[1P-352] Post-translational modification of erythrocytes α-synuclein as a potential biomarkers in neurodegenerative disease.

^○Ryosuke Amagai¹, Natsumi Koike¹, Wataru Murata¹, Tsukasa Hara¹, Takayuki Kawai², Fuyuki Tateno³, Hitoshi Nukada⁴, Ryuji Sakakibara³, Ayako Okado-Matumoto¹ (1.Department of Biology, Faculty of Science, Toho University, 2.Department of Experimental-Research Medicine, Sakura Medical Center, Toho University, 3.Division of Neurology, Department of Internal Medicine, Sakura Medical Center, Toho University, 4.Department of Exploratory Medicine on Nature, Life and Man, Faculty of Medicine, Toho University)

The 92nd Annual Meeting of JBS

[1P-353] Suppression of extracellular release of Amyloid β by a novel type of C99 binding peptide.

^○Waka Sato¹, Miho Takahashi¹, Satoru Funamoto², Kiyotaka Nishikawa¹ (1.Doshisha University,Grad.School of Life and Medical Sciences, Molecular Life Sciences, 2.Doshisha University,Grad.School of Life and Medical Sciences, Neuropathology)

The 92nd Annual Meeting of JBS

[1P-354] Generation of iPS cells-derived mature neurons from familial Parkinson's disease patient by microRNA

^○Akito Hattori¹, Etsuro Ohta^2,3,4,5, Makiko Nagai⁶, Hiroyuki Miyosi⁵, Takefumi Sone⁵, Ryuto Nitta², Yoo S Andrew⁷, Kazuya Iwabuchi¹, Hideyuki Okano⁵ (1.Program in cellular Immunol, Gradu Sch Med Sci, 2.Div Clinical Immunol, Gradu Sch Med Sci, 3.Dept Immunol, Kitasato Univ of Allied Health Sci, 4.Dept Physiol, Keio Univ Sch Med, Tokyo,Japan R&D center for Cell Design,Institute for Regenerative Medicine and Cell Design, Kitasato Univ, 5.Dept Physiol, Keio Univ Sch Med, 6.Dept Neurol, Kitasato Univ Sch of Med, 7.Dept Developmental Biol, Washington Univ Sch of Med, St. Louis)

The 92nd Annual Meeting of JBS

[1P-355] Analysis of gain of toxicity induced by amyotrophic lateral sclerosis-linked SOD1 mutants

^○Riko Tabuchi, Takao Fujisawa, Hidenori Ichijo (Cell Signaling, Graduated of Pharmaceutical Sciences, University of Tokyo)

The 92nd Annual Meeting of JBS

[1P-356] Gene expression profiles of in vitro peri-implantitis model

Yoko Yamaguchi¹, Akira Aoki², Shinta Suzuki³, Takanori Iwata², ^○Mitsuhiro Ohshima⁴ (1.Department of Biochemistry, Nihon University School of Dentistry, 2.Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 3.Lifetime Oral Health Care Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 4.Department of Biochemistry, Ohu University School of Pharmaceutical Sciences)

The 92nd Annual Meeting of JBS

[1P-357] Single Enzyme Activity-based Protein Profiling - A Methodology for Ultra-sensitive Detection of Disease-related Alterations of Enzymatic Activities

^○Shingo Sakamoto¹, Toru Komatsu¹, Rikiya Watanabe², Yoku Cho³, Taiki Inoue¹, Mitsuyasu Kawaguchi⁴, Hidehiko Nakagawa⁴, Takaaki Ueno⁵, Takuji Okusaka⁶, Kazufumi Honda⁷, Hiroyuki Noji^3,8, Yasuteru Urano^1,9,10 (1.Grad. Sch. Pharm. Sci., The Univ. Tokyo, 2.RIKEN, 3.Grad. Sch. Eng., The Univ. Tokyo, 4.Grad. Sch. Pharm. Sci., Nagoya City Univ., 5.Osaka Dent. Univ., 6.Natl. Cancer Ctr. Hosp., 7.Natl. Cancer Ctr. Res. Inst., 8.ImPACT, 9.Grad. Sch. Med., The Univ. Tokyo, 10.AMED-CREST)

The 92nd Annual Meeting of JBS

[1P-358] Evaluation of hydrophobic anion on activation of epidermal growth factor receptor

^○Ayaka Sugiyama¹, Takeshi Sato², Masaya Hagiwara^3,4, Ikuo Fuji¹, Shiroh Futaki⁵, Ikuhiko Nakase^1,4 (1.Graduate School of Science, Osaka Prefecture University, 2.Kyoto Pharmaceutical University, 3.RIKEN, 4.NanoSquare Research Institute, 5.Institute for Chemical Research, Kyoto University)

The 92nd Annual Meeting of JBS

[1P-359] Identification of a novel ligand-binding cavity realizing the inhibition of cell adhesion mediated by P-cadherin, a protein forming homophilic dimerization

^○Akinobu Senoo¹, Satoru Nagatoishi², Kouhei Yoshida³, Sho Ito⁴, Go Ueno⁴, Takumi Tashima¹, Shota Kudo¹, Kouhei Tsumoto^1,2,3 (1.Dept. of Chem. Biotech., Sch. of Eng., Univ. of Tokyo, 2.Inst. of Med. Sci., Univ. of Tokyo, 3.Dept. of Bioeng., Sch. of Eng., Univ. of Tokyo, 4.RIKEN, SPring-8 Center)

The 92nd Annual Meeting of JBS

[1P-360] The structures and biological activities of PPM1A activators isolated from Kuji amber

^○Yuka Miura¹, Aoi Noro², Hiroyuki Koshino³, Takao Kataoka⁴, Motoko Onishi⁵, Ken-ichi Kimura^1,2 (1.Grad. Sch. Arts. Sci., Iwate Univ., 2.Biol. Chem. Food. Sci., Iwate Univ., 3.RIKEN CSRS, 4.Appl. Biol., Kyoto Inst. Tech., 5.Biol. Chem., Chubu Univ.)

The 92nd Annual Meeting of JBS

[1P-361] Development and evaluation of new proteasome inhibitory peptides

Asumi Komaki, Yunhao Zhu, Yuki Takahashi, Eri Ochiai, Akie Sumiya, ^○Makoto Hasegawa (Graduate School of Bioscience, Nagahama Institute of Bio-Science and Technology)

The 92nd Annual Meeting of JBS