[2LBA-067] Is increased REM sleep an adaptive response or an exacerbating factor in depression?

〇Shinnosuke Yasugaki^1,2, Chih-Yao Liu^1,3, Mitsuaki Kashiwagi^1,4, Mika Kanuka¹, Takato Honda¹, Shingo Miyata⁵, Masashi Yanagisawa¹, Yu Hayashi¹ (1.WPI-IIIS, Univ. of Tsukuba, 2.Dept. of Biomed. Sci., Grad. Sch. of Comp. Hum. Sci., Univ. of Tsukuba, 3.Ph.D. Prog. in Hum. Bio., SIGMA, Univ. of Tsukuba, 4.Dept. of Kansei, Behav. and Brain Sci., Grad. Sch. of Comp. Hum. Sci., Univ. of Tsukuba, 5.Div. of Mol. Brain Sci., Res. Inst. of Traditional Asian Med., Kindai Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2LBA-068] Lin28a regulates seizure-induced aberrant hippocampal neurogenesis and epilepsy-associated cognitive impairments

〇Cheong A Bae¹, Jung-Ho Cha², Seong Yun Kim¹, Jenny Hsieh³, Kyung-Ok Cho¹ (1.Department of Pharmacology, College of Medicine, The Catholic University, Seoul, Korea, 2.Department of Anatomy, College of Medicine, The Catholic University, Seoul, Korea, 3.Department of Biology, The University of Texas at San Antonio, Texas, USA)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2LBA-069] Peripheral blood CD8⁺ T cell subsets correlated with PD-1 Ab response in melanoma patients by scRNA-seq analysis

〇Shigeki Ohta¹, Daichi Matsumoto¹, Haruna Nagumo¹, Tomonobu Fujita¹, Satoru Takahashi², Kenjiro Namikawa², Shigehisa Kitano³, Naoya Yamazaki², Yutaka Kawakami¹ (1.Cell. Signal., Inst. Adv. Med. Res., Keio Univ., Sch. Med., 2.Dept. of Dermatologic Oncology, Natl. Cancer Hospital, 3.Dept. of Exp. Therap., Natl. Cancer Hospital)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2LBA-070] Meta-analysis in exhausted T cells from Homo sapiens and Mus musculus provides novel targets for immunotherapy

〇LIN ZHANG¹, Yicheng Guo², Hafumi Nishi¹ (1.Tohoku University, Graduate School of Information Sciences, 2.Columbia University, Department of Systems Biology)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2LBA-071] Development of in vivo delivery system of CRISPR/Cas9 targeting hepatitis B virus

MEH Kayesh¹, Yutaka Amako², 〇Kyoko Kohara¹, Md Abul Hashem¹, Michinori Kohara² (1.Kagoshima University, 2.The Tokyo Metropolitan Institute of Medical Science)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2LBA-072] Sesamin suppresses ageing phenotypes in adult intestinal, muscular and nervous systems through the activation of Nrf2/CnC-dependent transcription in Drosophila

〇Dat T. Le¹, Yasuyuki Nakaraha¹, Makiko Ueda¹, Kazuko Okumura¹, Jun Hirai¹, Yosuke Sato², Daisuke Takemoto², Namino Tomimori², Yoshiko Ono², Masaaki Nakai², Hiroshi Shibata², Yoshihiro H. Inoue¹ (1.Dept. of Insect BioMed., Kyoto Inst. Tech., 2.Suntory Wellness Ltd.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2LBA-073] Mutant IDH1 triggers Oncogene-Induced Senescence via upregulation of p16INK4a

〇Takeshi Kamakura^1,2, Yonghui Jin^1,2, Sakura Tamaki^1,2, Makoto Watanabe³, Takeshi Okamoto⁴, Hiroyuki Yoshitomi^5,6, Junya Toguchida^1,2,6,7 (1.Dept. of Tissue Regeneration, IFLMS, Kyoto Univ., 2.Dept. of Growth and Differentiation, CiRA, Kyoto Univ., 3.Life Sci. Res. Center, Shimadzu Corp., 4.Japanese Red Cross Otsu Hospital, 5.Dept. of Immunity and Cell Biology, Grad. Sch. of Med., Kyoto Univ., 6.Dept. of Orthopaedic Surgery, Grad. Sch. of Med., Kyoto Univ., 7.Inst. for Adv. of a Clin. and Transl. Sci., Kyoto Univ. Hospital, Kyoto Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2LBA-074] Nutrient Deprivation Inhibits p53 Activation by Nucleolar Stress

〇Pan mh Melvin¹, Tsuyoshi Osawa¹ (1.Dept. of Nutriomics one., RCAST, Univ. of Tokyo)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2LBA-075] DNA methylation of open chromatin in colorectal cancer

〇NURUL SYAKIMA AB MUTALIB¹, Muhiddin Ishak¹, Rashidah Baharudin¹, Isa Mohamed Rose², Luqman Mazlan³, Zairul Azwan Mohd Azman³, Nor Shahidah Mahamad Nadzir¹, Nadiah Abu¹, Rahman Jamal¹ (1.UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia , 2.Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia, 3.Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[2LBA-076] Anti-C3b antibody decrease expression of CD59 and help MAC attack on cancer cell.

〇Hinako Takano¹, Yoshihito Suda² (1.Dept. of Food, Agri and Env. Sci., Grad. Sch. of Food, Agri and Env. Sci., Univ. of Miyagi, 2.Dept. of Food, Agri and Env. Sci., Grad. Sch. of Food, Agri and Env. Sci., Univ. of Miyagi)

The 42nd Annual Meeting of the Molecular Biology Society of Japan