[2P-857_1PS-04-04] Down-regulation of tumor suppressor sST2 in hypoxic colorectal cancer cells and suppression of tumor growth and metastasis by its restoration

^○Miho Akimoto¹, Takao Susa¹, Noriyuki Okudaira¹, Nobuko Kosikawa², Harumi Hisaki¹, Masayoshi Iizuka^1,3, Keizo Takenaga², Mimi TamamoriAdachi¹ (1.Dept. of Biochem., Teikyo Univ. Sch. of Med., 2.Lab. Innov. Cancer Ther., Chiba Cancer Ctr. Res. Inst., 3.Med. Educ. Ctr., Teikyo Univ. Sch. of Med.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-858_2SP-08-08] Bell-shaped dose response to tankyrase inhibitors in the drug-tolerant patient-derived colorectal cancer cells

^○Shun Morino^1,2, Tetsuo Mashima¹, Fumiyuki Shirai³, Satoshi Nagayama^4,5, Ryohei Katayama^6,2, Hiroyuki Seimiya^1,2 (1.Div. Mol. Biother., Cancer Chemother. Ctr., JFCR, 2.Grad. Sch. Front. Sci., Uni. Tokyo, 3.Unit. Drug Discov., CSRS., RIKEN, 4.Dep. Colorectal. Surg., Cancer Inst. Hosp., JFCR, 5.Dep. Surg., Uji-Tokushukai Med Ctr, 6.Div. Exp. Chemother., Cancer Chemother. Ctr., JFCR)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-859_2AS-15-05] Targeting vitamin metabolism as a potential strategy to treat pancreatic cancer

^○Masahiro Sonoshita (Div. Biomed. Oncol., Inst. for Genet. Med., Hokkaido Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-860_2SP-08-07] Development of trispecific antibodies targeting cancer cells, T cells, and T cell co-stimulatory molecules

^○Yuki Kato¹, Izumi Kumagai², Ryutaro Asano² (1.Dept. of Ind. Technol. and Innovation, Grad. Sch. of Eng., Tokyo Univ. of Agric. & Technol., 2.Dept. of Biotechnol. and Life Science, Grad. Sch. of Eng., Tokyo Univ. of Agric. & Technol.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-862] Signaling heterogeneity of cancer progression and invasion in human gastric cancer 3D-organoids infected by Helicobacter pylori

^○Kazushige Yokoyama, ChiaChen Ku, Kenly Wuputra, ChungJung Liu, DengChyang Wu (Graduate Institute of Medicine. Kaohsiung Med Univ. Taiwan)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-863] Challenges in the Practical Application of Mucin as a Drug Carrier in the Treatment of Peritoneal Dissemination

^○Nonoka Misawa, Rei Kawashima, Shun Tamaki, Tatsunori Maekawa, Takafumi Ichikawa (Dept. of Regulation Biochem., Grad. Sch. of Med. Sci., Univ. of Kitasato)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-864] Optimization of Cell Microarray Chip Design for Single-Cell Trapping and Culture

^○Hidetaka Ueno^1,2, Hajime Shigeto³, Akira Iizuka⁴, Yasuto Akiyama⁴, Shohei Yamamura³ (1.CAMED, Kobe Univ, 2.Dept. of Med. Eng., Grad Sch. of Med., Kobe Univ, 3.Health and Medical Research Institute, AIST, 4.Shizuoka Cancer Center)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-865_1PS-04-01] Single-cell transcriptomics for evaluating early clonal expansion in breast cancer

^○Jun Nakayama^1,2, Yusuke Yamamoto¹ (1.Lab. of Integr. Oncol., Natl. Cancer Ctr. Res. Inst., 2.Dept. of Oncogenesis Growth Regulation, Res. Inst., Osaka Intl. Cancer Inst.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-866] Cysteine targeted inhibition of RET kinase activity

^○Ryogen Hosoda^1,2,3, Yoshiyuki Kawamoto^1,2,3, Kozue Takeda^1,2,3 (1.Chubu Univ., 2.Grad. Sch. of Life and Health Sciences, 3.Dept. of Biomedical Sciences)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-867] IRL-1: A potential new target for cancer immunotherapy

^○JUN SIK LEE^1,2, MI EUN KIM¹, YE EUN LIM² (1.Dept. of Life. Sci., Sch. of Nat. Sci., Univ. of Chosun, 2.Dept. of Integr. Biol. Sci., Grad. Sch. of Nat. Sci., Univ. of Chosun)

The 46th Annual Meeting of the Molecular Biology Society of Japan