[3PW-11-1] A neomorphic inhibitor secreted from pecanex mutant phagocytes remotely suppresses Notch signaling

○Tomoko Yamakawa¹, Kenji Matsuno¹ (1.Dept. of Biol. Sci., Grad. Sch. of Sci., Osaka Univ.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 4, 2020 3:30 PM - 3:45 PM

[3PW-11-2] Transmembrane 2 domain containing 3 (TM2D3) regulates presentation of Notch receptors on the cell surface

○Motoo Kitagawa^1,2,8, Wataru Masuda^3,8, Tomoko Yamakawa⁴, Rieko Ajima⁵, Katsuya Miyake⁶, Takumi Itabashi⁷, Toshifumi Umemiya^7,8, Kazuhiko Azuma⁸, Jun-ichi Tamaru³, Makoto Kiso⁵, Puspa Das⁴, Yumiko Saga⁵, Kenji Matsuno⁴ (1.Dept. of Biochem., Intl. Univ. of Health and Welfare Sch. of Med., 2.Dept. of Basic Med. Sci., Intl. Univ. of Health and Welfare Grad. Sch. of Med., 3.Dept. of Pathol., Saitama Med. Cent., Saitama Medical Univ., 4.Dept. of Biol. Sci., Grad. Sch. of Sci., Osaka Univ., 5.Mammalian Dev. Lab., Dept. of Gene Function and Phenomics, Natl. Inst. of Genet., 6.Cntr. for Basic Med. Res., Narita Campus, Intl. Univ. of Health and Welfare, 7.Intl. Univ. of Health and Welfare Grad. Sch. of Health and Welfare Sci., 8.Dept. of Mol. Tumor Pathol., Chiba Univ. Grad. Sch. of Med.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 4, 2020 3:45 PM - 4:05 PM

[3PW-11-3] Notch dynamics regulate temporal patterning of neurogenesis in the developing fly brain

○Tetsuo Yasugi¹, Miaoxing Wang¹, Xujun Han¹, Chuyan Liu¹, Rie Takayama¹, Makoto Sato¹ (1.Infiniti, Kanazawa Univ.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 4, 2020 4:05 PM - 4:25 PM

[3PW-11-4] Gene expression dynamics regulate the timing of down-regulation of Notch signaling and neuronal differentiation

○Hiromi Shimojo¹, Ryoichiro Kageyama² (1.Grad. Sch. of Front. Biosci., Osaka Univ., 2.Inst. for Front. Life & Med. Sci., Kyoto Univ.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 4, 2020 4:25 PM - 4:40 PM

[3PW-11-5] Coupling delay in Delta-Notch signaling controls synchronized oscillation in the segmentation clock

○Kumiko Yoshioka-Kobayashi^1,2,3, Marina Matsumiya^1,4,5, Yusuke Niino⁶, Akihiro Isomura^1,7,8, Hiroshi Kori⁹, Atsushi Miyawaki^6,10, Ryoichiro Kageyama^1,2,4,8 (1.Infront, Kyoto Univ., 2.Grad. Sch. of Med., Kyoto Univ., 3.ASHBi, Kyoto Univ., 4.Grad. Sch. of Biostu., Kyoto Univ., 5.EMBL, Barcelona, 6.Cent. for Brain Sci., Riken, 7.PREST, JST, 8.iCeMS, Kyoto Univ., 9.Grad. Sch. of Front. Sci.,Univ. of Tokyo, 10.Cent. for Adv. Photon., Riken)

The 43rd Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 4, 2020 4:40 PM - 5:00 PM

[3PW-11-6] Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice

○Katsuto Hozumi¹ (1.Dept. of Immunol., Tokai Univ. Sch. of Med.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 4, 2020 5:00 PM - 5:20 PM

[3PW-11-7] Structural basis of Notch recognition by human gamma-secretase.

○Rui Zhou¹, Guanghui Yang¹, Qiang Zhou^1,2, Xuefei Guo¹, Chuangye Yan¹, Meng Ke¹, Jianlin Lei^1,3, Yigong Shi^1,2 (1.Beijing Advan. Innovation Center for Structural Biol., Tsinghua-Peking Joint Center for Life Sci., Sch. of Life Sci., Tsinghua Univ., Beijing, China, 2.Institute of Biol., Westlake Institute for Advanced Study, Hangzhou, China., 3.Technology Center for Protein Sciences, Ministry of Education Key Laboratory of Protein Sciences, Sch. of Life Sci., Tsinghua Univ., Beijing, China.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 4, 2020 5:20 PM - 5:40 PM

[3PW-11-Discussion~Conclusion] Discussion~Conclusion

○Hiromi SHIMOJO¹ (1.Osaka University)

The 43rd Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 4, 2020 5:40 PM - 5:45 PM

[3PW-12-1] Transcriptional and post-transcriptional regulation under hypoxic conditions

○Koh Nakayama¹, Mikako Ito², Kinji Ohno², Fumihiko Hakuno³, Shin-Ichiro Takahashi³, Naoyuki Kataoka³ (1.Parmacol., Sch. of Med., Asahikawa Med. Univ., 2.Neurogene., Grad. Sch. of Med., Nagoya Univ., 3.Grad. Sch. of Agr., Univ. of Tokyo)

The 43rd Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 4, 2020 3:30 PM - 3:45 PM

[3PW-12-2] PI3-kinase related kinase SMG1 and DNA-PK directly phosphorylate and regulate NRF2 in an oxidative stress response pathway.

○Akio Yamashita¹ (1.Dept.Mol.Biol., Sch. of Med., Univ. Yokohama City)

The 43rd Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 4, 2020 3:45 PM - 4:05 PM