[1T08m-03] Identification of a novel ligand-binding cavity realizing the inhibition of cell adhesion mediated by P-cadherin, a protein forming homophilic dimerization

^○Akinobu Senoo¹, Satoru Nagatoishi², Kouhei Yoshida³, Sho Ito⁴, Go Ueno⁴, Takumi Tashima¹, Shota Kudo¹, Kouhei Tsumoto^1,2,3 (1.Dept. of Chem. Biotech., Sch. of Eng., Univ. of Tokyo, 2.Inst. of Med. Sci., Univ. of Tokyo, 3.Dept. of Bioeng., Sch. of Eng., Univ. of Tokyo, 4.RIKEN, SPring-8 Center)

The 92nd Annual Meeting of JBS |Wed. Sep 18, 2019 11:30 AM - 11:40 AM

[1T08m-04] The structures and biological activities of PPM1A activators isolated from Kuji amber

^○Yuka Miura¹, Aoi Noro², Hiroyuki Koshino³, Takao Kataoka⁴, Motoko Onishi⁵, Ken-ichi Kimura^1,2 (1.Grad. Sch. Arts. Sci., Iwate Univ., 2.Biol. Chem. Food. Sci., Iwate Univ., 3.RIKEN CSRS, 4.Appl. Biol., Kyoto Inst. Tech., 5.Biol. Chem., Chubu Univ.)

The 92nd Annual Meeting of JBS |Wed. Sep 18, 2019 11:40 AM - 11:50 AM

[1T08m-05] Development of drug delivery system for poorly water-soluble anti-cancer drug paclitaxel using intravital transporter protein with tumor-targeting peptide

^○Kosuke Furuta¹, Masatoshi Nakatsuji^1,2, Haruna Yoshida¹, Sayumi Tashiro¹, Takashi Inui¹ (1.Grad. Sch. of Life & Envi. Sci., Osaka Pref. Univ., 2.JSPS Research Fellow)

The 92nd Annual Meeting of JBS |Wed. Sep 18, 2019 11:50 AM - 12:00 PM

[1T09m-01] Inflammation and galectin-1 in the kidney of diabetic model mice

^○Shoya Kikuchi¹, Yuto Yoshida¹, Koyo Koda¹, Kazunori Sango², Toshiharu Yamamoto³, Yumi Terashima¹, Kazuharu Sugawara¹, Toshihiko Kadoya¹ (1.Biotechnology, Graduate School of Engineering, Maebashi Institute of Technology, 2.Diabetic Neuropathy Project, Department of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, 3.Brain Functions and Neuroscience Division, Department of Oral Science, Graduate School of Dentistry, Kanagawa Dental University)

The 92nd Annual Meeting of JBS |Wed. Sep 18, 2019 11:10 AM - 11:20 AM

[1T09m-02] Development of a novel therapeutic strategy for mitochondrial disease by modulation of respiratory chain activity

^○Takemasa Nagao¹, Yasunori Shintani¹, Yuya Nishida¹, Takaharu Hayashi², Seiji Takashima¹ (1.Dept. Med. Bio., Grad. Sch. Frontier BioSci., Osaka Univ., 2.Dept. Cardiovascular Med., Grad. Sch. Med., Osaka Univ.)

The 92nd Annual Meeting of JBS |Wed. Sep 18, 2019 11:20 AM - 11:30 AM

[1T09m-03] Hepatic macrophage iron content and phenotype in NASH

^○Yohei Kanamori¹, Miyako Tanaka¹, Michiko Itoh^2,3, Kozue Ochi¹, Akiko Watanabe¹, Takayoshi Suganami¹ (1.Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, 2.Department of Bioelectronics, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 3.Kanagawa Institute of Industrial Science and Technology)

The 92nd Annual Meeting of JBS |Wed. Sep 18, 2019 11:30 AM - 11:40 AM

[1T09m-04] Skeletal muscle cell oxidative stress as a possible therapeutic target for sarcopenia

^○Hideyuki Kinoshita, Sumihisa Orita, Kazuhide Inage, Seiji Ohtori (Department of Orthopedic Surgery, Chiba University Graduate School of Medicine)

The 92nd Annual Meeting of JBS |Wed. Sep 18, 2019 11:40 AM - 11:50 AM

[1T09m-05] Insulinotropic activity of sialidase inhibitor with a glucose-dependent manner

^○Yuka Fujita¹, Akira Minami¹, Yukiko Kaneko¹, Toshiaki Sawatani¹, Tadamune Otsubo², Kiyoshi Ikeda², Yuki Kurebayashi¹, Tadanobu Takahashi¹, Taeko Miyagi³, Tomohisa Ishikawa¹, Takashi Suzuki¹ (1.Sch. of Pharmaceu. Sci., Univ, of Shizuoka, 2.Sch. of Pharmaceu. Sci., Hiroshima Int Univ., 3.Miyagi Cancer Center Research Institute, Natori, Japan)

The 92nd Annual Meeting of JBS |Wed. Sep 18, 2019 11:50 AM - 12:00 PM

[1T09m-06(2P-388)] MITOL dysfunction in pituitary anterior lobe causes dwarfism by impaired STAT3/GH signaling pathway

^○Keigo Matsuno, Syun Nagashima, Issin Shiiba, Takeshi Tokuyama, Ryoko Inatome, Shigeru Yanagi (Tokyo university of pharmacy and life science)

The 92nd Annual Meeting of JBS |Wed. Sep 18, 2019 12:00 PM - 12:10 PM

[1T10m-01] Control of physical properties of ErbB3 by N-glycans

^○Motoko Takahashi¹, Koji Kato², Naoki Fujitani¹, Atsushi Saito¹, Yoshinao Wada³, Min Yao² (1.Department of Biochemistry, Sapporo Medical University School of Medicine, 2.Laboratory of X-ray structural biology, Faculty of Advanced Life science, Hokkaido University, 3.Department of Molecular Medicine, Research Institute of Osaka Womens and Childrens Hospital)

The 92nd Annual Meeting of JBS |Wed. Sep 18, 2019 11:10 AM - 11:20 AM