[2P-0570] Development of bispecific antibody drug for mesothelioma therapy

〇Yuki Kanamori^1,2, Yasuhiro Moriwaki², Shinako Takimoto¹, Hidemi Misawa², Kohzoh Imai¹, Shoutaro Tsuji¹ (1.Res Inst, Kanagawa Cancer Ctr, 2.Div Pharmacol, Dept Pharm, Keio Univ)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2P-0571] Anti-CD26 Humanized Monoclonal Antibody Conjugated to Triptolide Inhibits Tumor Cell Growth via Transportation into Nucleus and Impaired RNA Polymerase II

〇Mutsumi Hayashi¹, Hiroko Madokoro¹, Taketo Yamada² (1.Dept. of Pathol., Sch. of Med., Keio Univ., 2.Dept. of Pathol., Sch. of Med., Saitama Med. Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2P-0572] Targeting immune checkpoint related gene expression by pyrrole imidazole polyamide compounds

〇Mayu Shinohara^1,2, Atsushi Takatori³, Yoshinao Shinozaki¹, Nobuko Koshikawa¹, Takayoshi Watanabe³, Jason Lin¹, Osamu Shimozato⁴, Hiroki Nagase¹ (1.Div.Cancer Genet., Chiba Cancer Ctr. Res. Inst., 2.Grad. Sch. Med. &Pharm. Sci., Chiba Univ, 3.Div. Innovative Cancer Therap., Chiba Cancer Ctr. Res. Inst., 4.Lab. Tumor Genome., Chiba Cancer Ctr. Res. Inst.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2P-0573] Screening of molecular pathways that contribute to escape of cancer cells from PD-1/PD-L1 immunotherapy

〇Kanae Yumimoto¹, Keiichi I. Nakayama¹ (1.Dept. of Mol. Cell. Biol., Med. Inst. Bioreg., Kyushu Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2P-0574] Expression change of immune checkpoint related molecule in cancer cells After C-ion irradiation

〇Fuki Kurosawa^1,2, Lin Xie², Masayuki Hanyu², Mingrong Zhang², Shingo Fujisaki¹, Takashi Shimokawa^1,2 (1.Dept. of bio molecular. Sci., Grad. Sch. of Sci., Univ. of Toho, 2.NIRS, QST)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2P-0575] cGAS-STING triggers radiotherapy-induced immune response in esophageal cancer cells

〇Junyan Du^1,4, Shun-ichiro Kageyama², Akihiro Ohashi³, Katsuya Tsuchihara^1,4 (1.Dept. of Integ. Biosci., Grad. Sch. of Frontier Sci., Univ. of Tokyo, 2.Div. of Partical Therapy, East Hospital, Natl.Cancer Ctr., 3.Div. of Translational Genomics, EPOC, Natl.Cancer Ctr., 4.Div. of Translational Informatics, EPOC, Natl.Cancer Ctr.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2P-0576] ASK1 regulates tumor metastasis in an NK cell-dependent manner

〇Makoto Fujimoto¹, Miki Kamiyama¹, Isao Naguro¹, Hidenori Ichijo¹ (1.Cell Signaling, Grad. Sch. Pharmaceut. Sci. Univ. of Tokyo)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2P-0577] Interleukin 18 induced chemokines suppress cancer metastasis

〇Naoko Yamada¹, Madoka Hirayama¹, Nobuyuki Terada¹ (1.Dept. of Patho., Hyogo Col. of Med. )

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2P-0578] IMiDs mediated growth suppression of hematological malignancies

〇Hidekatsu Iha¹, Emi Ikebe^1,2, Shunsuke Shimosaki³, Nichole Fife¹, Lindsay Fajardo¹, Mitsuo Hori⁴, Hiroo Hasegawa⁵, Naoki Hijiya⁶, Yoshiyuki Tsukamoto⁶, Masatsugu Moriyama⁶, Jiro Kikuchi⁷, Yusuke Furukawa⁷, Shotaro Hagiwara⁸, Masumichi Saito², Kazuhiro Morishita³ (1.Dept. Microbiol., Oita Univ. Facult. of Med., 2.Dept. Safety Res. Blood Biol. Products, Natl. Inst. Infect. Dis., 3.Tumor Cell Biochem., Dept. Med. Sci., Facult. Med., Univ. Miyazaki, 4.Dept. Hematol., Ibaraki Pref. Centl. Hosp., 5.Dept. Lab. Med., Nagasaki Univ. Grad. Sch. Biomed. Sci., 6.Dept. Mol. Pathol., Oita Univ. Facult. of Med., 7.Center Mol. Med., Jichi Med. Univ., 8.Dept. Hematol., Tokyo Women's Med. Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2P-0579] Blocking the generation of myeloid-derived suppressor cells (MDSCs) does not affect the cancer progression

〇Xuefeng Jing¹, Yukari Ikeda¹, Sachi Inada ¹, Akane Tabuchi ¹, Koji Tsuruta¹, Miki Esaka¹, Kazuki Matsumoto¹, Norimitsu Inoue¹ (1.Dept. of Mol. Genetics )

The 42nd Annual Meeting of the Molecular Biology Society of Japan