[3AS-16-05] High-throughput single cell multi-epigenomic profiling using chromatin integration labelling-sequence

^○Akihito Harada¹, Takeru Fujii¹, Kazumitsu Maehara¹, Hiroshi Kimura², Yasuyuki Ohkawa¹ (1.Div. of Transcriptomics, MIB, Univ. of Kyushu, 2.Institute of Innovative Research, Tokyo Institute of Tech.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 8, 2023 10:50 AM - 11:09 AM

[3AS-16-06_3P-161] Elucidation of a spatial relationship between higher-order genomic structures and clusters of transcriptional regulatory factors in transcriptional bursting

^○Hiroaki Ohishi¹, Soya Shinkai², Hitoshi Owada^1,3, Shuichi Onami², Takashi Yamamoto³, Yasuyuki Ohkawa⁴, Hiroshi Ochiai¹ (1.Div. of Gene Expression Dynamics, MIB, Kyushu Univ., 2.BDR, RIKEN, 3.Graduate School of Integrated Sciences for Life, Hiroshima Univ., 4.Div. of Transcriptomics, MIB, Kyushu Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 8, 2023 11:09 AM - 11:21 AM

[3AS-16-07_3P-633] Functional antagonism between PRDM14 and POU3F1 regulates the transition between naïve and formative pluripotency

^○TAKEHARU OKUDA, YOSHIYUKI SEKI (Dept.of Biomed., Grad. Sch. of Scitech., KG. Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 8, 2023 11:21 AM - 11:33 AM

[3AS-16-08_3P-146] Pcgf6 counteracts Dppa2/4 to epigenetically primes de novo DNA methylation target genes in naïve pluripotency for developmental fidelity

^○Mitsuhiro Endoh¹, Masaki Okano¹, Haruhiko Koseki², Hitoshi Niwa¹ (1.Dept. of Pluripotent Stem Cell Biol., IMEG, Univ. of Kumamoto, 2.Lab. for Developmental Genetics, RIKEN IMS)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 8, 2023 11:33 AM - 11:45 AM

[3AS-17-Introduction] Introduction

^○Yuzuru Imai (Juntendo Universit)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 8, 2023 9:30 AM - 9:31 AM

[3AS-17-01] Regulation of lysosomal positioning by LRRK2, a protein kinase responsible for Parkinson’s disease

^○Genta Ito^1,2, Kyohei Ito³, Miho Araki³, Yuta Katai⁴, Yuki Nishimura⁴, Sota Imotani⁴, Haruki Inoue⁴, Naoko UtsunomiyaTate¹, Taisuke Tomita^2,3 (1.Faculty of Pharma-Sciences, Teikyo Univ., 2.Social Cooperation Program of Brain Neurol. Disord., Grad. Sch. of Pharm. Sci., Univ. of Tokyo, 3.Lab. Neuropathol. Neurosci., Grad. Sch. of Pharm. Sci., Univ. of Tokyo, 4.HACARUS, Inc.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 8, 2023 9:31 AM - 9:50 AM

[3AS-17-02] α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate pathological features of Lewy body diseases in mice

^○Norihito Uemura (Dept. of Neurol., Grad. Sch. of Med., Kyoto Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 8, 2023 9:50 AM - 10:09 AM

[3AS-17-03] Novel vaccines based on the three-dimensional structure of alpha-synuclein aggregates

^○Takashi Nonaka (Dementia PJ, Tokyo Metropolitan Institute of Medical Science)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 8, 2023 10:09 AM - 10:28 AM

[3AS-17-04_3P-725] Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson’s disease caused by CHCHD2 gene mutations

^○Satoru Torii¹, Satoko Arakawa², Shigeto Sato³, Keiichi Ishikawa^3,4, Daisuke Taniguchi³, Hajime Sakurai⁵, Shinya Honda¹, Yuuichi Hiraoka^6,7, Masaya Ono⁸, Wado Akamatsu⁴, Nobutaka Hattori³, Shigeomi Shimizu¹ (1.Dept. of Pathol. Cell Biol., Med. Res. Inst., Tokyo Med. Dent. Univ., 2.Res. Core Cent., Tokyo Med. Dent. Univ., 3.Dept. of Neurol., Sch. of Med., Juntendo Univ., 4.Cent. for Gen. Reg. Med., Juntendo Univ., 5.Dept. of Mol. Biochem., Grad. Sch. of Life Sci., Univ. of Hyogo, 6.Lab. of Mol. Neuro., Med. Res. Inst., Tokyo Med. Dent. Univ., 7.Lab. of Gen. Edit. for Biomed. Res., Med. Res. Inst., Tokyo Med. Dent. Univ., 8.Dept. of Clin. Proteo., Nat. Can. Cent. Res. Inst.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 8, 2023 10:28 AM - 10:47 AM

[3AS-17-05] Photooxygenation for tau as a new therapeutic strategy against tauopathy

^○Yukiko Hori¹, Youhei Sohma^2,3, Makoto Higuchi⁴, Motomu Kanai², Taisuke Tomita¹ (1.Lab. of Neuropathol. and Neurosci., Grad. Sch. of Pharm. Sci., Univ. of Tokyo, 2.Lab. of Synth. Org. Chem., Grad. Sch. of Pharm. Sci., Univ. of Tokyo, 3.Dept. of Med. Chem., Sch. of Pharm. Sci., Wakayama Medical Univ., 4.Dept. of Functional Brain Imaging, QST)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Fri. Dec 8, 2023 10:47 AM - 11:06 AM