[1P-0542] Age-related mitochondrial alterations in skeletal muscle depend on muscle fiber type units

^○Takuya Omura¹, Taichi Fukunaga¹, Shuuichi Mori¹, Mako Kono¹, Yoshihiro Noda², Yasunori Fujita³, Ikuroh Ohsawa³, Kazuhiro Shigemoto¹ (1.Dept. of Geriat. Med., Tokyo Metro. Inst. of Gerontol., 2.Dept. of Anim. Facil., Tokyo Metro. Inst. of Gerontol., 3.Dept. of Biol. Prcs. of Aging, Tokyo Metro. Inst. of Gerontol.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[1P-0543] Mutant IDH1 triggers Oncogene-Induced Senescence in normoxia

^○Takeshi Kamakura^{1, 2}, Yonghui Jin^{1, 2}, Sakura Tamaki^{1, 2}, Makoto Watanabe³, Takeshi Okamoto⁴, Hiroyuki Yoshitomi^{5, 6}, Junya Toguchida^{1, 2, 6, 7} (1.Dept. of Tissue Regen., inFront, Kyoto Univ., 2.Dept. of Cell Growth and Diff., CiRA, Kyoto Univ., 3.Life Sci. Res. Cent., Shimadzu Corp., 4.Japanese Red Cross Otsu Hosp., Siga, 5.Dept. of Immunol. and Cell Biol., Grad. Sch. of Med., Kyoto Univ., 6.Dept. of Orthop. Surg., Grad. Sch. of Med., Kyoto Univ., 7.iACT, Kyoto Univ. Hosp., Kyoto Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[1P-0544] Construction of a laminopathy therapeutic drug screening system using Saccharomyces cerevisiae.

^○keigo kikuchi, Akira Hosomi (Grad. sch. of Sci & Tech., Shinshu Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[1P-0545] Effect of aging on NAD repletion by nicotinic acid

^○Ayane Nishioka, Keisuke Yaku, Takashi Nakagawa (Dept. of Mol. and Med. Pharmacol., Faculty of Medicine, Univ. of Toyama)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[1P-0546] Untargeted blood metabolome identified frailty and sarcopenia markers

^○Masahiro Kameda¹, Takayuki Teruya², Mitsuhiro Yanagida², Hiroshi Kondoh¹ (1.Geriatric unit, Graduate School of Medicine, Kyoto University, 2.G0 Cell Unit, Okinawa Institute of Science and Technology Graduate University (OIST))

The 44th Annual Meeting of the Molecular Biology Society of Japan

[1P-0547] NRF3 contributes to tumorigenesis by activating mTORC1 through amino acid uptake

^○Shuuhei Hirose, Haruka Masuda, Tsuyoshi Waku, Akira Kobayashi (Grad. Sch. of Life and Med. Sci., Doshisha Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[1P-0548] Verification of the hypothesis of cancer immune evasion through amino acid competition by transcription factor NRF3

^○Haruka Masuda, Shuhei Hirose, Tsuyoshi Waku, Akira Kobayashi (Grad. Sch. of Life and Med. Sci., Doshisha Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[1P-0549] Functional disfunction of cell competition by multi-sequential carcinogenesis evokes diffuse invasion of transformed cells into basal membrane

^○Kazuki Nakai¹, Yukihiro Tasaki¹, Shinya Tanaka², Yasuyuki Fujita³, Shunsuke Kon¹ (1.Div. of Mol. Biol., Div. of Cancer Cell Biol., RIBS., TUS., 2.Div. of Mol. Oncology, IGM., Hokkaido Univ., 3.Dept. of Molecular Oncology, Grad. Sch. of Med., Kyoto Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[1P-0550] Runx dysregulates Myc under p53 deficiency via a TGFβ-responsive enhancer during osteosarcomagenesis

^○Tomoya Ueno, Yuki Date, Kosei Ito (Dept. of Mol Bone Biol., Grad.Sch. of Biomedi. Sci., Nagasaki Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[1P-0551] p57 expression identifies quiescent cancer stem cells resistant to 5-FU in neoplastic intestinal epithelia

^○Takeru Oka, Tsunaki Higa, Keiichi Nakayama (Dept. of Mol. Cell. Biol., Med. Inst. of Bioreg., Kyushu Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan