[3P-0467] Vascular Endothelial Cell Senescence Ameliorates Cognitive Impairment in APP/PS1 Mouse Model of Alzheimer’s Disease

^○Mao Mizoue¹, Sayo Horibe¹, Mio Kanda¹, Wakana Komabayashi¹, Tomomi Sakaguchi¹, Mei Narimatsu¹, Keiko Maeda¹, Shoji Kawauchi¹, Toru Tanaka¹, Naoto Sasaki¹, Koji Ikeda^{1, 2}, Noriaki Emoto¹, KenIchi Hirata³, Yoshiyuki Rikitake¹ (1.Kobe Pharma. Univ., 2.Grad. Sch. of Med. Sci., Kyoto Pref. Univ. of Med., 3.Kobe Univ. Grad. Sch. of Med.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0468] A regulatory mechanism of TREM2 through its 5' untranslated region

^○Motoaki Yanaizu, Haruka Adachi, Junichi Satoh, Yoshihiro Kino (Dept. of Bioinformatics and and Molecular Neuropathology, Grad. Sch., Univ. of Meiji Pharm.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0469] Outer membrane vesicles of Helicobacter pylori induce neuroinflammation: implication for Alzheimer´s disease

^○AhMee Park, Ikuo Tsunoda (Dept. of Microbiol., Fac. Med., Kindai Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0470] TSC inactivation increases neuronal network activity by enhancing Ca2+ influx via L-type Ca2+ channels

^○Chihiro Hisatsune¹, Tadayuki Shimada¹, Akitoshi Miyamoto^{2, 3}, Amy Lee³, Kanato Yamagata¹ (1.Synaptic Plasticity, TMiMS, 2.Lab. of Single-Mol. Cell Biol., Kyoto Univ., 3.Dept. of Neuroscience, University of Texas-Austin, Austin, USA)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0471] Development of intracerebral drug delivery technology using Claudin-5 binding molecules

^○Kousuke Muraoka¹, Keisuke Shirakura¹, Risa Funatsu¹, Saito Inoue¹, Takefumi Doi¹, Hiroyuki Takeda², Keisuke Tachibana¹, Masuo Kondoh¹, Yasushi Fujio¹, Yoshiaki Okada¹ (1.Grad. Sch. Pharm. Sci., Osaka University, 2.PROS, Ehime University)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0472] Loss of thioredoxin function confers cell death in neurons and oligodendrocytes

^○Iori Ohmori¹, Mamoru Ouchida², Hirohiko Imai³, Shinya Toyokuni⁴, Tomoji Mashimo⁵ (1.Edu., Grad. Sch. of Sci., Okayama Univ., 2.Med., Dent., and Pharm., Sci., Grad. Sch. of Sci., Okayama Univ., 3.Biomed., Engineer. Lab., Grad. Sch. of Info., Kyoto Univ., 4.Dept. of Pathol., Grad. Sch. of Med., Nagoya Univ., 5.Inst. of Exp. Anim. Sci., Grad. Sch. of Med., Univ. of Tokyo)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0473] Development of new mouse line for monitoring LINE-1 retrotransposition

^○Shinya Fujii¹, Yui Murata¹, Miki Bundo¹, Yutaka Nakachi¹, Kimi Araki², Kazuya Iwamoto¹ (1.Department of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, 2.Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0474] Highly expression of Lanosterol 14 alpha-demethylase (LDM, CYP51) in oligodendrocyte enhances remyelination following demyelination induced by cuprizone

^○Kentaro Nakashima, Kyoka Tsukuda, Raimu Kohara, Hikaru Fukui, Ryoma Kawada, SiYoung Song (Institute of Neuroscience, Tokushima Bunri Univ., Kagawa, Japan)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0475] Novel binding factors of SOD1 under zinc deficiency provide insights into the pathological mechanism of ALS

^○Shiyori Tanaka, Takao Fujisawa, Hidenori Ichijo (Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0476] Ninjinyoeito improves social behavior disorder in neuropeptide Y deficient zebrafish via HPA axis

^○Momoko Kawabe¹, Chihoko Horita², Takumi Nishida², Masaharu Komatsu², Kazuhiro Shiozaki², Akio Inui³ (1.Crs. Biol. Sci. Technol., Unit. Grad. Sch. Agricult. Sci., Kagoshima Univ., 2.Dep. Food Life Sci., Fac. Fish., Kagoshima Univ., 3.Dep. Pharmacol. Sci. Herb. Med., Grad. Sch. Med Dent. Sci., Kagoshima Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan