Academic Program [Oral A]

[D1441-1am] 17. Biofunctional Chemistry, Biotechnology

Wed. Mar 22, 2023 9:00 AM - 11:40 AM D1441 (1441, Bldg. 14 [4F])

Chair: Kazuya Matsuo, Takashi Sakamoto

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9:20 AM - 9:30 AM

[D1441-1am-01] Development of Theranostics Technology by Using Radiohalogens- Development of nucleophilic ¹⁸F fluorination using benzenesulfonyloxy groups with electron withdrawing substituent.

^○Shogo Iida¹, Tetsuto Tago², Jun Toyohara², Hiroshi Tanaka¹ (1. Tokyo Institute of Technology, 2. Tokyo Metropolitan Geriatric Medical Center)

[Lang.] Japanese

9:30 AM - 9:40 AM

[D1441-1am-02] Development of Theranostics Technology by Using Radiohalogens- Synthesis of ¹²⁵I-Labeled Activated Esters possessing a Neopentyl-Labeling Group

^○Masatoshi Tada¹, Yuta Kaizuka², Tomoya Uehara², Hiroshi Tanaka¹ (1. Tokyo Institute of Technology, 2. Chiba University)

[Lang.] Japanese

9:40 AM - 9:50 AM

[D1441-1am-03] Investigation for effects of the position of OH groups on the reaction mechanism of O₂^-・ and benzenetriols

Rumi Kobata¹, Kouki Tsuchiya¹, Ryota Nakano¹, ^○Yusuke Miyake¹, Kunihiko Tajima¹, Kenji Kanaori¹ (1. Kyoto Institute of Technology)

[Lang.] Japanese

9:50 AM - 10:00 AM

[D1441-1am-04] Control of mitotic cell division using the photoswitchable covalent inhibitor targeting CENP-E

^○Kazuya Matsuo¹, Shusuke Yamaoka¹, Tomonori Waku¹, Akio Kobori¹ (1. Kyoto Institute of Technology)

[Lang.] Japanese

Break （10:00 AM - 10:10 AM）

10:10 AM - 10:20 AM

[D1441-1am-05] Development of a method for simultaneous measurement of multiple factors in the intracellular local environment

^○Yuya Shibano¹, Zhang Zhengxiao¹, Eiji Nakata¹, Takashi Morii¹, Hisaaki Hirose², Shiro Hutaki² (1. Institute of advanced energy, Kyoto University, 2. Institute for Chemical Research, Kyoto University)

[Lang.] Japanese

10:20 AM - 10:30 AM

[D1441-1am-06] Development of Dual-responsive Photoluminescent Probe for Detection of Enzyme Activity and Reactive Oxygen Species

^○Kohei Takayama¹, Ayako Suzuki¹, Huo Wenting¹, Takashi Morimoto¹, Huiying Mu¹, Koji Miki¹, Ohe Koichi¹ (1. Kyoto university)

[Lang.] Japanese

10:30 AM - 10:40 AM

[D1441-1am-07] Development of cyanine dyes for identification of aldehyde dehydrogenase isoforms

^○Koki Miki¹, Daiki Yamanaka¹, Huiying Mu¹, Koji Miki¹, Kouichi Ohe¹ (1. Kyoto University)

[Lang.] Japanese

10:40 AM - 10:50 AM

[D1441-1am-08] Development of Water-soluble pH-Responsive Cyanine Dyes Containing Anionic Substituents

^○Shuai Shao¹, Huiying Mu¹, Koji Miki¹, Kouichi Ohe¹ (1. Kyoto University)

[Lang.] Japanese

Break （10:50 AM - 11:00 AM）

11:00 AM - 11:10 AM

[D1441-1am-09] Regulating the binding selectivity of dual-color fluorescence switch-on probe that responses with duplex and quadruplex DNA

Yuka Muraoka¹, Yu Yasuhara², Marina Iwai², ^○Takashi Sakamoto^1,2 (1. Grad. Sch. Systems Eng., Wakayama Univ., 2. Faculty of Systems Eng., Wakayama Univ.)

[Lang.] Japanese

11:10 AM - 11:20 AM

[D1441-1am-10] The promotion of expression of gene that causes triplet repeat disease using repeat-targeting DNA binding molecule

^○Junnosuke Hatanaka¹, Toshikazu Bando¹, Hiroshi Sugiyama² (1. Graduate school of Science, Kyoto University, 2. Institute for Integrated Cell-Material Sciences, Kyoto University)

[Lang.] Japanese

11:20 AM - 11:30 AM

[D1441-1am-11] Comparing the Properties of DNA-Binding Pyrrole−Imidazole Polyamides with Different Structures (Linear versus Cyclic)

^○Yuki Hirose¹, Huy N. Hoang², Kaori Hashiya¹, Toshikazu Bando¹, Hiroshi Sugiyama³, David P. Fairlie² (1. Graduate School of Science, Kyoto University, 2. Institute for Molecular Bioscience, The University of Queensland, 3. Institute for Integrated Cell-Material Science (WPI-iCeMS), Kyoto University)

[Lang.] English

11:30 AM - 11:40 AM

[D1441-1am-12] Synthesis and Evaluation of Pyrrole-Imidazole Polyamide Conjugates with Pyridostatin Analogs

^○Mitsuharu Ooga¹, Toshikazu Bando¹, Hiroshi Sugiyama² (1. Kyoto University Graduate School, 2. Institute for Integrated Cell-Material Sciencies, Kyoto University)

[Lang.] Japanese

Academic Program [Oral A]

[D1411-1am] 17. Biofunctional Chemistry, Biotechnology

Wed. Mar 22, 2023 9:00 AM - 11:40 AM D1411 (1411, Bldg. 14 [1F])

Chair: Satoshi Abe, Yoshitsugu Morita

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9:00 AM - 9:10 AM

[D1411-1am-01] Preparation of Artificial Metalloenzyme Chemically Modified with Pyridyl Group near the Active Site and Its Chemical Reactivity

^○Hiroki Kubo¹, Ryusei Matsumoto², Yoshitsugu Morita², Nobutaka Fujieda² (1. Osaka Prefecture University, 2. Osaka Metropolitan University)

[Lang.] Japanese

9:10 AM - 9:20 AM

[D1411-1am-02] Development of Artificial Metalloenzymes for Stereoselective Asymmetric Hydrogenation of an Aryl Ketone

^○Souto Kitazawa¹, Ryusei Matsumoto², Yoshitsugu Morita², Nobutaka Fujieda² (1. Osaka Prefecture University, 2. Osaka Metropolitan University)

[Lang.] Japanese

9:20 AM - 9:30 AM

[D1411-1am-03] Development of Artificial Metalloenzymes for Stereoselective Michael Addition Reaction

^○Tomohito Marumo¹, Ryusei Matsumoto¹, Saho Yoshioka², Yoshitsugu Morita¹, Nobutaka Fujieda¹ (1. Graduate School of Agriculture, Osaka Metropolitan Univ., 2. Graduate School of Life and Environmental sciences, Osaka Pref Univ.)

[Lang.] Japanese

9:30 AM - 9:40 AM

[D1411-1am-04] Preparation of Selenocysteine-containing Cupin Protein and Its Chemical Reactivity

^○Yuki Kinoshita¹, Hiroe Matsumoto², Sayaka Matsumoto¹, Yoshitsugu Morita², Nobutaka Fujieda² (1. Osaka Prefecture University, 2. Osaka Metropolitan University)

[Lang.] Japanese

9:40 AM - 9:50 AM

[D1411-1am-05] Formation of thioether-bridged cysteinyltyrosine by post-translational oxidation

^○Hiroe Matsumoto¹, Sayaka Matsumoto², Nobutaka Fujieda¹ (1. Osaka Metropolitan University, 2. Osaka Prefecture University)

[Lang.] Japanese

9:50 AM - 10:00 AM

[D1411-1am-06] Synthetic Studies of Artificial Serine Proteases (Ⅸ) : Comparison of Enzymatic Activities of Various Polymers with Free Functional Groups on the Histidine Residue

^○Shinzo Omiya¹, Takahiko Matsushita^1,2, Tetsuo Koyama¹, Ken Hatano^1,2, Koji Matsuoka^1,2 (1. Graduate School of Science & Engineering, Saitama University, 2. Advanced Institute of Innovative Technology (AIIT), Saitama University)

[Lang.] English

10:00 AM - 10:10 AM

[D1411-1am-07] Synthetic Studies of Photoimmunotherapeutic Agents (II): Synthesis of Bifunctional Silicon Phthalocyanines

^○Kanna Saito¹, Takahiko Matsushita^1,2,3, Tetsuo Koyama¹, Ken Hatano^1,2,3, Koji Matsuoka^1,2,3 (1. Grad. Sci.&Engin. Saitama University, 2. Adv. Inst. Innov. Tech. Saitama University, 3. Strategic Res. Ctr. Saitama University)

[Lang.] Japanese

Break （10:10 AM - 10:20 AM）

10:20 AM - 10:30 AM

[D1411-1am-08] Radical Coupling Reactions between Pyruvate and α-Bromoester Catalyzed by FAD/ThDP-Dependent Enzymes

^○Shuto Fujisawa¹, Shunsuke Kato¹, Takashi Hayashi¹ (1. Osaka University)

[Lang.] Japanese

10:30 AM - 10:40 AM

[D1411-1am-09] Improvement of Activity of Alcohol Dehydrogenase from Geotrichum candidum for Reduction of Bulky Ketones via Enzyme Engineering

^○Zhongyao Tang¹, Yuuki Takagi¹, Afifa Ayu Koesoema², Tomoko Matsuda¹ (1. Tokyo Institute of Technology, 2. Okayama University)

[Lang.] English

10:40 AM - 10:50 AM

[D1411-1am-10] Stabilization of an in-cell protein crystal by engineering the molecular interface.

^○Misaki Nagama¹, Satoshi Abe¹, Takafumi Ueno¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

10:50 AM - 11:00 AM

[D1411-1am-11] Ferritin cage engineering to isolate a defined number of Alpha- synuclein peptide fragments

^○Riwa Hao¹, Basudev Maity¹, Takafumi Ueno¹ (1. Tokyo Institute of Technology)

[Lang.] English

11:00 AM - 11:10 AM

[D1411-1am-12] Molecular design for immobilizing small molecules using cell-free protein crystallization

^○Xinchen Yao¹, Mariko Kojima¹, Satoshi Abe¹, Takafumi Ueno¹ (1. Tokyo Institute of Technology)

[Lang.] English

11:10 AM - 11:20 AM

[D1411-1am-13] Evaluation of co-crytallization behavior between proteins tagged with positively-charged peptide and DNA

^○Ayasa Nagatani¹, Kosuke Minamihata¹, Rie Wakabayashi¹, Masahiro Goto¹, Noriho Kamiya¹ (1. Kyushu university)

[Lang.] Japanese

11:20 AM - 11:30 AM

[D1411-1am-14] Construction of dipeptides libraries to explore hyperpolarized molecular probe candidates with specific activities for acute kidney injury model

^○Yuki Aketa¹, Yutaro Saito¹, Funinori Hyodo², Masayuki Matsuo², Shinsuke Sando¹ (1. The Univ. of Tokyo, 2. Gifu Univ.)

[Lang.] Japanese

Break （11:30 AM - 11:40 AM）

Academic Program [Oral A]

[D1411-1vn] 17. Biofunctional Chemistry, Biotechnology

Wed. Mar 22, 2023 4:10 PM - 6:30 PM D1411 (1411, Bldg. 14 [1F])

Chair: Chikashi Nakamura, Satoshi Yamaguchi

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4:10 PM - 4:20 PM

[D1411-1vn-01] Development of ¹⁹F MRI probe using phospholipid nanodiscs

^○Kodai Fukushima¹, Tomoya Yamamoto², Kazuya Kikuchi^2,3 (1. School of Engineering, Osaka University, 2. Graduate School of Engineering, Osaka University, 3. Immunology Frontier Research Center)

[Lang.] Japanese

4:20 PM - 4:30 PM

[D1411-1vn-02] Hetero triple helix formation of collagen model peptides and their application for tailor-made cell surface modification

^○Kazuki Yoshida¹, Michiya Matsusaki¹ (1. Grad. Sch. of Eng., Osaka Univ.)

[Lang.] Japanese

4:30 PM - 4:40 PM

[D1411-1vn-03] Development of cell designer molecules that provide drug-controlled release function in response to tumor weak acid environments

^○Kanta Iwamoto¹, Masahiko Nakamoto², Ryohei Katayama³, Michiya Matsusaki² (1. Osaka University, 2. Graduate School of Engineering, Osaka University, 3. cancer institute)

[Lang.] Japanese

4:40 PM - 4:50 PM

[D1411-1vn-04] Photoresponsive cell-trapping hydrogel layers for image-based single-cell sorting

^○Xueyang Li¹, Satoshi Yamaguchi¹, Akimitsu Okamoto¹ (1. The Univ. of Tokyo)

[Lang.] English

4:50 PM - 5:00 PM

[D1411-1vn-05] Reduction of side effects of photochemical internalization

^○Akinari Bando¹, Kazunori Watanabe¹, Takashi Ohtsuki¹ (1. Okayama univ.)

[Lang.] Japanese

5:00 PM - 5:10 PM

[D1411-1vn-06] Construction of a novel cancer cell-selective DDS molecular system incorporation of a matrix metalloprotease-9 substrate sequence and applying to an enhanced efficient cellular membrane uptake system

Ryota Azuma¹, Nagisa KANAZAWA¹, Masaki Mishijima¹, Yasuyuki Araki¹, Ikuhiko Nakase², ^○TAKEHIKO WADA¹ (1. Tohoku University, 2. Osaka Metropolitan University)

[Lang.] Japanese

5:10 PM - 5:20 PM

[D1411-1vn-07] Inhibition of cancer cell invasion by blocker of mechanosensitive chloride ion channels

^○Akane Nagata¹, Ayana Yamagishi^1,2, Chikashi Nakaura^1,2 (1. Grad. Sch. Eng., Tokyo Univ. Agric. Technol., 2. Cell. Mol. Biotech. Res. Inst., AIST)

[Lang.] Japanese

Break （5:20 PM - 5:30 PM）

5:30 PM - 5:40 PM

[D1411-1vn-08] Development of antimicrobial photodynamic therapy (aPDT) agents using fluoroporphyrin (TFPP) derivatives

^○Yukie Watanabe¹, Ayane Saeki¹, Nanase Matubayashi¹, Tsubasa Ito¹, Misaki Nishi¹, Shuntaro Machida¹, Kanako Negishi¹, Shiho Hirohara¹ (1. National Institute of Technology, Ube College)

[Lang.] Japanese

5:40 PM - 5:50 PM

[D1411-1vn-09] Functional analysis of common beta-sheet structure in the tail domain of intermediate filaments

^○Koki Uchida¹, Ayana Yamagishi^2,1, Akira Nagasaki³, Taro Ueda⁴, Chikashi Nakamura^2,1 (1. Tokyo Univercity of Agriculture and Technology, 2. Cell. Mol. Biotech. Res. Inst., AIST, 3. Biomed. Res. Inst., AIST, 4. Grad. Sch. Adv. Sci. Eng., Waseda Univ.)

[Lang.] Japanese

5:50 PM - 6:00 PM

[D1411-1vn-10] Synthesis of Red Blood Cell Conjugated with Polyoxazolines on the Surface

^○Mayuka Fujita¹, Wataru Okamoto¹, Ruka Yoshida¹, Teruyuki Komatsu¹ (1. Chuo University)

[Lang.] Japanese

6:00 PM - 6:10 PM

[D1411-1vn-11] Sialic acid-modified necleic acids that bind to various corona virus

^○Yuya Komorida¹, Yasuhito Ebara¹ (1. Kobe Univ.)

[Lang.] Japanese

6:10 PM - 6:20 PM

[D1411-1vn-12] Study on the development of pharmacological chaperones for Golgi endo-α-mannosidase

^○Shotaro Ikai¹, Taiki Kuribara¹, Kiichiro Totani¹ (1. Department of Science and Technology, Seikei University)

[Lang.] Japanese

6:20 PM - 6:30 PM

[D1411-1vn-13] Preparation of homogeneous antibody drugs having complex-type glycan containing bisecting GlcNAc.

^○Hasumi Muto¹, Yuto Nakamachi², Taiki Kuribara¹, Kiichiro Totani¹ (1. Department of Science and Technology, Seikei, 2. KH Neochem Co., Ltd.)

[Lang.] Japanese

Academic Program [Oral A]

[D1441-1vn] 17. Biofunctional Chemistry, Biotechnology

Wed. Mar 22, 2023 4:10 PM - 6:50 PM D1441 (1441, Bldg. 14 [4F])

Chair: Kunihiko Morihiro, Yusuke Takezawa

+Add all to schedule

4:10 PM - 4:20 PM

[D1441-1vn-01] Development of novel cyclized nucleic acids with the ability of
pseudorotaxane and catenane formation

^○Kazuki Kuwahara^1,2, Kazumitsu Onizuka^1,2, Sayaka Yajima^1,2, Yuuhei Yamano¹, Fumi Nagatsugi^1,2 (1. Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2. Graduate School of Science, Tohoku University)

[Lang.] Japanese

4:20 PM - 4:30 PM

[D1441-1vn-02] Photochemical Labeling of Nucleic Acid by Photo-Catalyst-Introduced DNA Probe

^○Yuuhei Yamano¹, Kazumitsu Onizuka^1,2, Madoka Sasaki², Shinichi Sato³, Fumi Nagatsugi^1,2 (1. IMRAM, Tohoku University, 2. Graduate School of Science, Tohoku University, 3. FRIS, Tohoku University)

[Lang.] Japanese

4:30 PM - 4:40 PM

[D1441-1vn-03] Cu^II-dependent control of a split-DNAzyme having consecutive ethenoadenine nucleobases as metal recognition sites

^○Silpa Chandran Rajasree¹, Yusuke Takezawa¹, Mitsuhiko Shionoya¹ (1. The University of Tokyo, Graduate School of Science)

[Lang.] English

4:40 PM - 4:50 PM

[D1441-1vn-04] Oligodeoxynucleotides bearing nitrobenzyl groups that functioned in hypoxic cells

^○Daigo Maehara¹, Tatuto Kikuchi¹, Tatsuya Nishihara¹, Kazuhito Tanabe¹ (1. Aoyama Gakuin University)

[Lang.] Japanese

4:50 PM - 5:00 PM

[D1441-1vn-05] Synthesis of 4'-C-aminoalkoxy-2'-deoxy-2'-fluoro analogs and characterization of those in gapmer-type of antisense molecules

^○Yuya Goto¹, Yoshihito Ueno¹ (1. Graduate School of Natural Science and Technology, Gifu University)

[Lang.] Japanese

5:00 PM - 5:10 PM

[D1441-1vn-06] Effect of aminoalkyl side chains modified at nucleoside sugar moieties on properties of RNAs with formacetal linkage

^○Hibiki Sawada¹, Yoshihito Ueno¹ (1. Graduate School of Natural Science and Technology, Gifu University)

[Lang.] Japanese

5:10 PM - 5:20 PM

[D1441-1vn-07] Design and synthesis of alkynylated C-pyridone nucleosides for selective unnatural base pairing

^○Wenjue Fan^1,2, Hidenori Okamura^1,2, Zhuoxin Dong^1,2, Giang Hoang Trinh^1,2, Fumi Nagatsugi^1,2 (1. IMRAM, Tohoku Univ., 2. Grad. Sch. Sci., Tohoku Univ.)

[Lang.] English

5:20 PM - 5:30 PM

[D1441-1vn-08] Development of a host-guest-driven molecular system for reversible regulation of duplex hybridization

^○Takeyuki Yao^1,2, Hidenori Okamura^1,2, Fumi Nagatsugi^1,2 (1. IMRAM, Tohoku Univ., 2. Grad. Sch. Sci., Tohoku Univ.)

[Lang.] Japanese

Break （5:30 PM - 5:40 PM）

5:40 PM - 5:50 PM

[D1441-1vn-09] Complete Chemical Synthesis of mRNA with Chemical Capping Reaction as the key step.

^○Kazuya Ogawa¹, Masahito Inagaki¹, Zhenmin Li¹, Naoko Abe¹, Yasuaki Kimura¹, Hiroshi Abe^1,2 (1. The Univ. of Nagoya, 2. iGCORE)

[Lang.] Japanese

5:50 PM - 6:00 PM

[D1441-1vn-10] Synthesis of nucleoside oligophosphates by electrophilic activation of phosphorothioate.

^○Shogo Hasegawa¹, Masahito Inagaki¹, Shunichi Kato¹, Li Zhenmin¹, Yasuaki Kimura¹, Hiroshi Abe^1,2,3 (1. Graduate School of Science, Nagoya University, 2. CREST, Japan Science and Technology Agency, 3. Institute for Glyco-core Research (iGCORE))

[Lang.] Japanese

6:00 PM - 6:10 PM

[D1441-1vn-11] Enzymatic Incorporation of an Environmentally Responsive Fluorescent Thymidine Analogue into DNA

^○Tomotaka Kumagai¹, Daisuke Hori¹, Kenta Ishida^4,5, Yuuya Kasahara^5,4, Satoshi Obika^4,5,6, Hiroshi Sugiyama³, Soyoung Park² (1. Kyoto University, 2. Immunology Frontier Research Center (iFReC), Osaka University, 3. Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, 4. Grad. Sch. Pharm. Sci., Osaka Univ., 5. NIBIOHN, 6. OTRI, Osaka Univ.)

[Lang.] Japanese

6:10 PM - 6:20 PM

[D1441-1vn-12] Visible light photodimerization of stilbene by DNA with Ru(II) complex

^○Azuma Hidenori¹, Asanuma Hiroyuki¹, Hiromu Kashida¹ (1. Grad. Sch. of Eng., Nagoya Univ.)

[Lang.] Japanese

6:20 PM - 6:30 PM

[D1441-1vn-13] Synthesis and cross-linking studies on diazirine-modified photo-cross-linking oligonucleotides

^○Daiki Unita¹, Kentaro Kobata¹, Kazuki Matsubara¹, Machiko Kitamura¹, Kazuya Matsuo¹, Tomonori Waku¹, Akio Kobori¹ (1. Kyoto Instituite of Technology)

[Lang.] Japanese

6:30 PM - 6:40 PM

[D1441-1vn-14] L-aTNA modified with 8-Pyrenylvinyl adenine for photo-responsive triplex formation

^○Keito Hirano¹, Keiji Murayama¹, Hiroyuki Asanuma¹ (1. Nagoya university)

[Lang.] Japanese

6:40 PM - 6:50 PM

[D1441-1vn-15] Synthesis and evaluation of macrocyclic hexaoxazole compounds as G-quadruplex multivalent ligands

^○Shogo Sasaki¹, Yue Ma², Mao Hanbin³, Masayuki Tera¹, Kazuo Nagasawa¹ (1. Tokyo Univ. Agri. Tech., 2. Tokyo Med. Dent. Univ., 3. Kent State Univ.)

[Lang.] Japanese

Academic Program [Oral A]

[D1411-2am] 17. Biofunctional Chemistry, Biotechnology

Thu. Mar 23, 2023 9:00 AM - 11:40 AM D1411 (1411, Bldg. 14 [1F])

Chair: Akira Onoda, Shinya Ariyasu

+Add all to schedule

9:00 AM - 9:10 AM

[D1411-2am-01] Screening of inhibitory peptides that bind to Bcl-2 mutants by using the a stapledα-helix peptide library displayed on phage

^○Akira Miyaji¹, Riku Motegi¹, Hisakazu Mihara¹, Hiroshi Tsutsumi¹ (1. Tokyo Institute of Technology, School of Life Science and Technology)

[Lang.] Japanese

9:10 AM - 9:20 AM

[D1411-2am-02] Construction of a galactose-modified peptide phage library and screening of peptide ligands binding to galectin-3

^○Yue Qiu¹, Mihara Hisakazu¹, Tsutsumi Hiroshi¹ (1. Tokyo Institute of Technology, School of Life Science and Technology)

[Lang.] English

9:20 AM - 9:30 AM

[D1411-2am-03] Construction of an Artificial Photoredox Biocatalyst by Conjugating a Peptide with a Ru Complex

^○Ryusei Kano¹, Koji Oohora¹, Takashi Hayashi¹ (1. Osaka Univ.)

[Lang.] Japanese

9:30 AM - 9:40 AM

[D1411-2am-04] Screening for Non-heme Iron Enzymes toward Catalytic Intramolecular Hydroarylation of Alkynes

^○Haruka Nishiwaki¹, Shunsuke Kato¹, Takashi Hayashi¹ (1. Osaka University)

[Lang.] Japanese

9:40 AM - 9:50 AM

[D1411-2am-05] Library Screening of Hemoprotein-based Artificial Metalloenzymes Reconstituted with Iron Porphycene for Olefin Cyclopropanation

^○Kevin Hamdani¹, Shunsuke Kato¹, Takashi Hayashi¹ (1. Osaka University)

[Lang.] English

9:50 AM - 10:00 AM

[D1411-2am-06] Construction of a cyclized cytochrome c₅₅₅ trimer using Sortase A

^○Gissi Novientri¹, Kodai Fujiwara¹, Tsuyoshi Mashima¹, Naoya Kobayashi¹, Shun Hirota¹ (1. Division of Materials Science, Nara Institute of Science and Technology)

[Lang.] English

10:00 AM - 10:10 AM

[D1411-2am-07] Search of oligomeric antibody light chains focused on amino acid residues important for 3D domain swapping

^○Shohei Yamaguchi¹, Takahiro Sakai¹, Tsuyoshi Mashima¹, Naoya Kobayashi¹, Emi Hifumi², Taizo Uda², Shun Hirota¹ (1. Nara Institute of Science and Technology, 2. Oita University)

[Lang.] Japanese

10:10 AM - 10:20 AM

[D1411-2am-08] Dependence of ammonium on the activity of lanthanide dependent methanol dehydrogenase from Methylosinus trichosporium OB3b

^○Yosuke Horikoshi¹, Wataru Shiina¹, Hidehiro Ito¹, Toshiaki Kamachi¹ (1. Tokyo institute of technology)

[Lang.] Japanese

Break （10:20 AM - 10:30 AM）

10:30 AM - 10:40 AM

[D1411-2am-09] Site-specific Dual Modification of Albumin Using 1H-1,2,3-Triazole-4-carbaldehyde as an N-Terminus Modification Reagent

^○Yuya Maeda¹, Akira Onoda^1,2 (1. Grad. Sch. Env. Sci., Hokkaido Univ., 2. Faculty of Env. Earth Sci., Hokkaido Univ.)

[Lang.] Japanese

10:40 AM - 10:50 AM

[D1411-2am-10] Visualization of Green Fluorescent Protein Immobilized on a Glass Substrate using N-Terminal Modification with a Triazole Carbaldehyde Derivative

^○Yan Zhang¹, Dong Zhang¹, Akira Onoda^1,2, Vasudevanpillai Biju^1,3 (1. Grad. School Env. Sci., Hokkaido Univ., 2. Faculty of Env. Earth Sci., Hokkaido Univ., 3. Res. Inst. Electr. Sci., Hokkaido Univ.)

[Lang.] Japanese

10:50 AM - 11:00 AM

[D1411-2am-11] Immobilizing Proteins on the Surface of Resin Using Triazolecarbaldehyde Reagents

^○Wang Shiyu¹, Akira Onoda^1,2 (1. Graduate School of Environmental Science, Hokkaido University, 2. Faculty of Environmental Earth Science, Hokkaido University)

[Lang.] English

11:00 AM - 11:10 AM

[D1411-2am-12] Construction of Artificial Metalloproteins by Utilizing Heme Acquisition Protein from Acinetobacter baumannii

^○Viet Quoc Nguyen¹, Shinya Ariyasu¹, Yuichiro Aiba¹, Osami Shoji¹ (1. Grad. Sch. of Sci., Nagoya Univ.)

[Lang.] English

11:10 AM - 11:20 AM

[D1411-2am-13] Development of a bacteriostatic method delivering metal complexes modified with antimicrobial peptide into cells via the heme acquisition system of Pseudomonas aeruginosa

^○Hiroki Matsui¹, Yuichiro Aiba¹, Nanaka Watanabe¹, Shinya Ariyasu¹, Osami Shoji¹ (1. The Univ. of Nagoya)

[Lang.] Japanese

11:20 AM - 11:30 AM

[D1411-2am-14] Asymmetric synthesis with a novel Baeyer-Villiger monooxygenases from Fusarium sp. NBRC 109816

^○Lan Huong Le Viet¹, Hiroumi Nemoto¹, Mayumi Tamura¹, Tomoko Matsuda¹ (1. Tokyo Institute of Technology)

[Lang.] English

11:30 AM - 11:40 AM

[D1411-2am-15] Determination of kinetic parameters of dehalogenation reaction catalyzed by fluoroacetate dehalogenase using an isothermal titration calorimetry

^○Takashi Nakamura¹, Yuudai Shioda¹, Eiji Nakata², Takashi Morii² (1. Nagahama Institute of Bio-Science and Technology, 2. Kyoto University)

[Lang.] Japanese

Academic Program [Oral A]

[D1441-2am] 17. Biofunctional Chemistry, Biotechnology

Thu. Mar 23, 2023 9:00 AM - 11:40 AM D1441 (1441, Bldg. 14 [4F])

Chair: Masayuki Tera, Tatsuya Nishihara

+Add all to schedule

9:00 AM - 9:10 AM

[D1441-2am-01] The Effects of Loop Region on G-quadruplex Folding Mechanism

^○Minori Nakata¹, Naoki Kosaka¹, Daisuke Miyoshi¹ (1. The Univ. of Konan)

[Lang.] Japanese

9:10 AM - 9:20 AM

[D1441-2am-02] Interaction and photo-induced electron transfer between DNAs and a cationic phthalocyanine derivative

Shiori Homma¹, ^○Atsuya Momotake¹, Takahisa Ikeue², Yasuhiko Yamamoto¹ (1. University of Tsukuba, 2. Shimane University)

[Lang.] Japanese

9:20 AM - 9:30 AM

[D1441-2am-03] Photo-decomposition of G-quadruplex DNAs with anionic Zn(Ⅱ) phthalocyanine

^○Yusuke Odahara¹, Atsuya Momotake², Yasuhiko Yamamoto² (1. Grad. Sch., Univ. of Tsukuba, 2. Univ. of Tsukuba)

[Lang.] Japanese

9:30 AM - 9:40 AM

[D1441-2am-04] Serendipitous discovery of E. coli-like microrod formation by self-assembly of DNA-β-sheet peptide conjugates

^○Kazunori MATSUURA Matsuura¹, Aoi Nakatsu¹, Hiroshi Inaba¹ (1. Tottori University)

[Lang.] Japanese

9:40 AM - 9:50 AM

[D1441-2am-05] Unique triplex structure formed by acyclic nucleic acid

^○Yukiko Kamiya¹, Siyuan Lao¹, Hiroyuki Asanuma¹ (1. Nagoya University)

[Lang.] Japanese

9:50 AM - 10:00 AM

[D1441-2am-06] Effects of DNA sequences and cosolutes on the formation of hexagonal DNA assemblies

^○Tetsunao Makino¹, Makiko Tanaka¹ (1. Grad. Sch. Info. Sci., UEC.)

[Lang.] Japanese

10:00 AM - 10:10 AM

[D1441-2am-07] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (84) : Fluorescence light-up through binding of dye molecules to specific loop sequences of i-motif DNA

^○Sinjan Das¹, Shuntaro Takahashi¹, Naoki Sugimoto^1,2 (1. Konan Univ. FIBER, 2. Konan Univ. FIRST)

[Lang.] English

10:10 AM - 10:20 AM

[D1441-2am-08] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (85): Investigation of accumulation mechanism for RNA G-quadruplexes with G₄C₂ repeats and poly-dipeptides

^○Tatsuya Ohyama¹, Hisae Tateishi-Karimata¹, Shigenori Tanaka², Naoki Sugimoto^1,3 (1. FIBER, Konan Univ., 2. Grad. Sch. Sys. Inf., Kobe Univ., 3. FIRST, Konan Univ.)

[Lang.] English

Break （10:20 AM - 10:30 AM）

10:30 AM - 10:40 AM

[D1441-2am-09] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (83) :Bulge-containing G-quadruplexes is a new target motif to regulate gene expression in therapeutics

^○Sunipa Sarkar¹ (1. FIBER, Konan University)

[Lang.] English

10:40 AM - 10:50 AM

[D1441-2am-10] Development of a dual-site-recognition type telomeric G4 ligand with photo-cross-linking group

^○Kazuki Yanagita¹, Shogo Sasaki¹, Yue Ma², Kazunori Ikebukuro¹, Takatsugu Hirokawa³, Masayuki Tera¹, Kazuo Nagasawa¹ (1. Tokyo University of Agriculture and Technology, 2. Tokyo Medical and Dental University, 3. Division of Biomedical Science, University of Tsukuba))

[Lang.] Japanese

10:50 AM - 11:00 AM

[D1441-2am-11] Improved DNA Recognition Through Invasion Complex Formation Using Multiple Pairs of Parallel-Type PNAs

^○Naoya Mochizuki¹, Masanari Shibata¹, Yuichiro Aiba¹, Kota Ito¹, Shinya Ariyasu¹, Osami Shoji¹ (1. Nagoya University)

[Lang.] Japanese

11:00 AM - 11:10 AM

[D1441-2am-12] Synthesis of chemical probes for the analysis of the dynamic forming behavior of G- quadruplexes

^○Haruki Fujita¹, Naruyuki Watatani¹, Syogo Sasaki¹, Yue Ma², Masayuki Tera¹, Kazuo Nagasawa¹ (1. Tokyo University of Agriculture and Technology, 2. Tokyo Medical and Dental University)

[Lang.] Japanese

11:10 AM - 11:20 AM

[D1441-2am-13] Analysis of Liquid-liquid phase separation inducing ability with macrocyclic hexaoxazole-type G-quadruplex ligands

^○Akari Oyama¹, Shogo Sasaki¹, Masayuki Tera¹, Kazuo Nagasawa¹ (1. Tokyo University of Agriculture and Technology)

[Lang.] Japanese

11:20 AM - 11:30 AM

[D1441-2am-14] Development of G-quadruplex forming sequence predictor and application to the SARS-CoV-2 genome sequences.

^○Rena Nohara¹, Junya Kitamura¹, Hiina Seino¹, Shogo Sasaki¹, Akira Shiraishi², Kazunori Ikebukuro¹, Masayuki Tera¹ (1. Tokyo University of Agriculture and Technology, 2. Suntory Foundation for Life Sciences)

[Lang.] Japanese

11:30 AM - 11:40 AM

[D1441-2am-15] Elucidation of mechanism and function of TERRA aggregates

^○keishi deguchi¹, tatsuki masuzawa², kentaro takahama¹, Ayako Okushima¹, riki kurokawa³, Takanori Oyoshi^2,1,4 (1. Graduate school of integrated Science and Technology, Shizuoka University, 2. Graduate School of Science and Technology, Shizuoka University, 3. Research Center for Genomic Medicine, Saitama Medical University, 4. Research Institute of Green Science and Technology, Shizuoka University)

[Lang.] Japanese

Academic Program [Oral A]

[D1411-2pm] 17. Biofunctional Chemistry, Biotechnology

Thu. Mar 23, 2023 1:30 PM - 3:40 PM D1411 (1411, Bldg. 14 [1F])

Chair: Takayuki Miki, Yutaro Saito

+Add all to schedule

1:30 PM - 1:40 PM

[D1411-2pm-01] Design of a DNP-NMR molecular probe for the detection of dipeptidyl peptidase-4 based on the mechanism of substrate recognition

^○Akihito Goto¹, Hiroyuki yatabe¹, Kazutoshi Yamamoto², Murali Krishna Cherukuri², Yutaro Saito¹, Shinsuke Sando¹ (1. The university of Tokyo, 2. National Institutes of Health)

[Lang.] Japanese

1:40 PM - 1:50 PM

[D1411-2pm-02] Development of Ca²⁺-dependent an oxidative folding catalyst for controlling protein quality in the endoplasmic reticulum

^○Rumi Mikami¹, Kenta Arai¹ (1. Tokai University)

[Lang.] Japanese

1:50 PM - 2:00 PM

[D1411-2pm-03] A chemigenetic red fluorescent calcium ion indicator based on a fluorescent protein and a synthetic chelator

^○Shosei Imai¹, Wenchao Zhu¹, Takuya Terai¹, Robert Earl Campbell^1,2 (1. Department of Chemistry, Graduate School of Science, The University of Toky, 2. Department of Chemistry, University of Alberta)

[Lang.] English

2:00 PM - 2:10 PM

[D1411-2pm-04] Cleavage of influenza RNA using artificial RNA-cleaving enzymes in animal cells

^○Tomoaki Mori¹, Koichi Mori¹, Takashi Sera¹ (1. Okayama University)

[Lang.] Japanese

2:10 PM - 2:20 PM

[D1411-2pm-05] Importance of the flanking repeats R1’ and R8’ of the human Pumilio1 protein in RNA Binding

^○Moe Sakashita¹, Kento Nakamura¹, Serika Ohno¹, Tomoaki Mori¹, Koichi Mori¹, Takashi Sera¹ (1. Okayama university)

[Lang.] Japanese

2:20 PM - 2:30 PM

[D1411-2pm-06] Development of a site-specific gene insertion method using a artificial zinc-finger protein

^○Mika Sumitomo¹, Tatsuhiko Sumikawa¹, Serika Ohno¹, Tomoaki Mori¹, Koichi Mori¹, Takashi Sera¹ (1. Okayama University)

[Lang.] Japanese

Break （2:30 PM - 2:40 PM）

2:40 PM - 2:50 PM

[D1411-2pm-07] Ubiquitin-ligand chimera peptides inducing targeted protein degradation

^○Jotaro Miyamoto¹, Takafumi Furuhata¹, Akimitsu Okamoto¹ (1. The University of Tokyo)

[Lang.] Japanese

2:50 PM - 3:00 PM

[D1411-2pm-08] Intracellular photoactivation of proteins using sterically bulky caging

^○Yamamoto Ryotaro¹, Satoshi Yamaguchi¹, Akimitsu Okamoto¹ (1. The university of Tokyo)

[Lang.] Japanese

3:00 PM - 3:10 PM

[D1411-2pm-09] Synthesis and Oxygen Binding Ability of Core-Shell Structured Stroma-Free Hemoglobin Nanoparticle

^○Koki Takamine¹, Watau Okamoto¹, Natsumi Kohyama¹, Teruyuki Komatsu¹ (1. Chuo university)

[Lang.] Japanese

3:10 PM - 3:20 PM

[D1411-2pm-10] Synthesis and Cytotoxicity of 2-Methyl-2-Polyoxazoline-Conjugated Asparaginase

^○Takuma Shoji¹, Marika Ishimaru¹, Taiga Yamada¹, Teruyuki Komatsu¹ (1. Chuo University)

[Lang.] Japanese

3:20 PM - 3:30 PM

[D1411-2pm-11] Effect of lipid moiety on cellular uptake of artificial lipid-modified proteins

^○Kazuki Uchida¹, Rie Wakabayashi¹, Masahiro Goto¹, Naofumi Shimokawa², Takagi Masahiro², Noriho Kamiya¹ (1. Faculty of Engineering, Kyushu University, 2. School of Materials Science, Japan Advanced Institute of Science and Technology)

[Lang.] Japanese

3:30 PM - 3:40 PM

[D1411-2pm-12] Enzymatic metabolic reactions compartmentalized in liposome with a skeletal DNA nanostructure

^○Futa Komatsubara¹, Peng Lin¹, Eiji Nakata¹, Takashi Morii¹ (1. Kyoto University)

[Lang.] Japanese

Academic Program [Oral A]

[D1441-2pm] 17. Biofunctional Chemistry, Biotechnology

Thu. Mar 23, 2023 1:40 PM - 3:40 PM D1441 (1441, Bldg. 14 [4F])

Chair: Koji Oohora, Noriyuki Asakura

+Add all to schedule

1:40 PM - 1:50 PM

[D1441-2pm-01] Development of a drug release system using iron oxide nanoparticles and thermo-responsive polymers

^○Yuka Takashima¹, Hiroyuki Nakamura^1,2, Satoshi Okada^1,2 (1. School of Life Science and Technology, Tokyo Institute of Technology, 2. Laboratory for Chemistry and Life Science, Tokyo Institute of Technology)

[Lang.] Japanese

1:50 PM - 2:00 PM

[D1441-2pm-02] Near-infrared light drive of muscle tissue using upconversion nanoparticles

^○Daisuke Maemura¹, The Son Le¹, Mari Takahashi¹, Kazuaki Matsumura¹, Shinya Maenosono¹ (1. School of Materials Science, JAIST)

[Lang.] Japanese

2:00 PM - 2:10 PM

[D1441-2pm-03] Preparation of a hydrogel containing an artificial trimeric peptide as a cross-linker and evaluation of its mechanical properties

^○Yuri Hidaka¹, Takumi Ikeda, Koji Oohora¹, Takashi Hayashi¹ (1. Osaka Univ.)

[Lang.] Japanese

2:10 PM - 2:20 PM

[D1441-2pm-04] In vivo imaging of tumor hypoxia utilizing fluorescence extinction by autoxidation of 9-aminoanthracene

^○Yosuke Uchiyama¹, Fumitaka Kawakami¹, Hiroko Maruyama¹ (1. Kitasato University)

[Lang.] Japanese

2:20 PM - 2:30 PM

[D1441-2pm-05] Discrimination of apoptotic K562 phase-contrast images by AI

^○Yuki Kikuchi¹, Satoshi Sasaki¹, Yuki Okuhashi², Hiroaki Ishihata¹, Misato Kashiba¹ (1. Graduate School, Tokyo University of Technology, 2. Tokyo University of Technology)

[Lang.] Japanese

Break （2:30 PM - 2:40 PM）

2:40 PM - 2:50 PM

[D1441-2pm-06] Synthetic studies on UDP analogs having modified uracil moieties toward discoveries of potent inhibitors of UDP-Glc: glycoprotein glucosyltransferase (UGGT)

^○Yusaku Sasae¹, Junpei Abe¹, Yasuhiro Kajihara^1,2, Yukishige Itou^1,2,3 (1. Grad. Sch. Sci., Osaka Univ., 2. FRC, Grad. Sch. Sci., Osaka Univ., 3. RIKEN CPR)

[Lang.] Japanese

2:50 PM - 3:00 PM

[D1441-2pm-07] Synthetic Studies on Multivalent Complexes (Ⅵ): Functionalization of carbosilanes and verification of the condensation reaction

^○Toshiki Koarai¹, Takahiko Matsushita^1,2,3, Tetsuo Koyama¹, Ken Hatano^1,2,3, Koji Matsuoka^1,2,3 (1. Graduate School of Science and Engineering, Saitama University, 2. Advanced institute of innovative Technology, Saitama University, 3. Strategic Research Center, Saitama University)

[Lang.] English

3:00 PM - 3:10 PM

[D1441-2pm-08] Synthesis and studies on benzaldehyde derivatives that can convert lysine residues of target protein to solvatochromic fluorophores

^○Mariko Aso¹, Yixuan LIU¹, Yukiko Abe¹, Kaori Tabata¹ (1. Kyushu University)

[Lang.] Japanese

3:10 PM - 3:20 PM

[D1441-2pm-09] Microbial degradation process of biodegradable polymer directly monitored by QCM and electrochemistry

^○Takuma Otsuki¹, Yasumasa Takenaka², Tomohiro Hiraishi², Hideki Abe², Noriyuki Asakura¹ (1. Tokyo Institute of Technology, 2. RIKEN)

[Lang.] Japanese

3:20 PM - 3:30 PM

[D1441-2pm-10] Cultivation of iron-oxidizing bacteria using unutilized resources and carbon dioxide fixation

^○Kaisho Sasaki¹, Mami Hanao², Satoshi Sasaki¹ (1. Graduate School, Tokyo University of Technology, 2. Tokyo University of Technology)

[Lang.] Japanese

3:30 PM - 3:40 PM

[D1441-2pm-11] Synthetic Studies of Zwitterion-Modified Cyclodextrins (Ⅱ)
Synthesis and Introduction of Sulfobetaine Modification Groups

^○Kanta Koizumi¹, Takahiko Matsushita^1,2,3, Tetsuo Koyama¹, Ken Hatano^1,2,3, Koji Matsuoka^1,2,3 (1. Grad. Sci.&Engin. Saitama University, 2. Adv. Inst. Innov. Tech. Saitama University, 3. Strategic Res. Ctr. Saitama University)

[Lang.] Japanese

Academic Program [Oral A]

[D1411-2vn] 17. Biofunctional Chemistry, Biotechnology

Thu. Mar 23, 2023 4:10 PM - 6:20 PM D1411 (1411, Bldg. 14 [1F])

Chair: Hiroshi Inaba, Masayuki Tera

+Add all to schedule

4:10 PM - 4:20 PM

[D1411-2vn-01] Liposome Deformation based on reversible assembly and disassembly of peptide nanofibers by photoisomerization

^○Yingbing Liang¹, Shigesaburo Ogawa¹, Hiroshi Inaba¹, Kazunori Matsuura¹ (1. Grad. Sch. of Eng., Tottori Univ.)

[Lang.] Japanese

4:20 PM - 4:30 PM

[D1411-2vn-02] Budding into the interior of giant liposome by artificial viral capsid bearing alkyl-anchor

^○Miu Hirahara¹, Kentarou Sakamoto¹, Hiroto Furukawa¹, Hiroshi Inaba¹, Kazunori Matsuura¹ (1. Graduate School of Engineering, Tottori University)

[Lang.] Japanese

4:30 PM - 4:40 PM

[D1411-2vn-03] Quantum chemical calculations of the mineralization reactions of phospholipids

^○Yunhao Cheng¹, Emilio Satoshi Hara², Nilson Kunioshi¹ (1. Waseda University, 2. Okayama University)

[Lang.] Japanese

4:40 PM - 4:50 PM

[D1411-2vn-04] Preparation of tubular phospholipid membranes induced by self-assembling peptides and application to single-molecule analysis of membrane curvature sensing proteins.

^○Ryu Ishizaka¹, Anjyu Kawakita¹, Noriyuki Uchida¹, Takahiro Muraoka^1,2 (1. Tokyo University of Agriculture and Technology, 2. KISTEC)

[Lang.] Japanese

4:50 PM - 5:00 PM

[D1411-2vn-05] Design of Membrane-Contracting Molecular Machine to Induce Fusion of Liposomal Membrane and Its Application to Intracellular Delivery

^○Ken Yoshizawa¹, Noriyuki Uchida¹, Takahiro Muraoka^1,2 (1. Tokyo University of Agriculture and Technology, 2. KISTEC)

[Lang.] Japanese

5:00 PM - 5:10 PM

[D1411-2vn-06] Synthesis of Azobenzene Dimers and Morphological Changes of Lipid Bilayers by Photoisomerization

^○Moeha Dei¹, Hidefumi Iwashita¹, Kosei Shioji¹ (1. Fukuoka University)

[Lang.] Japanese

Break （5:10 PM - 5:20 PM）

5:20 PM - 5:30 PM

[D1411-2vn-07] Cellulose solubility and toxicity of aqueous pyrrolidinium hydroxide (I) -Effect of alkyl chain length on toxicity-

^○Miki SAITOH¹, Ena HARA¹, Rinako SUZUKI¹, Tamao SAITO¹, Yuko TAKEOKA¹, Masahiro RIKUKAWA¹, Masahiro FUJITA¹ (1. Sophia University)

[Lang.] Japanese

5:30 PM - 5:40 PM

[D1411-2vn-08] Synthetic studies of Porphyrin Polymers having carbohydrate moieties
Synthesis and physical properties of sugar containing porphyrin polymers

^○Yuta Komano¹, Koji Matsuoka^1,2,3, Ken Hatano^1,2,3, Takahiko Matsusita^1,2,3, Tetsuo Koyama¹ (1. Graduate School of Science and Engineering, Saitama University, 2. Advanced Institute of Innovative Technology, Saitama University, 3. Health Sciences and Technology Research Area, Strategic Research Center, Saitama University)

[Lang.] Japanese

5:40 PM - 5:50 PM

[D1411-2vn-09] Surface properties of hydrophobic glycosaminoglycan monolayers and preparation of their nanofilms

^○Takuharu Shimizu¹, Hiroki Kajiwara¹, Toshiaki Mori¹ (1. Tokyo Inst. of Technol.)

[Lang.] Japanese

5:50 PM - 6:00 PM

[D1411-2vn-10] Formation of protein-lipid-cation triple complex in the light-driven proton pump bacteriorhodopsin.

^○Kentaro Nakayama¹, Masanao Kinosita¹, Nobuaki Matsumori¹ (1. Graduate School of Science, Kyusyu University)

[Lang.] Japanese

6:00 PM - 6:10 PM

[D1411-2vn-11] Formation of cell aggregates by azide-labeled cells and water-soluble cyclooctadiyne and analysis of the gene fluctuation related to cell adhesion

^○Moeka Yoshinaga¹, Fumiya Sato¹, Kohei Kitagawa¹, Hitoshi Takemae², Masayuki Tera¹ (1. Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2. Graduate School of Agriculture, Tokyo University of Agriculture and Technology)

[Lang.] Japanese

6:10 PM - 6:20 PM

[D1411-2vn-12] Formation of the cell aggregates composed by azide-modified hyaluronic acid and water-soluble cyclooctadiyne

^○Fumiya Sato¹, Moeka Yoshinaga¹, Yuichiro Oki², Natsuko Inagaki², Taichi Ito², Masayuki Tera¹ (1. Faculty of Engineering, Tokyo University of Agriculture and Technology, 2. Graduate School of Engineering, The University of Tokyo)

[Lang.] Japanese

Academic Program [Oral A]

[D1441-2vn] 17. Biofunctional Chemistry, Biotechnology

Thu. Mar 23, 2023 4:10 PM - 6:30 PM D1441 (1441, Bldg. 14 [4F])

Chair: Koji Miki, Masahumi Minoshima

+Add all to schedule

4:10 PM - 4:20 PM

[D1441-2vn-01] Development of a K⁺-responsive MRI probe

^○Satoshi Okada^1,2, Shota Saiki², Rie Ryoke³, Akira Sumiyoshi⁴, Ryuta Kawashima³, Hiroyuki Nakamura^1,2 (1. Laboratory for Chemistry and Life Science, Tokyo Tech, 2. School of Life Science and Technology, Tokyo Tech, 3. Institute of Development, Aging and Cancer, Tohoku Univ, 4. QST)

[Lang.] Japanese

4:20 PM - 4:30 PM

[D1441-2vn-02] Development of ¹⁹F MRI Probe labeling β-lactamase

^○Hiroto Fukuda¹, Masafumi Minoshima^1,2, Kazuya Kikuchi^1,3 (1. Graduate School of Engineering, Osaka Univ., 2. JST PRESTO, 3. Immunology Frontier Research Center, Osaka Univ.)

[Lang.] Japanese

4:30 PM - 4:40 PM

[D1441-2vn-03] Development of elastic perfluorocarbon-encapsulated polymer nanoparticles for ¹⁹F MRI contrast agents

^○Yuki Konishi¹, Fuminori Sugihara^2,3, Masafumi Minoshima^1,4, Kohei Fujihara⁵, Takayuki Uchihashi⁵, Kazuya Kikuchi^1,2 (1. Graduate School of Engineering, Osaka Univ., 2. Immunology Frontier Research Center, Osaka Univ., 3. Research Institute for Microbial Diseases, Osaka University, 4. JST PRESTO, 5. Graduate School of Science, Nagoya University)

[Lang.] Japanese

4:40 PM - 4:50 PM

[D1441-2vn-04] Development of Ultrasmall Core-shell Silica Nanoparticles
for ¹⁹F Magnetic Resonance Imaging

^○YUE WU¹, Masafumi Minoshima^1,4, Fuminori Sugihara^3,2, Kazuya Kikuchi^1,2 (1. Graduate School of Engineering, Osaka University, 2. Osaka University Immunology Frontier Research Center, 3. Osaka University Research Institute for Microbial Diseases, 4. JST PRESTO)

[Lang.] English

Break （4:50 PM - 5:00 PM）

5:00 PM - 5:10 PM

[D1441-2vn-05] Development of palmitoylation-based small-molecule fluorescent stains for live-cell Golgi imaging

^○Masaru Yoshikawa¹, Shunsuke Sawada¹, Shinya Tsukiji¹ (1. Nagoya Institute of Technology)

[Lang.] Japanese

5:10 PM - 5:20 PM

[D1441-2vn-06] Development of novel genetically encoded fluorescent probes for visualizing phosphatidylinositol 4-phosphate in living cells

^○Moeka Ajiki¹, Masaru Yoshikawa¹, Fubito Nakatsu², Shinya Tsukiji¹ (1. Grad. Sch. of Eng., Nagoya Inst. of Tech., 2. Grad. Sch. of Med. and Dent. Sci., Niigata Univ.)

[Lang.] Japanese

5:20 PM - 5:30 PM

[D1441-2vn-07] Fluorescence imaging of peroxisomal beta-oxidation pathway with quinone methide-releasing probe

^○Yuya Matsuo¹, Shohei Uchinomiya¹, Tomoki Nagaura¹, Akio Ojida¹ (1. Pharmaceutical sciense, Kyushu University)

[Lang.] Japanese

5:30 PM - 5:40 PM

[D1441-2vn-08] Multi-functional Phospha-rhodamines synthesized through catalytic arylation on the phosphorous atom

^○Yuichi Asada¹, Masayasu Taki², Shigehiro Yamaguchi^1,2 (1. Graduate School of Science, Nagoya University, 2. Institute of Transformative Bio-Molecules, Nagoya University)

[Lang.] Japanese

Break （5:40 PM - 5:50 PM）

5:50 PM - 6:00 PM

[D1441-2vn-09] Quantification of Bio-Reductants by Redox Kinetic Analysis Based on Control of Fluorescence Blinking

^○Shotaro Tsuchitori¹, Yuki Yonezawa¹, Shuya Fan¹, Atsushi Maruyama², Mamoru Fujitsuka¹, Kiyohiko Kawai² (1. SANKEN, Osaka Univ., 2. School of Life Science and Technology, Tokyo Tech)

[Lang.] Japanese

6:00 PM - 6:10 PM

[D1441-2vn-10] Development of a phenylboronic acid-BODIPY conjugate for selective detection of fructose

Gengo Kashiwazaki^1,2, ^○Marina Sumida¹, Ryo Omikawa¹, Ryo Watanabe², Akihiro Nishikawa², Koyori Kawamura³, Takao Hibi³, Takashi Kitayama^1,2 (1. Graduate School of Agriculture, Kindai University, 2. Faculty of Agriculture, Kindai University, 3. Department of Bioscience and Biotechnology, Fukui Prefectural University)

[Lang.] Japanese

6:10 PM - 6:20 PM

[D1441-2vn-11] Evaluation of Photochemical Characteristics of Aβ Aggregates with Near-infrared Fluorescent Cyanine Dyes for Photoacoustic Imaging

^○Yukina Inoue¹, Hisatsugu Yamada², Yu Kimura¹, Risako Miura¹, Teruyuki Kondo¹ (1. Graduate School of Engineering, Kyoto University, 2. Graduate School of Technology, Industrial and Social Sciences, Tokushima University)

[Lang.] Japanese

6:20 PM - 6:30 PM

[D1441-2vn-12] Development of Raman Molecular Probes for Multicomponent Biomolecular Analysis Using Thin-Layer Chromatography

^○Rika Tsukame¹, Tatsuya Nishihara¹, Kazuhito Tanabe¹ (1. Aoyama Gakuin University)

[Lang.] Japanese

Academic Program [Oral A]

[D1411-3am] 17. Biofunctional Chemistry, Biotechnology

Fri. Mar 24, 2023 9:00 AM - 11:30 AM D1411 (1411, Bldg. 14 [1F])

Chair: Koji Matsuoka, Ryo Okamoto

+Add all to schedule

9:00 AM - 9:10 AM

[D1411-3am-01] Semisynthetic Study of Interleukin-21 using New Peptide Preparation Method

^○Nana Izawa¹, Yuta Maki^1,2, Ryo Okamoto^1,2, Yasuhiro Kajihara^1,2 (1. Dept. Chem., Grad. Sch. Sci., Osaka Univ., 2. FRC, Grad. Sch. Sci., Osaka Univ.)

[Lang.] Japanese

9:10 AM - 9:20 AM

[D1411-3am-02] Synthetic study of an artificial mini-glycoprotein

^○Harumi Nishikawa¹, Ryo Okamoto^1,2, Yuta Maki^1,2, Yasuhiro Kajihara^1,2 (1. Grad. Sch. Sci., Osaka Univ., 2. FRC, Grad. Sch. Sci., Osaka Univ.)

[Lang.] Japanese

9:20 AM - 9:30 AM

[D1411-3am-03] Synthetic study of hydrophobic glycoprotein modified with a fluoroamino acid

^○Ryota Sakurai¹, Ryo Okamoto^1,2, Yuta Maki^1,2, Yasuhiro Kajihara^1,2 (1. Grad. Sch. Sci., Osaka Univ., 2. FRC, Grad. Sch. Sci., Osaka Univ.)

[Lang.] Japanese

9:30 AM - 9:40 AM

[D1411-3am-04] Synthetic study on plant glycosphingolipid GIPC

^○Yuta Umemura¹, Naoko Komura², Akihiro Imamura^1,2, Hideharu Ishida^1,2, Rumana Yesmin Hasi³, Toshiki Ishikawa⁴, Tamotsu Tanaka³, Hiromune Ando², Hide-Nori Tanaka² (1. Dept. Appl. Bioorg. Chem., Gifu Univ., 2. iGCORE, Gifu Univ., 3. Fac. Biosci. Biotech., Tokushima Univ., 4. Grad. Sch. Sci. Eng., Saitama Univ.)

[Lang.] Japanese

9:40 AM - 9:50 AM

[D1411-3am-05] Systematic synthetic studies of heparan sulfate partial disaccharide structures containing GlcN-IdoA sequences.

^○Ryoma Hayase¹, Kensuke Sameshima¹, Masahiro Wakao¹, Yasuo Suda¹ (1. Kagoshima University)

[Lang.] Japanese

9:50 AM - 10:00 AM

[D1411-3am-06] Development of hybrid-binding probe for Ces1d-mediated endo-glycosidase activity

^○Akito Taira¹, Taiki Kuribara¹, Kiichiro Totani¹ (1. Department of Science and Technology, Seikei)

[Lang.] Japanese

10:00 AM - 10:10 AM

[D1411-3am-07] Protecting-group-free phosphate cross-coupling reaction enables highly efficient synthesis of ADP-ribose related molecule

^○Rui Hagino¹, Naoko Komura², Akihiro Imamura^1,2, Hideharu Ishida^1,2, Hiromune Ando^1,2, Hide-Nori Tanaka^1,2 (1. United Grad. Sch. Agr. Sci., Gifu Univ., 2. iGCORE, Gifu Univ.)

[Lang.] Japanese

Break （10:10 AM - 10:20 AM）

10:20 AM - 10:30 AM

[D1411-3am-08] Chemical modification and functionalization of trehalose (II): Application for Click chemistry

^○YU YANG¹, Takahiro Matsushita^2,4,3, Tetsuo Koyama², Ken Hatano^2,4,3, Koji Matsuoka^2,4,3 (1. The Univ. of Saitama, 2. Graduate School of Science and Engineering, Saitama University, 3. Strategic Research Center, Saitama Univ. , 4. Advanced Institute of Innovative Technology, Saitama Univ.)

[Lang.] Japanese

10:30 AM - 10:40 AM

[D1411-3am-09] Synthetic of N-Glycolylneuraminic Acid Derivatives (VI): ~ Investigation of the multivalency of sialyl lactose~

^○Jianhong Zhang¹, Tetsuo Koyama¹, Takahiro Matsushita^1,2,3, Ken Hatano^1,2,3, Koji Matsuoka^1,2,3 (1. Graduate School of Science and Engineering,Saitama University, 2. Advanced Institute of Innovative Technology,Saitama University, 3. Health Sciences and Technology Research Area, Strategic Research Center, Saitama University)

[Lang.] Japanese

10:40 AM - 10:50 AM

[D1411-3am-10] Synthetic studies of prodrugs using the dissociation mechanism of sialic acid by NA (IX): Comparison of Drug Release of Two Types of Prodrugs

^○Ryo Uchiyama¹, Takahiko Matsushita^1,2, Tetsuo Koyamayama¹, Ken Hatano^1,2, Koji Matsuoka^1,2 (1. Graduate School of Science & Engineering, Saitama University, 2. Advanced Institute of Innovative Technology The Univ. of Saitama)

[Lang.] English

10:50 AM - 11:00 AM

[D1411-3am-11] Cryopreservation of cells by anchoring zwitterionic polymer

^○Yuya Matsuda¹, Takeru Ishizaki¹, Kenji Takahashi¹, Eishu Hirata², Kosuke Kuroda¹ (1. Faculty of Biological Science and Technology, Institute of Science and Engineering, 2. Cancer Research Institute, Kanazawa University)

[Lang.] Japanese

11:00 AM - 11:10 AM

[D1411-3am-12] Development of cell-designer molecules for accumulation of retinal pigment epithelial cells in the target area by injection

^○Yusuke Kajiura¹, Kazuki Moroishi¹, Michiya Matsusaki¹ (1. The Univ. of Osaka)

[Lang.] Japanese

11:10 AM - 11:20 AM

[D1411-3am-13] Synthesis of Alendronic acid and Phenylalanine conjugated Poly(γ-Glutamic) acid for 3D bioprinting.

^○Sukulya Bunuasunthon¹, Masahiko Nakamoto¹, Michiya Matsusaki¹ (1. Grad. Sch. Eng. Osaka Univ.)

[Lang.] English

11:20 AM - 11:30 AM

[D1411-3am-14] Preparation of Clearing polymers for Deep Observation of Living Three-dimensional Tissues

^○Kaori Hayazaki¹, Daisuke Tomioka¹, Michiya Matsusaki¹ (1. Grad. Sch. Eng. Osaka Univ.)

[Lang.] Japanese

Academic Program [Oral A]

[D1441-3am] 17. Biofunctional Chemistry, Biotechnology

Fri. Mar 24, 2023 9:00 AM - 11:30 AM D1441 (1441, Bldg. 14 [4F])

Chair: Kazuhito Tanabe, Yusuke Kitamura

+Add all to schedule

9:00 AM - 9:10 AM

[D1441-3am-01] Analyses of intracellular uptake pathways and dynamics of acyclic artificial nucleic acids SNA and L-aTNA

Yukiko Kamiya¹, ^○Kiyoka Sakashita¹, Hiroyuki Asanuma¹ (1. Nagoya University)

[Lang.] Japanese

9:10 AM - 9:20 AM

[D1441-3am-02] In vivo suppression of target gene expression by XNAs Staple based on RNA hacking technology

^○Tomoki Kida¹, Yousuke Katsuda¹, Takuto Kamura¹, Yuusuke Kitamura¹, Masaki Hagihara², Shin-ichi Sato³, Ihara Toshihiro¹ (1. Faculty of Advance Science and Technology, Kumamoto University, 2. Faculty of Science and Technology, Hirosaki University, 3. Institute for Chemical Research, Kyoto University)

[Lang.] Japanese

9:20 AM - 9:30 AM

[D1441-3am-03] Novel mechanism of gene expression control technology using RNA hacking

^○Yua Itsuki¹, Yousuke Katsuda¹, Yusuke Kitamura¹, Toshihiro Ihara¹ (1. Kumamoto Univ. )

[Lang.] Japanese

9:30 AM - 9:40 AM

[D1441-3am-04] Photo-oxidation in the vicinity of nucleic acid double helix (1) photo-oxidation property of guanine in DNA duplex by ¹O₂

^○Takashi Kanamori¹, Shota Kaneko¹, Hideya Yuasa¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

9:40 AM - 9:50 AM

[D1441-3am-05] Photooxidation in the vicinity of nucleic acid double helix (2) photo-oxidation property of guanine in RNA duplex by ¹O₂ and application to photo-antisense method

^○Shota Kaneko¹, Takashi Kanamori¹, Hideya Yuasa¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

Break （9:50 AM - 10:00 AM）

10:00 AM - 10:10 AM

[D1441-3am-06] Synthesis of base-modified nucleoside triphosphates containing 1,2-diol and their substrate properties in polymerase reactions

^○Rei Katou¹, Kouki Tajiri¹, Erika Nagatani¹, Hidekazu Hoshino², Yuuya Kasahara^2,3, Satoshi Obika^3,2,4, Hiroto Fujita¹, Masayasu Kuwahara¹ (1. Nihon University, 2. NIBIOHN, 3. Grad. Sch. Pharm. Sci., Osaka Univ., 4. OTRI, Osaka Univ.)

[Lang.] Japanese

10:10 AM - 10:20 AM

[D1441-3am-07] The examination of membrane permeability and translation activity of chemically modified mRNA

^○Satomi Sugiyama¹, Haruka Hiraoka¹, Yuko Nakashima¹, Naoko Abe¹, Zhenmin Li¹, Shunichi Kato¹, Yuki Yoshida¹, Mikiya Kase¹, Hiroshi Abe^1,2,3 (1. Nagoya University, 2. Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology (JST CREST), 3. Institute for Glyco-core Research (iGCORE))

[Lang.] Japanese

10:20 AM - 10:30 AM

[D1441-3am-08] Analysis of G-quadruplex Binding Protein of EWS for Transcriptional Regulation of TERRA

^○Luthfi Lulul Ulum¹, Maiko Yamanashi², Haruka Morikawa², Takanori Oyoshi^1,2,3 (1. Graduate School of Science and Technology, Shizuoka University, 2. Graduate School of Integrated Science and Technology, Shizuoka University, 3. Research Institute of Green Science and Technology, Shizuoka University)

[Lang.] English

10:30 AM - 10:40 AM

[D1441-3am-09] Identification and performance evaluation of amplifier elements in isothermal nucleic acid amplification reactions

^○Chihiro Kubo¹, Hiroto Fujita¹, Masayasu Kuwahara¹ (1. Nihon university)

[Lang.] Japanese

Break （10:40 AM - 10:50 AM）

10:50 AM - 11:00 AM

[D1441-3am-10] Aggregates Formation between CUG Repeat RNA Sequences and MBNL1

^○Surachada Chuaychob¹, Wanqing Hou¹, Musashi Shimizu¹, Shun Nakano¹, Arivazhagan Rajendran¹, Eiji Nakata¹, Takashi Morii¹ (1. Institue of Advanced Energy, Kyoto University)

[Lang.] English

11:00 AM - 11:10 AM

[D1441-3am-11] Evaluation of the reactivity of TopoisomeraseⅠ to G-quadruplex DNA

^○Ryoma Yokosawa¹, Koya Sakamoto¹, Takanori Oyoshi^1,2,3 (1. Graduate school of Integrated Science and Technology , Shizuoka University, 2. Graduate School of Science and Technology, Shizuoka University, 3. Research Institute of Green Science and Technology, Shizuoka University)

[Lang.] Japanese

11:10 AM - 11:20 AM

[D1441-3am-12] Development of G4 binding protein regulating G4-containing promoter

^○Maiko Yamanashi¹, Yamato Karikome¹, Akinori Ishihara¹, Takanori oyoshi^1,2,3 (1. Graduate school of integrated Science and Technology, Shizuoka University, 2. Graduate school of Science and Technology, Shizuoka University, 3. Research Institute of Green Science and Technology, Shizuoka University)

[Lang.] Japanese

11:20 AM - 11:30 AM

[D1441-3am-13] Small molecules regulate liquid-liquid phase separation induced by G-quadruplex

^○Nagisa Takamiya¹, Mitsuki Tsuruta¹, Yoshiki Hashimoto¹, Keiko Kawauchi¹, Daisuke Miyoshi¹ (1. Konan University, FIRST)

[Lang.] Japanese

Academic Program [Oral A]

[D1411-3pm] 17. Biofunctional Chemistry, Biotechnology

Fri. Mar 24, 2023 1:10 PM - 3:40 PM D1411 (1411, Bldg. 14 [1F])

Chair: Gosuke Hayashi, Takahiro Nakama

+Add all to schedule

1:10 PM - 1:20 PM

[D1411-3pm-01] Invention of microtubule-associated peptides inspired by microtubule superstructure

^○Yuna Ogura¹, Hiroshi Inaba¹, Arif Md. Rashedul Kabir², Akira Kakugo², Kazuki Sada², Kazunori Matsuura¹ (1. Tottori Univ., 2. Hokkaido Univ.)

[Lang.] Japanese

1:20 PM - 1:30 PM

[D1411-3pm-02] Optical manipulation of microtubule structures using conjugate of Tau-derived peptide with light-responsive tetrameric protein

^○Soei Watari¹, Hiroshi Inaba¹, Takashi Iwasaki², Rashedul Kabir Md. Arif³, Akira Kakugo³, Kazuki Sada³, Kazunori Matsuura¹ (1. Graduate school of engineering, Tottori university, 2. Graduate School of Agricultural Sciences, Tottori University, 3. Faculty of Science, Hokkaido University)

[Lang.] Japanese

1:30 PM - 1:40 PM

[D1411-3pm-03] Evaluation of weak protein–sugar interactions induced by confinement in giant hollow coordination complexes

^○Miri Tadokoro¹, Takahiro Nakama¹, Makoto Fujita^1,2 (1. The University of Tokyo, 2. Institute for Molecular Science)

[Lang.] Japanese

1:40 PM - 1:50 PM

[D1411-3pm-04] NMR Observation of Hysteretic Behaviour in Solvent-Induced Protein Unfolding/Refolding Processes via Encapsulation in a Coordination Cage

^○Anouk Rossen¹, Takahiro Nakama¹, Maho Yagi-Utsumi², Daishi Fujita³, Koichi Kato², Makoto Fujita^1,2 (1. The University of Tokyo, 2. Institute for Molecular Science, 3. iCeMS, Kyoto University)

[Lang.] English

1:50 PM - 2:00 PM

[D1411-3pm-05] Creation of enzyme-reactive peptide co-assemblies with controlled surface charge

^○Yuki Nabae¹, Ayato Higuchi¹, Rie Wakabayashi¹, Noriho Kamiya^1,2, Masahiro Goto^1,2 (1. Kyushu University, 2. Kyushu University Center of Future Chemistry)

[Lang.] Japanese

Cancelled

2:00 PM - 2:10 PM

[D1411-3pm-06] Physical properties of phase separating peptide condensates rationally designed from phase separating protein

^○Atsumi Hando¹, Maulana Ariefai¹, Nanako Iwaki¹, Saori Kanbayashi¹, Ryotaro Koike², Keisuke Ikeda³, Kiyoto Kamagata¹ (1. Tohoku Univ., 2. Nagoya Univ., 3. Univ. Toyama)

[Lang.] Japanese

2:10 PM - 2:20 PM

[D1411-3pm-07] Fast and Accurate Prediction of Intrinsically Disordered Protein by Protein Language Model

^○Shijie Xu¹, Akira Onoda^1,2 (1. Graduate School of Environmental Science, Hokkaido Univ., 2. Faculty of Environmental Earth Science, Hokkaido Univ.)

[Lang.] English

Break （2:20 PM - 2:30 PM）

2:30 PM - 2:40 PM

[D1411-3pm-08] Inhibition of protein aggregation using a zwitterion

^○Ai Tajiri¹, Takeru Ishizaki¹, Kazuaki Ninomiya², Takahashi Kenji¹, Kosuke Kuroda¹ (1. Faculty of Biological Science and Technology, Institute of Science and Engineering, Kanazawa University, 2. Institute for Frontier Science Initiative, Kanazawa University)

[Lang.] Japanese

2:40 PM - 2:50 PM

[D1411-3pm-09] Chemical protein synthesis by DNA scaffold-mediated peptide ligation

^○Yuya Takahashi¹, Shingo Mizushima¹, Masataka Ikawa¹, Gosuke Hayashi¹, Hiroshi Murakami^1,2 (1. Nagoya University, 2. Institute of Nano-Life-Systems, Innovation for Future Society, Nagoya University)

[Lang.] Japanese

2:50 PM - 3:00 PM

[D1411-3pm-10] One-pot peptide ligation and desulfurization utilizing thiocholine

^○Sae Suzuki¹, Naoki Kamo, Yuya Nakajima¹, Gosuke Hayashi¹, Hiroshi Murakami¹ (1. Nagoya University)

[Lang.] Japanese

3:00 PM - 3:10 PM

[D1411-3pm-11] Chemical synthesis and evaluation of D-monobody binding to MCP-1 protein

^○Toshinori Naito¹, Sayaka Miura¹, Gosuke Hayashi¹, Hiroshi Murakami^1,2 (1. The Univ. of Nagoya, 2. Institute of Nano-Life-Systems, Innovation for Future Society, Nagoya University)

[Lang.] Japanese

3:10 PM - 3:20 PM

[D1411-3pm-12] Luminescence detection of cytoplasmic peptide:N-glycanase activity inside cells using engineered split inteins

^○Tsuyoshi Takahashi¹, Tatsuya Uchibayashi¹, Satoshi Takahashi¹, Nozomi Ishii¹, Ichiro Matsuo¹, Yukiko Yoshida², Tadashi Suzuki³ (1. Gunma University, 2. Tokyo Metropolitan Institute of Medical Science, 3. RIKEN)

[Lang.] Japanese

3:20 PM - 3:30 PM

[D1411-3pm-13] Synthesis of glycopeptides and investigation of their reactivities toward cytoplasmic peptide:N-glycanase and endo-β-N-acetylglucosaminidase

^○Haruka Inoue¹, Satoshi Takahashi¹, Nozomi Ishii¹, Ichirou Matsuo¹, Yukiko Yoshida², Tadashi Suzuki³, Tsuyoshi Takahashi¹ (1. Gunma University, 2. Tokyo Metropolitan Institute of Medical Science, 3. RIKEN)

[Lang.] Japanese

3:30 PM - 3:40 PM

[D1411-3pm-14] Construction of a ligand screening method using split intein and reconstitution of kanamycin kinase

^○Kana Nobusawa¹, Yutaro Watanabe¹, Tsuyoshi Takahashi¹ (1. Gunma University)

[Lang.] Japanese

Academic Program [Oral A]

[D1441-3pm] 17. Biofunctional Chemistry, Biotechnology

Fri. Mar 24, 2023 1:20 PM - 3:40 PM D1441 (1441, Bldg. 14 [4F])

Chair: Hiroshi Inaba, Tomohiro Doura

+Add all to schedule

1:20 PM - 1:30 PM

[D1441-3pm-01] Tumor antigen-displayed enveloped viral replica (1): Creation and nanostructure evaluation of the complex

^○Hiroto Furukawa¹, Keita Ito², Hiroshi Inaba¹, Yoshiyuki Manabe², Shino Ohshima³, Yoshie Kametani³, Koichi Fukase², Kazunori Matsuura¹ (1. Grad. Sch. of Eng., Tottori Univ., 2. Grad. Sch. of Sci., Osaka Univ., 3. Sch. of Med., Tokai Univ.)

[Lang.] Japanese

1:30 PM - 1:40 PM

[D1441-3pm-02] Tumor-antigen-displayed enveloped viral replica (2): Immunological evaluation

^○Keita Ito¹, Hiroto Furukawa², Yoshiyuki Manabe¹, Shino Ohshima³, Yoshie Kametani³, Kazuya Kabayama¹, Hiroshi Inaba², Kazunori Matsuura², Koichi Fukase¹ (1. Grad. Sch. of Sci., Osaka Univ., 2. Grad. Sch. of Eng., Tottori Univ., 3. Sch. of Med., Tokai Univ.)

[Lang.] Japanese

1:40 PM - 1:50 PM

[D1441-3pm-03] Functional oligonucleotide for the aminopeptidase activity analysis

^○Reoto Mio¹, Tatsuya Nishihara¹, Kazuhito Tanabe¹ (1. Aoyama Gakuin University)

[Lang.] Japanese

1:50 PM - 2:00 PM

[D1441-3pm-04] Functionalization of nitroimidazole groups that accumulated in hypoxic cells by click reaction

^○Tatsuya Ozasa¹, Kazuhito Tanabe¹, Tatsuya Nishihara¹ (1. Aoyama Gakuin University)

[Lang.] Japanese

Break （2:00 PM - 2:10 PM）

2:10 PM - 2:20 PM

[D1441-3pm-05] Photoaffinity Labeling of His Tag-Fused Proteins on Cell Surface and Its Application to Proximity Labeling

^○Haruka Suetsugu¹, Takuya Imamura¹, Naoki Zenmyo¹, Kaori Tabata¹, Shohei Uchinomiya¹, Akio Ojida¹ (1. Graduate School of Pharmaceutical sciences, Kyushu University)

[Lang.] Japanese

2:20 PM - 2:30 PM

[D1441-3pm-06] Development of a novel noncovalent fluorogenic probe labeling system for live-cell imaging

^○Shun Ito¹, Keita Tsutsui¹, Moeka Ajiki¹, Masaru Yoshikawa¹, Natsumi Hukaya¹, Shinya Tsukiji¹ (1. Grad. Sch. of Eng., Nagoya Inst. of Tech.)

[Lang.] Japanese

2:30 PM - 2:40 PM

[D1441-3pm-07] Development of a protein labeling system based on a small molecule-binding artificial monobody

^○Natsumi Fukaya¹, Masaru Yoshikawa¹, Tatsuyuki Yoshi¹, Syun Umemoto², Nariaki Tsuzuki², Tomoshige Fujino², Gosuke Hayashi², Hiroshi Murakami^2,3, Shinya Tsukiji¹ (1. Graduate School of Engineering, Nagoya Institute of Technology, 2. Graduate School of Engineering, Nagoya University, 3. Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University)

[Lang.] Japanese

2:40 PM - 2:50 PM

[D1441-3pm-08] Development of Artificial Siderophore-Iron Complexes for Selective Fluorescent Labeling of Microorganisms.

^○Reon Mori¹ (1. Nagoya Institute of Technology)

[Lang.] Japanese

Break （2:50 PM - 3:00 PM）

3:00 PM - 3:10 PM

[D1441-3pm-09] Synthesis of novel molecular photoswitches for nucleic acids consisting of o-fluoroazobenzene

^○Yuka Kajihara¹, Chikara Dohno^1,2, Kazuhiko Nakatani^1,2 (1. SANKEN, Osaka University, 2. CREST, JST)

[Lang.] Japanese

3:10 PM - 3:20 PM

[D1441-3pm-10] Development of mutant metabotropic glutamate receptor subtype 1 (mGlu1) selective silent ligands for in vivo regulation of mGlu1

^○Tomohiro Doura¹, Shuntaro Kashiwa¹, Kanta Hasegawa¹, Yuya Matsuba¹, Shigeki Kiyonaka¹ (1. Nagoya University)

[Lang.] Japanese

3:20 PM - 3:30 PM

[D1441-3pm-11] Selective activation of mGlu1 mutants by derivatization of allosteric inhibitors

^○Takumi Kondo¹, Kanta Hasegawa¹, Tomohiro Douura¹, Shigeki Kiyonaka¹ (1. The Univ. of Nagoya)

[Lang.] Japanese

3:30 PM - 3:40 PM

[D1441-3pm-12] Regulation of adenosine A_2A receptor using photoresponsive A_2A agonists

^○Yuya Matsuba¹, Harufumi Suzuki¹, Tomohiro Doura¹, Shigeki Kiyonaka¹ (1. Nagoya University)

[Lang.] Japanese

Academic Program [Oral A]

[D1441-3vn] 17. Biofunctional Chemistry, Biotechnology

Fri. Mar 24, 2023 4:10 PM - 6:10 PM D1441 (1441, Bldg. 14 [4F])

Chair: Koki Kamiya, Takanori Matsumaru

+Add all to schedule

4:10 PM - 4:20 PM

[D1441-3vn-01] Protein translocation into the giant asymmetric unilamellar vesicle using cell penetrating peptide – protein complexes

^○Akari Miwa¹, Koki Kamiya¹ (1. Graduate School of Science and Technology, Gunma Univ.)

[Lang.] Japanese

4:20 PM - 4:30 PM

[D1441-3vn-02] Protein accumulation on the membrane of asymmetric lipid-protein vesicles

^○Masato Suzuki¹, Koki Kamiya¹ (1. Gunma Univ)

[Lang.] Japanese

4:30 PM - 4:40 PM

[D1441-3vn-03] Function of mechanosensitive channels in asymmetric lipid-protein vesicles toward the construction of a membrane tension sensing system

^○Kotaro Baba¹, Masato Suzuki², Koki Kamiya² (1. School of Science and Technology, Gunma University, 2. Graduate School of Science and Technology, Gunma University)

[Lang.] Japanese

4:40 PM - 4:50 PM

[D1441-3vn-04] More easily way of finding a lipid raft and analyses of enzymatic hydrolysis of lipid raft surface at single molecular level.

^○Junji HORIKE¹, Kento AKIYAMA¹, Toshiaki MORI¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

4:50 PM - 5:00 PM

[D1441-3vn-05] Surface coating of an algal cell with long DNA strands elongated by a DNA polymerase for functionalization.

^○YINGQI MU¹, Yuseke Yonamine², Hideyuki Mitomo², Kuniharu Ijiro² (1. Hokkaido university, 2. Research Institute for Electronic Science, Hokkaido University (RIES, Hokkaido Univ.))

[Lang.] English

5:00 PM - 5:10 PM

[D1441-3vn-06] Apoptotic activity of ceramide derivatives and its molecular mechanism

^○Koya Tsujimura¹, Masanao Kinoshita¹, Nobuaki Matsumori¹ (1. Graduate School of Science, Kyusyu University)

[Lang.] Japanese

Break （5:10 PM - 5:20 PM）

5:20 PM - 5:30 PM

[D1441-3vn-07] Extraction of characteristic conformers of high mannose-type oligosaccharides based on molecular simulation data

^○Yue Zhang¹, Takumi Yamaguchi^1,2,3 (1. School of Materials Science, Japan Advanced Institute of Science and Technology, 2. Graduate School of Pharmaceutical Sciences, Nagoya City University, 3. Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences)

[Lang.] Japanese

5:30 PM - 5:40 PM

[D1441-3vn-08] Three-dimensional structural analysis of Lewis X-related oligosaccharides by ion mobility spectrometry

^○Hao Feng¹, Hiroaki Tatsuoka¹, Takumi Yamaguchi^1,2,3 (1. School of Materials Science, Japan Advanced Institute of Science and Technology, 2. Graduate School of Pharmaceutical Sciences, Nagoya City University, 3. Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences)

[Lang.] Japanese

5:40 PM - 5:50 PM

[D1441-3vn-09] Elucidation of the importance of acetamide groups in the substrate recognition of ENGase by unnatural-type core risaccharides.

^○Naoya Tajima¹, Kota Tabikawa¹, Naoki Saito¹, Junpei Nireki¹, Taiki Kuribara¹, Kiichiro Totani¹ (1. Department of Science and Technology, Seikei University)

[Lang.] Japanese

5:50 PM - 6:00 PM

[D1441-3vn-10] Correlation analysis of endoplasmic reticulum stress and glycan processing using reconstituted glycan profiles

^○Juri Hata¹, Taiki Kuribara¹, Kiichiro Totani¹ (1. Department of Science and Technology, Seikei University)

[Lang.] Japanese

6:00 PM - 6:10 PM

[D1441-3vn-11] Development of a fluorescence monitoring method for cancer cell surface calreticulin

^○Yuka Kobayashi¹, Taiga Kojima¹, Taiki Kuribara¹, Kiichiro Totani¹ (1. Department of science and technology, Seikei University)

[Lang.] Japanese

Academic Program [Oral A]

[D1411-3vn] 17. Biofunctional Chemistry, Biotechnology

Fri. Mar 24, 2023 4:10 PM - 6:50 PM D1411 (1411, Bldg. 14 [1F])

Chair: Hiroshi Tsutsumi, Tomomi Yoshiyama

+Add all to schedule

4:10 PM - 4:20 PM

[D1411-3vn-01] Chemical synthesis of the selenocysteine-substituted epidermal growth factor

^○Toshiki Takei¹, Hideaki Tanaka¹, Nobuaki Okumura¹, Toshifumi Takao¹, Luis Moroder², Hironobu Hojo¹ (1. Institute for Protein Research, Osaka University, 2. Max Planck Institute of Biochemistry)

[Lang.] Japanese

4:20 PM - 4:30 PM

[D1411-3vn-02] Stapled peptide-modified silica nanoparticles for inhibition of Bcl-2

^○Riku Motegi¹, Akira Miyaji¹, Hisakazu Mihara¹, Hiroshi Tsutsumi¹ (1. Tokyo Institute of Technology, School of Life Science and Technology)

[Lang.] Japanese

4:30 PM - 4:40 PM

[D1411-3vn-03] Fluorescent silica nanoparticles modified with galactose ligands for analysis of galactose-binding proteins

^○Ukyo Matsuura¹, Hisakazu Mihara¹, Hiroshi Tsutsumi¹ (1. Tokyo Institute of Technology, School of Life Science and Technology)

[Lang.] Japanese

4:40 PM - 4:50 PM

[D1411-3vn-04] Development of a next-generation alkylhydrazine linker applicable to Fmoc solid-phase synthesis

^○Takaya YAMAMOTO¹, Kohei SATO¹, Tetsuo NARUMI¹, Nobuyuki MASE¹ (1. Shizuoka university)

[Lang.] Japanese

4:50 PM - 5:00 PM

[D1411-3vn-05] Selection of SARS-CoV-2 spike glycoprotein-binding peptides using phage display method

^○Nene Suzuki¹, Teruhiko Matsubara¹, Toshinori Sato¹ (1. Keio University)

[Lang.] Japanese

5:00 PM - 5:10 PM

[D1411-3vn-06] Functional analysis of GM1 mimetic peptides obtained by biopanning in acoustically levitated droplets

^○Akiko Yoshida¹, Teruhiko Matsubara¹, Toshinori Sato¹ (1. Faculty of Science and Technology, Keio University)

[Lang.] Japanese

5:10 PM - 5:20 PM

[D1411-3vn-07] Electrochemical Detection of Influenza Virus by Peptide-immobilized Silver Nanoplate Composite Electrodes

^○Shota Tanaka¹, Teruhiko Matsubara¹, Kengo Ito², Toshinori Sato¹ (1. Faculty of Science and Technology, Keio University, 2. Ito Research Institute Co., Ltd)

[Lang.] Japanese

Break （5:20 PM - 5:30 PM）

5:30 PM - 5:40 PM

[D1411-3vn-08] Preparation and efficiency evaluation of three-enzyme complexes for controlling biological catalytic reactions

^○Aoi Mameuda¹, Koki Kamiya¹ (1. Graduate School of Science and Technology, Gunma University)

[Lang.] Japanese

5:40 PM - 5:50 PM

[D1411-3vn-09] Method of reconstitution of β-barrel-modified nanopore protein into the liposome

^○Toshiyuki Tosaka¹, Koki Kamiya¹ (1. Gunma Univ.)

[Lang.] Japanese

5:50 PM - 6:00 PM

[D1411-3vn-10] Development of organic solvent-tolerant bromoperoxidase by attaching hydrophilic oligopeptides

^○Hideyasu China¹, Takuya Matsuura¹, Takashi Nakamura¹ (1. Nagahama Institute of Bio-Science and Technology)

[Lang.] Japanese

6:00 PM - 6:10 PM

[D1411-3vn-11] Structural and functional modification of chlorophylls by protist

Hitoshi Tamiaki¹, ^○Hayate Nomura¹, Mitsuaki Hirose¹, Yuichoro Kashiyama² (1. Ritsumeikan University, 2. Fukui University of Technology)

[Lang.] Japanese

6:10 PM - 6:20 PM

[D1411-3vn-12] Photoinduced oxidation with phenosafranin immobilized ITO electrode and malate dehydrogenase

^○Hironao Ando¹, Noriyuki Asakura¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

6:20 PM - 6:30 PM

[D1411-3vn-13] Construction of a photocatalytic hydrogen evolution system using red blood cell ghosts

^○Taiga SAKAMOTO¹, Tomomi Koshiyama¹ (1. Ritsumeikan university)

[Lang.] Japanese

6:30 PM - 6:40 PM

[D1411-3vn-14] Aggregation of the CERT START domain and its prevention

^○Shiomi Fujii¹, Takashi Kodama², Toshihiko Sugiki², Kentaro Hanada³, Fujiwara Toshimichi², Chojiro Kojima^1,2 (1. Yokohama National University, 2. Osaka University, 3. National Institute of Infectious Diseases)

[Lang.] Japanese

6:40 PM - 6:50 PM

[D1411-3vn-15] Alternation of Intramolecular Hydrogen-Bonding Network Dependent on Oligomeric States of a Sodium Ion-Pumping Protein

^○Taiki Nakamura¹, Misao Mizuno², Akihiro Otomo², Hideki Kandori³, Yasuhisa Mizutani² (1. Sch.Sci.,Osaka Univ., 2. Grad.Sch.Sci.,Osaka Univ., 3. Grad.Sch.Eng.,Nagoya Inst.Tech.)

[Lang.] Japanese

Academic Program [Oral A]

[D1411-4am] 17. Biofunctional Chemistry, Biotechnology

Sat. Mar 25, 2023 9:00 AM - 11:20 AM D1411 (1411, Bldg. 14 [1F])

Chair: Kazuma Amaike, Yoshitaka Koseki

+Add all to schedule

9:00 AM - 9:10 AM

[D1411-4am-01] Enhanced Cd²⁺/Zn²⁺ Selectivity in Fluorescent Bisquinoline-Type Tetradentate Ligands with o-Phenylenediamine Skeleton

^○Miho Nagaoka¹, Kaho Kawakami¹, Yuji Mikata (1. Nara Women's University)

[Lang.] Japanese

9:10 AM - 9:20 AM

[D1411-4am-02] Development of Cadmium Ion Sensor by Introduction of Methoxy Groups into Bisquinoline-Based Tetradentate Ligands Exhibiting Selective Fluorescence Response to Zinc Ion

^○Saori Yasuda¹, Marin Tanaka¹, Aya Tsuruta¹, Taeka Hagiwara¹, Yuji Mikata¹ (1. Nara Women's University)

[Lang.] Japanese

9:20 AM - 9:30 AM

[D1411-4am-03] Development of a cell manipulation system using chemically-responsive synthetic protein assemblies

^○Yoko Fukaya¹, Masaru Yoshikawa¹, Sachio Suzuki¹, Shinya Tsukiji¹ (1. Grad. Sch. of Eng., Nagoya Inst. of Tech.)

[Lang.] Japanese

9:30 AM - 9:40 AM

[D1411-4am-04] Intracellular binding and photoswitching properties of anti-azobenzene artificial antibodies

^○Tomoki Miyazaki¹, Kai Tahara², Masaru Yoshikawa², Natsumi Fukaya², Tatsuyuki Yoshii², Mamoru Funane³, Naoya Murata³, Tomoshige Fujino³, Gosuke Hayashi³, Hiroshi Murakami^3,4, Shinya Tsukiji² (1. Nagoya Institute of Technology, 2. Graduate School of Engineering, Nagoya Institute of Technology, 3. Graduate School of Engineering, Nagoya University, 4. Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University)

[Lang.] Japanese

Break （9:40 AM - 9:50 AM）

9:50 AM - 10:00 AM

[D1411-4am-05] Selective removal of B800 bacteriochlorophyll a pigments from peripheral light-harvesting proteins of purple photosynthetic bacteria and characterization of the B800-free proteins

^○Yoshitaka Saga¹, Syota Kawato¹, Kohei Hamanishi¹ (1. Kindai University)

[Lang.] Japanese

10:00 AM - 10:10 AM

[D1411-4am-06] Biotin-Liposomal Modification of Prodrug Nanoparticles and Evaluation of their Active Targeting Ability

^○Musashi Kazui¹, Farsai Taemaitree², Beatrice Fortuni³, Yoshitaka Koseki¹, Anh T. N. Dao⁴, Ryuju Suzuki¹, Hiroshi Uji-i^2,3, Hitoshi Kasai¹ (1. Tohoku University, 2. Hokkaido University, 3. KU Leuven, 4. Nagasaki University)

[Lang.] Japanese

10:10 AM - 10:20 AM

[D1411-4am-07] Development of SN-38 prodrug nanoparticles selectively activated by glutathione in cancerous cells

^○Asuka Mizutani¹, Aki Shibata¹, Keita Tanita¹, Ryuju Suzuki¹, Anh Thi Ngoc Dao^1,2, Yoshitaka Koseki¹, Hitoshi Kasai¹ (1. Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2. Graduate School of Engineering, Nagasaki University )

[Lang.] Japanese

10:20 AM - 10:30 AM

[D1411-4am-08] Synthesis of SN-38 prodrugs activated by light irradiation and evaluation of their anticancer activity

^○Momoka Kiyohara¹, Yoshitaka Koseki¹, Ryuzyu Suzuki¹, Anh Thi Ngoc Dao^1,2, Hitoshi Kasai¹ (1. Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2. Graduate School of Engineering, Nagasaki University)

[Lang.] Japanese

Break （10:30 AM - 10:40 AM）

10:40 AM - 10:50 AM

[D1411-4am-09] Activity control of P(V)porphyrin photosensitizers by the pH-responsive electron donors and hydrophobic substituents

^○Kazutaka HIRAKAWA¹, Shinya Yamaoka¹, Shigetoshi Okazaki² (1. Shizuoka Univ., 2. Hamamatsu Univ. Sch. of Med.)

[Lang.] Japanese

10:50 AM - 11:00 AM

[D1411-4am-10] Synthesis of amphiphilic aromatic polymers for biological applications

^○Tomoya Nakagomi¹, Shusei Fujiki¹, Akiko Yagi¹, Kazuma Amaike¹, Kenichiro Itami¹ (1. Nagoya university )

[Lang.] Japanese

11:00 AM - 11:10 AM

[D1411-4am-11] Design of stimuli-responsive luciferin reacted with cathepsin B under weak acidic conditions

^○Kotone Yanagisawa¹, Kei Nishida¹, Masayasu Mie¹, Eiry Kobatake¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

11:10 AM - 11:20 AM

[D1411-4am-12] Identification and Characterization of Peptides that Bind to a Homogeneous Oligomer with Uniform Monomer Sequence and Molecular Weight

^○Hyu Murakami¹, Toshiki Sawada¹, Yusuke Saito², Yoshiko Miura², Yu Hoshino², Takeshi Serizawa¹ (1. Sch. Mater. & Chem. Tech., Tokyo Tech, 2. Grad. Sch. Eng., Kyusyu Univ.)

[Lang.] Japanese

Academic Program [Oral A]

[D1441-4am] 17. Biofunctional Chemistry, Biotechnology

Sat. Mar 25, 2023 9:00 AM - 11:40 AM D1441 (1441, Bldg. 14 [4F])

Chair: Keiji Murayama, Yasuaki Kimura

+Add all to schedule

9:00 AM - 9:10 AM

[D1441-4am-01] Mitigating the toxicity of gapmer-type antisense oligonucleotide by using acyclic nucleic acid

^○Masaya Higuchi¹, yukiko kamiya¹, hiroyuki asanuma¹ (1. Grad. Sch. Eng., Nagoya Univ.)

[Lang.] Japanese

9:10 AM - 9:20 AM

[D1441-4am-02] The interaction analysis of ¹⁵N-labeled naphthyridine derivatives with repeat DNA by NMR

^○Noriaki Sugiura¹, Takeshi Yamada¹, Shuhei Sakurabayashi¹, Kazuhiko Nakatani¹ (1. SANKEN, Osaka University)

[Lang.] Japanese

9:20 AM - 9:30 AM

[D1441-4am-03] Radiolytic reduction of copper ion and DNA cleavage

^○Kousuke Meisho¹, Tatsuya Nishihara¹, Kazuhito Tanabe¹ (1. Graduate School of Science and Engineering Aoyama Gakuin University)

[Lang.] Japanese

9:30 AM - 9:40 AM

[D1441-4am-04] Fluorescence characterization of Thioflavin T-chelator conjugates

^○Tomoko Wariishi¹, Yuka Kataoka¹, Hiroto Fujita¹, Masayasu Kuwahara¹ (1. Nihon University)

[Lang.] Japanese

9:40 AM - 9:50 AM

[D1441-4am-05] Development of a method for chemical synthesis of long DNAs in a photolithographic flow system

^○Teruyuki Okaniwa¹, Koichiro Miyauchi¹, Aoma Yoshida¹, Yuya Okawara¹, Koki Maruyama¹, Ishin Ono¹, Tatsuhiro Yokoyama¹, Akihiro Ohkubo¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

9:50 AM - 10:00 AM

[D1441-4am-06] Novel Design Strategy of DNA-Artificial Nucleic Acid Chimera Toward Enhancement of Target RNA Cleavage Activities: Modification Effects of DNA Moiety upon Complex Stabilities and Activity

^○Nozomu Ishiwata¹, Masahito Inagaki², Masaki Nishijima¹, Hironori Hayashi³, Yasuyuki Araki¹, Eiichi Kodama³, Takehiko Wada¹ (1. IMRAM, Tohoku Univ., 2. Nagoya Univ., 3. IRIDeS, Tohoku Univ.)

[Lang.] Japanese

10:00 AM - 10:10 AM

[D1441-4am-07] Construction of Catalytic Target RNA Cleavage Function Installed Chimeric Artificial Nucleic Acids (CANA) toward Development of COVID-19 Treatments-I : Design, Synthesis, and in vitro Properties

^○Kazutoshi Fujita¹, Nozomu Ishiwata¹, Masahito Inagaki², Masaki Nishijima¹, Hironori Hayashi³, Yu Mikame⁴, Yasuyuki Araki¹, Tsuyoshi Yamamoto⁴, Asako Yamayoshi⁴, Eiichi Kodama³, Takehiko Wada¹ (1. IMRAM, Tohoku Univ., 2. Nagoya Univ., 3. IRIDeS, Tohoku Univ., 4. Grad. Sch. Biomed. Sci., Nagasaki Univ.)

[Lang.] Japanese

Break （10:10 AM - 10:20 AM）

10:20 AM - 10:30 AM

[D1441-4am-08] Construction of DNA libraries with random sequences using chemically modified primers and ligation reactions.

^○Naho Takahashi¹, Kohei Nomura², Kaoru Onda², Daisuke Suzuki², Yuuki Murase², Masahito Inagaki², Haruka Hiraoka², Naoko Abe², Fumitaka Hashiya², Yasuaki Kimura², Hiroshi Abe^2,3 (1. Department of science, Nagoya University, 2. Graduate School of Science, Nagoya University,, 3. iGCORE)

[Lang.] Japanese

10:30 AM - 10:40 AM

[D1441-4am-09] Activation of siRNA Triggered by Copper Ion Accumulated in Cancer Cells

^○Yasuhiro Tomida¹, Kunihiko Morohiro¹, Akimitsu Okamoto¹ (1. The Univ. of Tokyo)

[Lang.] Japanese

10:40 AM - 10:50 AM

[D1441-4am-10] Efficiency of stepwise reaction by enzymes assembled on a shape-transformable 3D DNA nanostructure

^○Mei Nakabayashi¹, Peng Lin¹, Nakata Eiji¹, Morii Takashi¹ (1. Kyoto University)

[Lang.] Japanese

10:50 AM - 11:00 AM

[D1441-4am-11] Detailed Analysis of DNA-Scaffolded Bioluminescence Energy Transfer System

^○Koichi Tanimoto¹, Tomoya Niki¹, Yuki Minamide¹, Shiori Tabana¹, Fumiaki Takano¹, Akinori Kuzuya¹ (1. Kansai Univ.)

[Lang.] Japanese

11:00 AM - 11:10 AM

[D1441-4am-12] Efficient Intramolecular Energy Transmission along DNA from Luciferase as intramolecular Excitation Energy sources.

^○Yuki Minamide¹, Koichi Tanimoto¹, Tomoya Niki¹, Shiori Tabana¹, Fumiaki Takano¹, Akinori Kuzuya¹ (1. Kansai Univ.)

[Lang.] Japanese

11:10 AM - 11:20 AM

[D1441-4am-13] DNA Origami as a Scaffold to Assemble Membrane Proteins on an Artificial Compartment

^○Shiwei Zhang¹, Eiji Nakata¹, Takashi Morii¹ (1. Kyoto university)

[Lang.] English

11:20 AM - 11:30 AM

[D1441-4am-14] Development of multidrug-integrated short-chain-nucleic acid drugs for effective chemotherapy of refractory cancer

^○Ryosei Komiyama¹, Kunihiko Morihiro¹, Akimitsu Okamoto¹ (1. The Univ. of Tokyo)

[Lang.] Japanese

11:30 AM - 11:40 AM

[D1441-4am-15] Left-handed quadruplex formation by the binding of mercury ion to thrombin binding aptamer

^○Yui Miyakara¹, Kohsei Sekiya¹, Jiro Kondo², Hidetaka Torigoe¹ (1. Tokyo University of Science, 2. Sophia University)

[Lang.] Japanese

Sessions

17. Biofunctional Chemistry, Biotechnology » Oral A

[D1441-1am] 17. Biofunctional Chemistry, Biotechnology

[D1411-1am] 17. Biofunctional Chemistry, Biotechnology

[D1411-1vn] 17. Biofunctional Chemistry, Biotechnology

[D1441-1vn] 17. Biofunctional Chemistry, Biotechnology

[D1411-2am] 17. Biofunctional Chemistry, Biotechnology

[D1441-2am] 17. Biofunctional Chemistry, Biotechnology

[D1411-2pm] 17. Biofunctional Chemistry, Biotechnology

[D1441-2pm] 17. Biofunctional Chemistry, Biotechnology

[D1411-2vn] 17. Biofunctional Chemistry, Biotechnology

[D1441-2vn] 17. Biofunctional Chemistry, Biotechnology

[D1411-3am] 17. Biofunctional Chemistry, Biotechnology