[1P-302] New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis

^○Shinichi Inoue¹, Shingo Takahara^1,2, Sachiko Miyagawa-Tomita^3,4, Katsuhisa Matsuura⁵, Yasumi Nakashima⁶, Tetsuya Niihori¹, Yoichi Matsubara^1,7, Yoshikatsu Saiki², Yoko Aoki¹ (1.Department of Medical Genetics, Tohoku University Graduate School of Medicine, 2.Division of Cardiovascular Surgery, Graduate School of Medicine, Tohoku University, 3.Department of Animal Nursing Science, Yamazaki University of Animal Health Technology, 4.Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 5.Institute of Advanced Biomedical Engineering and Science, Tokyo Womens Medical University, 6.Department of Pediatrics, Seirei Hamamatsu General Hospital, 7.National Center for Child Health and Development)

The 92nd Annual Meeting of JBS

[1P-303] Molecular pathogenesis analysis of muscle of limb-girdle muscular dystrophy 2A model mouse

^○Fumiko Shinkai-Ouchi¹, Mayumi Shindo², Yoshiki Itoh¹, Naoko Doi¹, Shoji Hata¹, Yasuko Ono¹ (1.Calpain Project, Tokyo Metropolitan Institute of Medical Science, 2.The Center for Basic Technology Research, Tokyo Metropolitan Institute of Medical Science)

The 92nd Annual Meeting of JBS

[1P-304] GATA2 regulates lineage-specific immune cell differentiation

^○Atsushi Hasegawa^1,3, Yuta Takenaka¹, Yuna Hosaka¹, Masayuki Yamamoto^2,3, Ritsuko Shimizu^1,3 (1.Department of molecular hematology, Graduate school of medicine, Tohoku university, 2.Department of medical biochemistry, Graduate school of medicine, Tohoku university, 3.Tohoku Medical Megabank Organization, Tohoku university)

The 92nd Annual Meeting of JBS

[1P-305] Functional impacts of pathological mutations in IP3 receptor type I identified in spinocerebellar ataxia 29

^○Hideaki Ando^1,2, Matsumi Hirose^1,3, Katsuhiko Mikoshiba^1,4 (1.Laboratory for Developmental Neurobiology, Center for Brain Science, RIKEN, 2.Laboratory of Molecular Biomedicine for Pathogenesis, Faculty of Medicine, The University of Tokyo, 3.Collaborative Research Resources, School of Medicine, Keio University, 4.Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University)

The 92nd Annual Meeting of JBS

[1P-306] The DGCR2 gene encoding within 22q11.2 deletion syndrome region shows inducible expression and regulates TGF-beta signal activities during chondrocyte differentiation.

^○Kagemasa Kajiwara, Go Nagashima (Toque University, School of Medicine, Molecular Life Sciences)

The 92nd Annual Meeting of JBS

[1P-307] Expression reduction of crystallin proteins in the eye of a recessive mutant small-eye rat with lens involution and retinal detachment

^○Toshiyuki Yamada, Hatsune Hijikata, Ayane Suzuki, Naoki Saito, Hiroyuki Yamamoto (Dept. of Microbiol. and Mol. Cell Biol., Nihon Pharm. Univ.)

The 92nd Annual Meeting of JBS

[1P-308] Molecular mechanisms of p53-dependent neuronal cell death associated with tRNA metabolism

^○Masanori Inoue^1,2, Kazumasa Hada¹, Hiroshi Shiraishi¹, Tohru Ishitani³, Masaki Matsumoto⁴, Kenji Ihara², Toshikatsu Hanada¹ (1.Department of Cell Biology, Oita University Faculty of Medicine, 2.Department of Pediatrics, Oita University Faculty of Medicine, 3.Laboratory of Integrated Signaling Systems, Department of Molecular Medicine, Institute for Molecular & Cellular Regulation, Gunma University, 4.Department of Molecular and Cellular Biology and Division of Proteomics, Medical Institute of Bioregulation, Kyushu University)

The 92nd Annual Meeting of JBS

[1P-309] Accumulation of very long chain fatty acyl-CoA in ABCD1 deficient cells is enhanced by a lipid-lowering drug

^○Kotaro Hama¹, Yuko Fujiwara¹, Shigeo Takashima², Nobuyuki Shimozawa², Kazuaki Yokoyama¹ (1.Faculty of Pharma-Science, Teikyo University, 2.Division of Genomics Research Center, Gifu University.)

The 92nd Annual Meeting of JBS

[1P-310] Axonal transport of frizzled by kinesin-1 controls Wnt signaling at the nerve terminal

^○Mone Mitsuma¹, Yuzuha Shiraki¹, Haruka Saito¹, Ritsuko Takada², Toru Yamamoto^1,3, Shinji Takada², Saori Hata¹, Toshiharu Suzuki¹ (1.Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, 2.Okazaki Institute for Integrative Bioscience and National Institute for Basic Biology, National Institutes of Natural Sciences, 3.Department of Molecular Neurobiology, Faculty of Medicine, Kagawa University)

The 92nd Annual Meeting of JBS

[1P-311] Development of Hippocampal Dentate Gyrus before the Epilepsy Oset (Using APE Knockout Mice as a Model)

^○Yuji Kiyama^1,4,5, Hiroyuki Okuno^1,2, Makoto Naito³, Haruhiko Bito², Tatsuhiko Kodama⁴, Toshiya Manabe⁵, Motonobu Anai⁴ (1.4Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, 2.3Department of Neurochemistry, University of Tokyo Graduate School of Medicine, 3.Department of Pathology, Niigata Medical Center, 4.1Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 5.Division of Neuronal Network, Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo)

The 92nd Annual Meeting of JBS