[2AW-07-3] Dimeric configuration of full-length human poly(ADP-ribose) polymerase 1 revealed by single particle electron microscopy

〇Masanao Miwa¹, Kenichi Kouyama¹, Kouta Mayanagi², Setsu Nakae¹, Yoshisuke Nishi¹, Tsuyoshi Shirai¹ (1.Nagahama Institute of BioScience and Technology, 2.Kyushu University)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 4, 2019 9:34 AM - 9:55 AM

[2AW-07-4] Essential roles of poly(ADP-ribose) polymerase in maintenance of neural stem/progenitor cells

〇Suguru Kurokawa¹, Akiko Okuda², Masanori Takehashi¹, Seigo Tanaka¹ (1.Pharm, Osaka Ohtani Univ., 2.Sch of Health Sci, Niigata Univ. Grad. )

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 4, 2019 9:55 AM - 10:16 AM

[2AW-07-5] Patients with a gene encoding a truncated ADP-ribosyl-acceptor hydrolase 3 exhibit a progressive neurodegenerative phenotype

〇Masato Mashimo^1,2, Xiangning Bu², Kazumasa Aoyama², Jiro Kato², Hiroko Ishiwata-Endo², Linda A. Stevens², Atsushi Kasamatsu^2,5, Lynne A. Wolfe³, Camilo Toro³, David Adams^3,4, Thomas Markello³, William A. Gahl^3,4, Joel Moss² (1.Dept. of Pharmacol., Fac. of Pharm. Sci., Doshisha Womens College, 2.Pulmonary Branch, NHLBI, NIH, 3.NIH Undiagnosed Diseases Program, Common Fund, Office of the Director, NIH, 4.Office of the Clinical Director, NHGRI, NIH, 5.Dept. of Oral Sci., Grad. Sch. of Med., Chiba Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 4, 2019 10:16 AM - 10:37 AM

[2AW-07-6] Function of PARP1 in transcriptional regulation

〇Mitsuko Masutani^1,2, Tomonori Araki^1,3, Yuka Sasaki^1,2, Takae Onodera^1,2, Shintaro Ookawa¹, Kazuhiko Nakao³, Yasufumi Murakami⁴, Hiroaki Fujimori^1,2 (1.Dept. Frontier Life Sci., Grad. Sch. Biomed. Sci., 2.Div. Cellular Sig. , 3.Dept. Gastro. and Hepatol. Grad. Sch. Biomed. Sci., 4.Dept. Biol. Sci. and Tech., Fac. Indust. Sci. Tech.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 4, 2019 10:37 AM - 10:58 AM

[2AW-07-7] New Mechanistic Insights into PARP1-mediated DNA Damage Response

〇Chengmin Qian¹, Si Xie¹, Oliver Mortusewicz², Hoi Tang Ma³, Patrick Herr², Randy YC Poon³, Thomas Helleday² (1.School of Biomedical Sciences, the University of Hong Kong, 2.Science for Life Laboratory, Karolinska Institutet, 3.Division of Life Science, Hong Kong University of Science and Technology)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 4, 2019 10:58 AM - 11:26 AM

[2AW-07-Discussion] Discussion

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 4, 2019 11:26 AM - 11:30 AM

[2AW-08-Introduction] Introduction

〇Kazuhiro Fukumura¹ (1.Fujita Health University)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 4, 2019 9:00 AM - 9:05 AM

[2AW-08-1] Regulation of R-loop formation and genome stability by ADAR1 RNA editing enzyme

Yusuke Shiromoto¹, Masayuki Sakurai¹, Moeko Minakuchi¹, Kentaro Ariyoshi¹, 〇Kazuko Nishikura¹ (1.Gene Expression & Regulation)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 4, 2019 9:05 AM - 9:25 AM

[2AW-08-2] SPF45/RBM17 is a novel constitutive splicing factor for a subset of human short introns

〇Kazuhiro Fukumura¹, Rei Yoshimoto¹, Tetsuro Hirose², Kunio Inoue³, Akila Mayeda¹ (1.Div. of Gene Exp., ICMS., Fujita Health Univ., 2.Inst. for Genet. Med., Hokkaido Univ., 3.Dept.of Biol. Sci., Grad. Sch. of Sci., Kobe Univ. )

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 4, 2019 9:25 AM - 9:45 AM

[2AW-08-3(4P-0171)] Homeostasis of S-adenosylmethionine (SAM) synthetase genes in C. elegans by alternative pre-mRNA splicing through m6A modification at the 3' spice site

Shotaro Wani¹, Eichi Watabe¹, Yuma Ishigami², Marina Togo-Ohno¹, Tsutomu Suzuki², 〇Hidehito Kuroyanagi¹ (1.Med Res Inst, Tokyo Med Dent Univ, 2.Grad Sch Eng, Univ Tokyo)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 4, 2019 9:45 AM - 10:05 AM