[3P-0507] Targeted macrocycles hamper hemagglutinin adsorption and fusion, and have antiviral effects in murine and macaque models of influenza

Makoto Saito¹, Yasushi Itoh², Fumihiko Yasui¹, Tsubasa Munakata¹, Daisuke Yamane¹, Makoto Ozawa³, Kenzaburo Yamaji¹, Naoki Yamamoto¹, Tomoko Honda¹, Takahiro Sanada¹, Kyoko TsukiyamaKohara³, Hiroaki Suga⁴, ^○Michinori Kohara¹ (1.Tokyo Metro. Inst. Med. Sci., 2.Shiga Univ. of Med. Sci., 3.Kagoshima Univ., 4.Univ. of Tokyo)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0508] Complete genome sequence analysis of binary enterotoxin BEC gene coding Clostridium perfringens strains

^○Kengo Ueda¹, Kazuki Kawahara¹, Narumi Kimoto¹, Yusuke Yamaguchi¹, Kazuhiro Yamada², Hiroya Oki³, Takuya Yoshida¹, Shigeaki Matsuda⁴, Yuki Matsumoto³, Daisuke Motooka³, Kentaro Kawatsu⁵, Tetsuya Iida⁴, Shota Nakamura³, Tadayasu Ohkubo¹, Shinya Yonogi^{4, 5} (1.Grad. Sch. of Pharm. Sci., Osaka Univ., 2.Dept. of Microbiol. and Med. Zoology, Aichi Pref. Inst. of Pub. Health., 3.Dept. of Inf. Metagen., Gen. Info. Res. Cent., RIMD, Osaka Univ., 4.Dept. of Bact. Inf., RIMD, Osaka Univ., 5.Divis. of Microbiol., Osaka Inst. of Pub. Health.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0509] The role of E protein on the formation of SARS-CoV-2 Virus-Like Particle

^○Koya Miura¹, Kotaro Ishida¹, Masashi Arakawa¹, Takeshi Tenno², Youichi Suzuki³, Takashi Nakano³, Hidekazu Hiroaki², Eiji Morita¹ (1.Dpt.of Biochem. and Mol. Biol., Faculty of Agri. and Life Sci., Hirosaki Univ., 2.Lab. of Struct. and Mol. Pharm., Grad. Sch. of Pharm. Sci., Nagoya Univ., 3.Dept. of Microbiol. and Infe. Con., Faculty of Med., Osaka Med. and Pharm. Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0510] Why and how are there so rare type 1 interferon-producing cells among virus-infected cells?

^○Yuki Masuda¹, Tomohiko Okazaki^{1, 2}, Shimpei Toyoda¹, Merve Bilgic¹, Yukiko Gotoh¹ (1.Dept. of Mol. Biol., Grad. Sch. of Pharm. Sci., Univ. of Tokyo, 2.Lab. of Mol. Cell. Biol, Institute for Genetic Medicine Hokkaido University)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0511] Efficient immunogenic peptide antigen delivery to dendritic cells using an ESCRT-mediated extracellular vesicle formation method

^○kouki maeda¹, saika kimura¹, Takashi Koyama², Ryuichi Nagashima², Koya Miura¹, Masashi Arakawa¹, Hirotaka Ebina^{3, 4}, Nobuyuki Tanaka², Eiji Morita¹ (1.Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Life Science, Hirosaki University, Japan, 2.Division of Cancer Biology and Therapeutics, Miyagi Cancer Center Research Institute, Natori, Japan, 3.Virus Vaccine Group, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan, 4.The Research Foundation for Microbial Diseases of Osaka University, Suita, Osaka, Japan)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0512] Development of NanoLuc-based indicator system to detect Coronavirus infections.

^○Masashi Arakawa^{1, 2}, Akiho Kashiwabara^{3, 4}, Hirotaka Ebina^{3, 4}, Eiji Morita^{1, 2} (1.Faculty of Agri. and Life Sci., Hirosaki Univ., 2.United Grad. Sch. of Agri. Sci., Iwate Univ., 3.Virus vaccine group, BIKEN Inno. Vacc. Res. Alli. Lab., Inst. for Open and Transdis. Rese. Init., Osaka Univ., 4.The Rese. Found. for Microbial Dise. of Osaka Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0513] Convergent use of phosphatidic acid for Hepatitis C virus and SARS-CoV-2 replication organelle formation

^○Keisuke Tabata¹, Vibhu Prasad¹, David Paul¹, JiYoung Lee¹, MinhTu Pham¹, Twu WoanIng¹, Christopher Neufeldt¹, Mirko Cortese¹, Berati Cerikan¹, Cong Si Tran¹, Christian Lüchtenborg², Philip V’kovski^{3, 4}, Katrin Hörmann⁵, André Müller⁵, Carolin Zitzmann⁶, Uta Haselmann¹, Jürgen Beneke⁷, Lars Kaderali⁶, Holger Erfle⁷, Volker Thiel^{3, 4}, Volker Lohmann¹, Giulio SupertiFurga^{5, 8}, Britta Brügger², Ralf Bartenschlager^{1, 9, 10} (1.Dept. of Infect. Dis., Heidelberg Univ., 2.BZH, Heidelberg Univ., 3.Inst. of Virol. Immunology, IVI, Bern, 4.Dept. of Infect. Dis. Pathobiology, Univ. of Bern, 5.CeMM, Vienna, 6.Inst. of Bioinfo. Univ. Med. Greifswald, 7.BioQuant, Heidelberg University, 8.Center for Physiology and Pharmacology, Med. Univ. of Vienna, 9.Div. Virus-Associated Carcinogenesis, German Cancer Research Center, 10.German Center for Infection Research, Heidelberg)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0514] Real-time monitoring of viral infection and replication in living cells

^○Masahiko Ito¹, Xiaoyu Li¹, Haruyo Aoyagi², Asako Murayama², Kwangsu Kim³, Toru Takada⁴, Shingo Iwami³, Koichi Watashi², Takanobu Kato², Hideki Aizaki², Tetsuro Suzuki¹ (1.Dept of Virol and Parasit, Hamamatsu Univ. Sch. of Med, 2.Dept. of Virol II, NIID, 3.iBLab, Div. of Biol. Sci., Nagoya Univ., 4.Dept. of Biol., Facul. of Sci., Kyushu Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0515] Isolation and Characterization of an Orthoreovirus from Indonesian Fruit Bats

^○Kittiya Intaruck¹, Agus Setiyono², Ekowati Handharyani², Yasuko Orba¹, Hirofumi Sawa¹, Michihito Sasaki¹ (1.Div. of Mol. Pathobiol., Int. Inst. Zoonosis Cont., Hokkaido Univ., 2.Dept. of Vet. Clin., Repro and Patho., Vet. Med., IPB Univ, Indonesia.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0516] Distinct types of stem cell divisions determine organ regeneration and aging in hair follicles

^○Hiroyuki Matsumura¹, Nan Liu¹, Daisuke Nanba¹, Ichinose Shizuko², Takada Aki¹, Sotaro Kurata³, Hironobu Morinaga¹, Yasuaki Mohri¹, Adele Arcangelis⁴, Shigeo Ohno⁵, Emi Nishimura^{1, 6} (1.Dept. of Stem Cell Biology, Med. Research Inst. Tokyo Med. and Dent. Univ., 2.Research Cent. for Med. and Dent. Sciences, Tokyo Med. and Dent. Univ., 3.Beppu Garden-Hill Clinic, Kurata Clinic., 4.Instite de Genetique et de Biologie Moleculaire et Cellulaire(IGBMC) , Dept. of Develop. and Stem Cells,, 5.Dept. of Mol. Biol., Yokohama City Univ. School of Med., 6.Div. of Aging and Regenerative Biol., Inst. of Med. Science, Univ. of Tokyo)

The 44th Annual Meeting of the Molecular Biology Society of Japan