[3P-789] Establishment of a human iPS cell-derived senescent cardiomyocyte model by regulating endogenous ROS production

^○Sugako Oka¹, Li Jun², Wang Yuanli², Noriko Takano¹, Mizuki Ohno¹, Lee JongKook², Kyoko Hidaka^1,3 (1.Dept. of Med. Biophysi. and Radiat. Biol. Fac. of Med. Sci. Kyushu Uni., 2.Dept. of Cardiov. Regen. Med., Osaka Uni. Grad. Sch. of Med., 3.Cent. for Fundam. Edu. Uni. of Kitakyushu)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-790_3SP-09-14] STEAP3 induces apoptosis in senescent cells dependent on intracellular Fe2+ and FAD

^○Tatsuki Iwamoto², Taiki Nagano¹, Tetsushi Iwasaki^2,1, Shinji Kamada^2,1 (1.Biosignal Research Center, Kobe University, Kobe, Japan, 2.Department of Biology, Graduate School of Science, Kobe University)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-791] Decoding Aging in Post-Mitotic Cells: A Focus on snoRNAs and Mitochondrial Gene Expression in Aged Mouse Cardiomyocytes by Transcriptome Analysis

^○Yasuhiro Takenaka^1,2, Masataka Hirasaki³, Ikuo Inoue², Masaaki Ikeda⁴, Hisayuki Ohata⁵, Yoshihiko Kakinuma¹ (1.Dept. of Bioregulatory Sci., Nippon Med. Sch., 2.Dept. of Diabetes and Endocrinol., Saitama Med. Univ., 3.Dept. of Clinical Cancer Genomics, Saitama Med. Univ., 4.Dept. of Physiol., Saitama Med. Univ., 5.Div. of Lab. Animal Sci., Nippon Med. Sch.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-792_3SP-09-18] Analysis of the mechanism of SASP induction by epigenetic abnormalities in noncoding DNA regions

^○Kenichi Miyata^1,2,3, Akiko Takahashi^2,3, Reo Maruyama^1,4 (1.Project for Epigenomics, Cancer Inst., JFCR, 2.Div. of Cell. Senescence, Cancer Inst., JFCR, 3.Project for Cell Commun., NEXT, JFCR, 4.Project for Cell Diversity, NEXT, JFCR)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-793] A complement study on the life of the B10 mouse

^○Kimihiko Sugaya (Dept. of Mol. Imaging and Theranostics, QST)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-794_3SP-09-17] The effects of juvenile housing conditions (single- and group-housing) on growth speed and lifespan in African turquoise killifish.

^○Chika Takahashi¹, Emiko Okabe¹, Masanori Nono¹, saya Kishimoto¹, Hideaki Matsui², Tohru Ishitani³, Takuya Yamamoto^5,4, Masaharu Uno¹, Eisuke Nishida¹ (1.RIKEN BDR, 2.Brain Res. Inst., Niigata Univ., 3.Inst. for Microbial Diseases, Osaka Univ., 4.Inst. Adv. Study Human Biol. WPI ASHBi,Kyoto Univ., 5.Center for iPS Cell Res. and Application (CiRA), Kyoto Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-795_3AS-13-08] Mitochondria stress response induced ATF4 activation associated with nuclear deformation resulted in age-related bone loss

^○Kenji Watanabe¹, Shuichi Shibuya¹, Hidetoshi Nojiri², Takahiko Shimizu¹ (1.Aging Stress Resp. Res. P.T., NCGG, 2.Dept. of Med. Orthop. and Motor Organ, Juntendo Univ. Grad. Sch. of Med.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-796_3SP-09-16] Elucidation of the mechanisms underlying muscle integrity supported by heterogeneity of mesenchymal progenitors

^○Yuka Hasegawa¹, Madoka Uezumi², Shinichiro Hayashi³, Satoru Noguchi³, Ichizo Nishino³, Tamaki Kurosawa⁴, Takeshi Nikawa¹, Akiyoshi Uezumi² (1.Dept. of Nutr. Physiol., Inst. of Biomed. Sci., Grad school of Tokushima Univ., 2.Div. of Cell Hetero., Med. Inst. of Bioreg., Kyushu Univ., 3.Dept. of Neuromuscul. Res., Natl. Inst. of Neurosci., NCNP, 4.Dept. of Vet. Pharmacol., Grad School of Agric.and Life Sci., Univ. of Tokyo)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-797] Impact of cellular senescence in skin aging and pursuing its physiological significance

^○TANENOBU HARADA¹, Yuma Sugiyama¹, Yu Aoki², Keiko Tsuji², Daijirou Sugiyama², Mitsuo Maruyama^1,3 (1.DII., GSRC., NCGG, 2.DSHC, 3.Dept.Aging., Grad. Sch. Med., Nagoya Univ)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-798_3SP-09-15] Isolation of multicopy suppressor genes of the short replicative lifespan caused by increasing cytosolic polyphosphate in budding yeast

^○Chiharu Umeda, Yukio Mukai (Grad. Sch. of Biosci., Nagahama Inst. of Bio-Sci. and Tech.)

The 46th Annual Meeting of the Molecular Biology Society of Japan