[3P-0567] Impaired osteoblastic differentiation of MSCs suppresses normal hematopoiesis in MDS

^○Yasutaka Hayashi^{1, 2}, Kimihito Kawabata^{2, 3}, Yosuke Tanaka², Yasufumi Uehara⁴, Yo Mabuchi⁵, Koichi Murakami⁶, Shigeru Kiryu⁷, Yasunori Ota⁸, Yusuke Yoshioka⁹, Akira Nishiyama⁶, Yuya Kunisaki¹⁰, Tomofusa Fukuyama², Susumu Goyama², Fumio Arai¹⁰, Takahiro Ochiya⁹, Tomohiko Tamura⁶, Daichi Inoue¹, Toshio Kitamura² (1.Dept. of Hematology-Oncology, IBRI, FBRI, 2.Cellular Therapy, IMSUT, Univ. of Tokyo, 3.Hematology-Medical Oncology, Weill Cornell Medicine, 4.Dept. of Medicine and Biosystemic Science, Kyushu Univ., 5.Department of Biochemistry and Biophysics, Tokyo Medical and Dental University, 6.Dept. of Immunol., Grad. Sch. of Med., Yokohama City Univ., 7.Dept. of Radiology, Intl. Univ. of Health and Welfare Sch. of Med., 8.Dept. of Pathology, Research Hospital, The Institute of Medical Science, The University of Tokyo, 9.Dept. Mol. Cell. Med., Inst. Med. Sci, Tokyo Med. Univ., 10.Dept. of Cancer Stem Cell Research, Kyushu Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0568] Investigation of the involvement of mammary gland tissue-resident cells in the angiogenesis and local recurrence of triple-negative breast cancer

^○Miyu Shinke¹, Ryuichiro Hirano¹, Tetsuya Kadonosono¹, Hitomi Watanabe², Gen Kondoh², Shinae Kondoh¹ (1.School of Life Science and Technology, Tokyo Institute of Technology, 2.Institute for Frontier Life and Medical Sciences, Kyoto University)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0569] Distinct antitumor effects of iberdomide against Adult T-Cell Lymphoma/Leukemia (ATL) cells.

^○Hidekatsu Iha^{1, 2}, Yu Wang¹, Emi Ikebe^{1, 3}, Shunsuke Shimosaki⁴, Yoshiyuki Tsukamoto⁵, Mitsuo Hori⁶, Shotaro Hagiwara⁷, Shuichi Kusano⁸, Masumichi Saito³, Shuji Uno⁹, Kenichi Minehata⁹, Atsushi Suzuki⁹, Kazuhiro Morishita⁴ (1.Microbiol, Oita Univ Facult Med., 2.Mol Oncol, Oita Univ Facult Med., 3.Natl Inst Infect Dis., 4.Tumor Biochem, Univ Miyazaki Facult Med., 5.Mol Pathol, Oita Univ Facult Med., 6.Hematol, Ibaraki Cntr Hosp., 7.Mito Cntr, Tsukuba Univ Facult Med., 8.Onco Virus, Kagoshima Univ Facult Med., 9.Bristol-Myers Squibb Japan)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0570] The p53 target gene p53PAD5 confers stress resistance to intestinal epithelial cells

^○Tatsuki Yamamoto^{1, 2}, Kiyono Aoki¹, Hiroshi Takano³, Ayaka Yamamoto⁴, Shotaro Yamano¹, Masanobu Ohshima⁵, Ryoji Yao³, Toshio Watanabe⁴, Tomoaki Tanaka², Rieko Ohki¹ (1.Lab. of Fundamental Oncology, Natl. Cancer Ctr. Res. Inst., 2.Dept. Mol. Diag., Chiba Univ. Sch. Med., 3.Dept. Cell Biol., Cancer Inst.,JFCR, 4.Grad. Sch. of Humanities & Sci., Nara Women's Univ, 5.Div. Genet., Cancer Res. Inst., Kanazawa Univ)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0571] SREBP1a in macrophage regulates tumor growth.

^○Ken Takada, Hiroyuki Koike, Hinata Sato, Yumiko Oishi (Dept. Biochem. and Mol. Biol., Nippon Med. Sch.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0572] Identification and analysis of modifier loci post-K-ras mutation by QTL analysis using K-rasG12V mediated lung tumor mouse models.

^○Hiromitsu Saito, Noboru Suzuki (Dept. Animal Functional Genomics, Advanced Sci. Res. Center, Mie Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0573] APOBEC3G as a potential target for radiosensitization and construction of inhibitor screening system

^○Takae Onodera^{1, 2}, Ying Tong¹, Lichao Chen¹, Shoji Imamichi^{1, 2}, Mitsuko Masutani^{1, 2} (1.Dept. Molecular and Genomic Biomedicine & CBMM, Grad. Sch. Biomed. Sci., Nagasaki Univ., 2.Radioisotope Division, Natl. Cancer Ctr. Res. Inst.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0574] The effect of human prostate cancer cells via androgen receptor by novel platinum complex

^○Tasuku Arai¹, Masako Uemura², Seiji Komeda², Yoshihisa Hirota¹ (1.Grad. Sch. of Eng. and Sci., Shibaura Inst. of Tech., 2.Fac. of Pharm. Sci., Suzuka Univ. Med Sci.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0575] A mechanism of cell death resistance in response to a persisting autophagy inhibition in cancer cells

^○Manami Yabumoto, Riho Sato, Taichi Kurisu, Misuzu Nishida, Koji Kishimoto (Grad. Sch. of Tokushima Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0576] Exploring the Collaborative Metastasis Mediated by VHL Heterogeneity in Clear Cell Renal Cell Carcinoma

^○Moe Ishihara, Lily Wu, Junhui Hu (Dept. of Mol. and Med. Pharmacology)

The 44th Annual Meeting of the Molecular Biology Society of Japan