[1SP-10-11_1P-820] Analysis of the mechanisms of dedifferentiation and malignant phenotype in breast cancer cells induced by hydrogel

^○Jun Suzuka¹, Sumito Saeki^2,3, Kohei Kumegawa¹, Ai Tsuchiya^2,4, Takayuki Ueno^1,3, Masumi Tsuda^5,6, Jian Ping Gong^6,7, Shinya Tanaka^5,6, Reo Maruyama^1,2 (1.Cancer Cell Diversity Project, NEXT-Ganken Prog., JFCR, 2.Project Cancer Epigenome, The Cancer Inst., JFCR, 3.Breast Oncol. Center, Cancer Inst. Hosp., JFCR, 4.Dept. of Breast Surg., Sch. of Med., Kyorin Univ., 5.Dept. of Cancer Pathol., Fac. of Med., Hokkaido Univ., 6.Inst. for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido Univ., 7.Soft & Wet Matter Sci., Dept. of Adv. Transdisciplinary Sci., Fac. Of Adv. Life Sci., Hokkaido Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 2:15 PM - 2:18 PM

[1SP-10-12_1P-836] NCYM, a human de novo evolved gene product, promotes tumorigenesis in a mouse cholangiocarcinoma organoid model

^○Kazuma Nakatani^1,2, Daisuke Muto^1,2, Akiko Endo², Hiroyuki Kogashi^2,1, Hidefumi Suzuki³, Hidehisa Takahashi³, Yoshitaka Hippo^4,1, Yusuke Suenaga² (1.Grad. Sch. of Medical and Pharmaceutical. Sci., Chiba Univ., 2.Lab. of Evolutionary Oncology, Chiba Cancer Cent. Res. Inst., 3.Dep. of Molecular Biology, Yokohama City Univ. Grad. Sch. of Medical Sci., 4.Lab. of Precision Tumor Model Systems, Chiba Cancer Cent. Res. Inst.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 2:18 PM - 2:21 PM

[1SP-10-13_1P-842] Investigation of the main factors affecting protoporphyrin IX accumulation of tumor cells in photodynamic diagnosis using aminolevulinic acid

^○Saki Kasai (Dept. of Sci. Technol., Univ. of Tokyo tech)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 2:21 PM - 2:24 PM

[1SP-10-14_1P-846] Understanding of epigenomes during medulloblastoma formation identifies a novel potential therapeutic target Fosl2

^○Maho Jingu^1,2, Wanchen Wang^1,6, Kohei Kumegawa³, Ryo Shiraishi^1,7, Owen Chapman⁴, Mikio Hoshino¹, Masaki Sone², Lukas Chavez⁴, Reo Maruyama^3,5, Daisuke Kawauchi¹ (1.Dept. of Biochem. and Cell. Biol., NCNP, Tokyo, Japan, 2.Grad. Sch. of Sci., Toho Univ., Funabashi, Japan, 3.Cancer Cell Diversity Project, NEXT-Ganken Program, JFCR, Tokyo, Japan, 4.Dept. of Med., UCSD, La Jolla, California, 5.Project for Cancer Epigenomics, Cancer Inst., JFCR, Tokyo, Japan, 6.Grad. Sch. of Med. and Dent. Sci., TMDU, Tokyo, Japan, 7.JSPS Research Fellowship for Young Scientists, Post doctoral Fellow)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 2:24 PM - 2:27 PM

[1SP-10-15_1P-832] Mechanistic analysis of indoxyl sulfate induced the proliferation of HCT-116 cells focusing on β-catenin

^○Yu Ichisaka¹, Syozo Yano², Toshimitsu Niwa³, Hidehisa Shimizu¹ (1.Grad. Sch. Nat. Sci. Tech., Shimane Univ., 2.Dept. Lab. Med., Fac. Med., Shimane Univ., 3.Shubun Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 2:27 PM - 2:30 PM

[1SP-10-16_1P-824] Functional analysis of miR-5787 in prostate cancer progression by adipocyte secretions.

^○Mizuki Nakahama¹, Haruka Takahashi¹, Masatoshi Watanabe², Kazutoshi Iijima³ (1.Grad. Sch. of Sci., Yokohama Natl. Univ., 2.Dept. Oncol. Pathol., Sch Med., Mie Univ., 3.Fac. Eng,. Yokohama Natl. Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 2:30 PM - 2:33 PM

[1SP-10-17_1P-830] Mechanism through which nucleus dynamics in pancreatic cancer cells induced by hydrostatic pressure

^○Norino Uenaka, Daisuke Yoshino (Dept. of Biomed. Eng. , Grad. Sch. of Eng., Tokyo Univ. of Agric. Technol.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 2:33 PM - 2:36 PM

[1SP-10-18_1P-822] Cellular growth activity depending on the histone H2A O-GlcNAc system in triple negative breast cancer

^○Yoko Uno, Koji Hayakawa (Fac. of　Vet. Med., Okayama Univ. of Sci.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 2:36 PM - 2:39 PM

[1SP-11-01_1P-838] Elucidation of the mechanism of cancer therapy resistance acquisition using single-cell multi-omics technology

^○Haga Yasuhiko, Ayako Suzuki, Masahide Seki, Yutaka Suzuki (Grad. Sch. of Front. Sci., Univ. of Tokyo)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 1:45 PM - 1:48 PM

[1SP-11-02_1P-844] Functional analysis of mutant CDH1 in invasive lobular carcinoma.

^○Kazushi Azuma¹, Jun Nakayama^2,3, Kentaro Semba^4,1 (1.1Dept. Life Sci. & Biomed. Sci., Grad. Sch. of Sci. & Eng., Waseda Univ., 2.Lab. of Integr. Oncol., Natl. Cancer Ctr. Res. Inst., 3.Dept. of Oncogenesis Growth Regulation, Res Inst., Osaka Intl. Cancer Inst., 4.TR Ctr., Fukushima Med. Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 1:48 PM - 1:51 PM