Biology Society of Japan