[4P-0095] Roles of Cdc7 and its activation subunit ASK(Dbf4) in immune cell proliferation and differentiation

〇Tomohiro Iguchi¹, Satoshi Yamazaki¹, Tomio Ono², Rie Ishii², Karin Hori^1,3, Shunsuke Kobayashi^1,3, Hisao Masai^1,3 (1.Dept. of Genome Med., Tokyo Metro. Inst. Med. Sci., 2.Cent. for Basic Tech. Res., Tokyo Metro. Inst. Med. Sci., 3.Dept. Comp. Biol. and Med. Sci., Univ. of Tokyo)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0096] Roles of Dbf4/ASK, the activation subunit of Cdc7, in brain development

〇Shunsuke Kobayashi^1,2, Tomohiro Iguchi¹, Karin Hori^1,2, Rie Ishii³, Tomio Ono³, Chiaki Maruyama⁴, Satoshi Yamazaki¹, Hisao Masai¹ (1.Genome Dynamics Project, Tokyo Metropolitan Institute of Medical Science, 2.Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 3.Laboratory for Transgenic Technology, Tokyo Metropolitan Institute of Medical Science, 4.Neural Network Project, Tokyo Metropolitan Institute of Medical Science)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0097] Germline mutations observed in Mth1/Mutyh double knockout mice

〇Kunihiko Sakumi¹, Mizuki Ohno², Noriko Takano^2,3, Yusaku Nakabeppu¹ (1.Div. Neurofunctional Genomics, Med. Inst. Bioreg., Kyushu Univ., 2.Dept. Med. Biophys. & Radiat. Biol., Med. Sci., Kyushu Univ., 3.Faculty of Design, Kyushu Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0098] PARP inhibition and microRNA upregulation as a new combination therapy for brain tumors

〇Michiyo Okui¹, Hellen R. Russell², Peter J. McKinnon² (1.Toin University of Yokohama, 2.St. Jude Children's Research Hospital,)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[3LBA-111(2AW-07-2)] PARP inhibitor improves cardiac function in mice with heart failure

〇Manami Katoh¹, Seitaro Nomura², Toshiyuki Ko², Kanna Fujita², Shintaro Yamada², Tatsuro Sasa², Masamichi Ito², Hiroyuki Aburatani¹, Issei Komuro² (1.Genome. Sci. Lab.,RCAST.,Univ. of Tokyo, 2.Dept. of Cardiol.,Univ. of Tokyo)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0100] HDAC3 induces translocation of XPC from active gene promoters to DNA lesions after UV irradiation to promote nucleotide excision repair

〇Hiroyuki Niida¹, Koji Nishimoto¹, Akira Motegi², Masatoshi Kitagawa¹ (1.Dept of Mol. Biol., Hamamatsu Univ. Sch. of Med., 2.Dept of Radiation Genetics, Kyoto Univ. Grad. Sch. of Med.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0101] Alterations in the RNA polymerase IIo ubiquitination cause TC-NER defect and Cockayne syndrome-like premature aging phenotype in mice

〇Yuka Nakazawa¹, Yuichiro Hara¹, Yasuyoshi Oka¹, Okiru Komine², Diana van den Heuvel³, Chaowan Guo¹, Yasukazu Daigaku⁴, Mayu Isono¹, Yuxi He¹, Mayuko Shimada¹, Kana Katoh¹, Nan Jia¹, Satoru Hashimoto¹, Yuko Kotani⁵, Yuka Miyoshi², Miyako Tanaka⁶, Akira Sobue², Norisato Mitsutake⁷, Takayoshi Suganami⁶, Akio Masuda⁸, Kinji Ohno⁸, Shinichiro Nakada⁹, Tomoji Mashimo⁵, Koji Yamanaka², Martijn S. Luijsterburg³, Tomoo Ogi¹ (1.Dept. of Genet., RIeM, Nagoya Univ., 2.Dept. of Neurosci. & Pathobiol., RIeM, Nagoya Univ., 3.Dept. of Hum. Genet., LUMC, 4.Frontier Res. Instit. for Interdiscip. Sci., Tohoku Univ., 5.Inst. of Experi. Animal Sci., Grad. Sch. of Med., Osaka Univ., 6.Dept. of Mol. Med. and Metab., .RIeM, Nagoya Univ., 7.Dept. of Rad. Med. Sci., Atom. Bomb Dis. Inst., Nagasaki Univ., 8.Div. of Neurogenet., Cent. for Neuro. Dis. & Canc., Nagoya Univ. Grad. Sch. of Med., 9.Dept. of Bioreg. & Cellul. Resp., Grad. Sch. of Med., Osaka Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0102] Monitoring DNA lesions and progress of nucleotide excision repair by ChIP-seq data

〇Yuichiro Hara¹, Yuka Nakazawa¹, Yasuyoshi Oka¹, Okiru Komine², Diana van den Heuvel³, Chaowan Guo¹, Yasukazu Daigaku⁴, Mayu Isono¹, Yuxi He¹, Mayuko Shimada¹, Kana Katoh¹, Nan Jia¹, Satoru Hashimoto¹, Yuko Kotani⁵, Yuka Miyoshi², Miyako Tanaka⁶, Akira Sobue², Norisato Mitsutake⁷, Takayoshi Suganami⁶, Akio Masuda⁸, Kinji Ohno⁸, Shinichiro Nakada⁹, Tomoji Mashimo⁵, Koji Yamanaka², Martijn S. Luijsterburg³, Tomoo Ogi¹ (1.Dept. of Genet., RIeM, Nagoya Univ., 2.Dept. of Neurosci. & Pathobiol., RIeM, Nagoya Univ., 3.Dept. of Hum. Genet., LUMC, 4.Frontier Res. Instit. for Interdiscip. Sci., Tohoku Univ., 5.Inst. of Experi. Animal Sci., Grad. Sch. of Med., Osaka Univ., 6.Dept. of Mol. Med. and Metab., .RIeM, Nagoya Univ., 7.Dept. of Rad. Med. Sci., Atom. Bomb Dis. Inst., Nagasaki Univ., 8.Div. of Neurogenet., Cent. for Neuro. Dis. & Canc., Nagoya Univ. Grad. Sch. of Med., 9.Dept. of Bioreg. & Cellul. Resp., Grad. Sch. of Med., Osaka Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0103] Analysis of RNA-mediated regulation of NER

〇Mari T. Furukawa¹, Masayuki Kusakabe¹, Wataru Sakai¹, Masayuki Yokoi¹, Kaoru Sugasawa¹ (1.Biosignal Res. Ctr., Kobe Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0104] DNA damage detection in nucleosomes involves DNA register shifting

〇Syota Matsumoto^1,2, Simone Cavadini^1,2, Richard D. Bunker^1,2, Ralph S. Grand^1,2, Alessandro Potenza^1,2, Julius Rabl^1,2, Junpei Yamamoto³, Andreas D. Schenk^1,2, Dirk Schuebeler^1,2, Shigenori Iwai³, Kaoru Sugasawa⁴, Hitoshi Kurumizaka^5,6, Nicolas H. Thomae^1,2 (1.Friedrich Miescher Institute for Biomedical Research, 2.Univ. of Basel, 3.Division of Chemistry, Grad. Sch. of Eng. Sci., Osaka Univ., 4.Biosignal Res. Cent., and Grad. Sch. of Sci., Kobe Univ., 5.Lab. of Chromatin Structure and Function, Institute for Quant. Biosci., The Univ. of Tokyo, 6.Grad. Sch. of Advanced Sci. and Eng., Waseda Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan