[4P-0446] Identification of factors modulating the clearance of aggregate-prone tau by genome-wide CRISPR screening

〇Shinpei Ao¹, Yasuyuki Sakurai¹, Shoshiro Hirayama¹, Shigeo Murata¹ (1.Grad. Sch. of Pharm Sci, Univ. of Tokyo)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0447] Inhibition of latent pseudorabies virus reactivation with CRISPR-Cas9 system

〇Seiichi Tanaka¹ (1.CTR. Exp. Anim., Fukuoka Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0448] Gene therapy for DRPLA model mice by AAV-delivered CRISPR / Cas9.

〇Shoichiro Ando¹, Taisuke Kato², Yuka Koike¹, Sachiko Hirokawa², Kenta Kobayashi³, Shoji Tsuji⁴, Osamu Onodera^1,2 (1.Dept. of Neurology, BRI, Niigata Univ., 2.Dept. of Mol. Neuroscience, BRI, Niigata Univ., 3.Dept. of Viral Vector Development, NIPS, 4.Dept. of Molecular Neurology, Univ. of Tokyo)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0449(1AW-02-6)] The study in the oxygen-dependent and insulin-like growth factors involved in the multipotent stem cells derived from brain pericytes following ischemia

〇Rika Sakuma¹, Tomohiro Matsuyama², Takayuki Nakagomi^2,3, Susumu Imaoka¹ (1.Dept. of Biomed. Chem., Sch. of Sci. and Tech., Kwansei Gakuin Univ., 2.Dept. of therap. progress in brain diseases, Hyogo Col. of Med., 3.Inst. for Advanced Med. Sci., Hyogo Col. of Med.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0450] MeCP2-mediated miR-199a processing regulates fate specification of neural stem cells

〇Hideyuki Nakashima¹, Keita Tsujimura², Koichiro Irie¹, Takuya Imamura¹, Masataka Ishizu¹, Miao Pan¹, Hideyuki Nakashima¹ (1.Dept. of Stem. Cell. Biol. Med., Grad. Sch. of Med. Sci., Kyushu Uni, 2.Dept. of Psychi., Grad. Sch of Med., Nagoya Uni)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0451] iPSC-derived neurons lacking TSC2 show abnormal spontaneous activities in vitro

〇Chihiro Hisatsune¹, Tadayuki Shimada¹, Kanato Yamagata¹ (1.Tokyo Metropolitan Institute of Medical Science)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0452] Evaluation of the efficacy and safety of a new drug candidate for Niemann-Pick disease type C

〇Minami Soga¹, Yoichi Ishitsuka², Mikoto Hamasaki¹, Kaori Yoneda³, Hirokazu Furuya⁴, Muneaki Matsuo⁵, Hironobu Ihn⁶, Noemi Fusaki⁷, Kimitoshi Nakamura³, Naomi Nakagata⁸, Fumio Endo³, Tetsumi Irie², Takumi Era¹ (1.Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2.Department of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 3.Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University, 4.Department of Cardiology, Neurology and Aging Science, Kochi University Medical School, 5.Department of Pediatrics, Saga University, Faculty of Medicine, 6.Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 7.Keio University School of Medicine, 8.Division of Reproductive Engineering, Center for Animal Resources and Development, Kumamoto University)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0453] Molecular mechanism regulating induced expression of Ror2 in reactive astrocytes and its role in the injured brain

〇Yuki Tanaka¹, Mitsuharu Endo¹, Yasuhiro Minami¹ (1.Dept.of Med. Sci., Grad. Sch. of Med., Kobe Univ. )

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0454] Combinatorial therapy of epothilone B and HMGB1 antibody for spinal cord injury

〇Yicheng Zhu¹, Naohiro Uezono¹, Tatsuya Nagai¹, Kinichi Nakashima¹ (1.Dept. of Stem Cell Biol. and Med., Grad. of Sch. of Med. Sci., Univ. of Kyushu)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0455] Analysis of neuroprotective effects by plant-derived compounds

〇Nozomi Tagai^1,2, Ayako Tanaka^1,2, Akira Sato¹, Fumiaki Uchiumi², Sei-ichi Tanuma³ (1.Dept. Biochem., Fac. Pharm. Sci., Tokyo Univ. Sci., 2.Dept. Gene Regul., Fac. Pharm., Tokyo Univ. Sci., 3.Dept. Genomic Med., Res. Inst. Sci. Tech., Tokyo Univ. Sci.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan