[1P-0615] Application of human/mouse artificial chromosome technology (14) : Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism

〇Satoshi Abe^1,2, Kaoru Kobayashi³, Masumi Hirabayashi^4,5, Naoyo Kajitani¹, Kanako Kazuki¹, Jiro Kuze^1,6, Tetsushi Sakuma⁷, Takehito Kaneko^8,9, Tomoji Mashimo^9,10, Ryoichi Fujiwara¹¹, Yasuko Tsukazaki¹², Naoto Senda¹², Takashi Yamamoto⁷, Mitsuo Oshimura^1,2, Yasuhiro Kazuki^1,13 (1.CERC, Tottori Univ., 2.Trans Chromosomics Inc., 3.Grad. Sch. of Phrma. Sci., Chiba Univ., 4.Natl. Inst. for Pysiol. Sci., 5.Dept. of Physiol. Sci., Sch. of Life Sci., SOKENDAI, 6.Taiho Pharma. Co., Ltd., 7.Div. of Integr. Sci. for Life, Grad. Sch. of Integr. Sci. for Life, Hiroshima Univ., 8.Div. of Sci. & Eng., Grad. Sch. of Arts & Sci., Iwate Univ., 9.Inst. of Lab. Anim., Grad. Sch. of Med., Kyoto Univ., 10.Inst. of Exp. Anim. Sci., Grad. Sch. of Med., Osaka Univ., 11.Sch. of Pharm., Kitasato Univ., 12.Tsukuba Bioanal. Lab., Shin Nippon Biomed. Lab., Ltd., 13.Dept. of Biomed. Sci., Grad. Sch. of Med. Sci., Tottori Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[1P-0616] Transplacental delivery of CRISPR components via tail vein of pregnant female causes mutations in embryonic cardiomyocytes of murine fetuse

〇Shingo Nakamura¹, Naoko Ando¹, Satoshi Watanabe², Masayuki Ishihara¹, Masahiro Sato³ (1.Div.Biomed.Eng., Natl.Def.Med.Coll.Res.Inst., 2.Anim.Genome, Div.Anim.Breed.Res., NILGS, 3.Sect.Gene.Exp.Reg., Front.Sci.Res.Ctr., Kagoshima Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[1P-0617] Analysis of transgene insertion pattern in a transgenic mouse strain using a long-read DNA sequencer

〇Osamu Suzuki¹, Minako Koura¹, Kozue Uchio¹, Mitsuho Sasaki¹ (1.National Institutes of Biomedical Innovation, Health and Nutrition)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[1P-0618] Illustration of circadian rhythm development by an artificial transcription factor

〇ZHEN QI ¹, Miki Imanishi², Miho Tamai³, Yoh-ichi Tagawa¹ (1.Tokyo Institute of Technology, School of Life Science and Technology, 2.Kyoto University, Institute for Chemical Research, 3.Hokkaido University, Faculty of Dental Medicine)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[1P-0619(2PW-07-8)] Identification of molecular pathological mechanism in heart failure using single-cell RNA sequencing

〇Momoko Hamano¹, Seitaro Nomura^2,3, Hiroyuki Aburatani³, Issei Komuro², Yoshihiro Yamanishi¹ (1.Grad. Sch. of Bioinfo., KIT, 2.Grad. Sch. of Med., Univ. of Tokyo, 3.Res. Center of Sci., Univ. of Tokyo)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[1P-0620] Mechanism of pulmonary fibrosis by bronchiolar epithelial cell dysplasia using a novel interstitial pneumonia mouse model (induced-usual interstitial pneumonia model)

〇Satoshi Kanazawa¹, Yoko Miura¹ (1.Dept. of Mol. Cell Biol., Grad. Sch., Nagoya City Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[1P-0621] Fibroblasts in interstitial pneumonia mouse model (iUIP model) express elevated PDGFRα cause pulmonary fibrosis

〇Toshiko Takenaka¹, Yoko Miura¹, Satoshi Kanazawa¹ (1.Dept. of Mol. Cell Biol., Grad. Sch., Nagoya City Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[1P-0622] Development of drug delivery system for tissue fibrosis targeting Type III intermediate filament

〇Inu Song¹, Beomju Hwang¹, Izumi Hamano², Hirohiko Ise³ (1.Grad. Sch. of Eng., Kyushu Univ., 2.Fac. of Eng., Kyushu Univ., 3.IMCE, Kyushu Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[1P-0623] Development of a highly sensitive assay for autoantibody detection in neuromyelitis optica

〇Yukihiro Tanimura¹, Yoko Hiroaki², Yoshinori Fujiyoshi¹ (1.CeSPL, TMDU, 2.CeSPI, Nagoya Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[1P-0624] Study and development of innovative biomarker for acute hepatitis diagnosis

〇Yasuhiro Yonezuka¹, Hiromasa Imaishi^1,2 (1.Fac. Agric., Kobe Univ., 2.Biosig. Res. Ctr., Kobe Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan