^○Yusuke Minami¹, Yoshiyuki Manabe¹, Risako Ono¹, Kotaro Hirao¹, Yuichi Umegawa¹, Michio Murata¹, Koichi Fukase¹ (1. Graduate School of Science, Osaka Univ.)

[Lang.] Japanese

9:40 AM - 9:50 AM

[D1442-1am-05] Development of fluorescence-labeled molecular probe for observing intracellular behavior of Mincle: Synthesis and biofunctional analysis

^○Juri Takayama¹, Kana Okubo¹, Takanori Matsumaru¹, Yukari Fujimoto¹ (1. Fac. Sci. Tech., Keio Univ)

[Lang.] Japanese

9:50 AM - 10:00 AM

[D1442-1am-06] Investigation of the significance and mechanism of [4+4] cycloaddition occurring in cancer cells

^○Takuma SEKIGUCHI¹, Hiromasa YOSHIOKA², Ambara Rachmat PRADIPTA¹, Katsunori TANAKA^1,2 (1. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory)

[Lang.] Japanese

10:00 AM - 10:10 AM

[D1442-1am-07] Functional polymer synthesis in cancer cells using uncatalyzed [4+4] cycloaddition

^○Shinji KAWAGUCHI¹, Ambara Rachmat PRADIPTA¹, Katsunori TANAKA^1,2 (1. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory)

[Lang.] Japanese

Break （10:10 AM - 10:20 AM）

10:20 AM - 10:30 AM

[D1442-1am-08] Cell-to-cell transfer of glycan-modified HSA triggered by light stimulus

^○Akari Mukaimine¹, Katsunori Tanaka^1,2 (1. RIKEN, Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory, 2. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering)

[Lang.] Japanese

10:30 AM - 10:40 AM

[D1442-1am-09] Development of photo-responsive fluorogenic probe using photochromic fulgimide

^○Kenji Torii¹, Sam Benson², Marc Vendrell², Yuichiro Hori³, Kazuya Kikuchi^1,4 (1. Osaka University, 2. The University of Edinburgh, 3. Kyushu University, 4. Immunology Frontier Research Center, Osaka University)

[Lang.] Japanese

10:40 AM - 10:50 AM

[D1442-1am-10] Development of an optical transcription regulation system using a caging-group free photoactivatable dye

^○Tatsuki Nonomura¹, Masafumi Minoshima^1,2, Kazuya Kikuchi^1,3 (1. Graduate School of Engineering, Osaka University, 2. JST PRESTO, 3. Immunology Frontier Research Center, Osaka University)

[Lang.] Japanese

10:50 AM - 11:00 AM

[D1442-1am-11] Cell-to-cell transfer of glycan-modified HSA triggered by chemical reaction

^○Kobayashi Tatsuya¹, Kenshiro YAMADA¹, Akari MUKAIMINE², Ambara Rachmat PRADIPTA¹, Katsunori TANAKA^1,2 (1. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory)

[Lang.] Japanese

11:00 AM - 11:10 AM

[D1442-1am-12] Development of Novel Photosensitizers based on Naphthol Moiety of Enediyne Antibiotic N1999A2

^○Minami Takahashi¹, Kotono Matsunaga¹, Tsugumi Kagaya¹, Daisuke Takahashi¹, Kazunobu Toshima¹ (1. Keio University)

[Lang.] Japanese

11:10 AM - 11:20 AM

[D1442-1am-13] Development of in situ screening method for actinomycetes secondary metabolites from colonies using Raman spectroscopy

^○Shunnosuke Suwa¹, Masahiro Ando², Nakashima Takuji², Shumpei Horii^1,3, Atsuko Matsumoto², Toyoaki Anai⁴, Haruko Takeyama⁵ (1. Grad. Sch. Adv. Sci. Eng., Waseda Univ., 2. Res. Org. Nano Life Innov., 3. CBBD-OIL, AIST-Waseda Univ., 4. Grad. Sch. Agri., Kyushu Univ., 5. Inst. Adv. Res. Biosyst. Dyn., Waseda Res. Inst. Sci. Eng., Waseda Univ.)

[Lang.] Japanese

11:20 AM - 11:30 AM

[D1442-1am-14] Inhibitory activity against lipopolysaccharide function by prostaglandin A₂ isolated from soft coral.

^○Tomoyuki Hoshina¹, Eika Mizuno¹, Junichiro Miyamoto¹, Kenji Matsuno², Osamu Ohno¹ (1. School of Advanced Engineering, Kogakuin University, 2. Faculty of Pharmacy, Yasuda Women’s University)

[Lang.] Japanese

Break （11:30 AM - 11:40 AM）

Academic Program [Oral A]

[D1443-1am] 16. Natural Products Chemistry, Chemical Biology

Wed. Mar 22, 2023 9:00 AM - 11:40 AM D1443 (1443, Bldg. 14 [4F])

Chair: Tomonari Tanaka, Yuta Maki

+Add all to schedule

9:00 AM - 9:10 AM

[D1443-1am-01] Synthetic Study of Glycosyl-Stem Cell Factor Using β-mercapto Norleucine

^○Rio Morimoto¹, Yuta Maki^1,2, Ryo Okamoto^1,2, Yasuhiro Kajihara^1,2 (1. Dept. Chem., Grad. Sch. Sci., Osaka Univ., 2. FRC, Grad. Sch. Sci., Osaka Univ.)

[Lang.] Japanese

9:10 AM - 9:20 AM

[D1443-1am-02] Synthetic study of cyclic RGD glycopeptides toward elucidating the function of glycans of glycopeptide-type glycoconjugates

^○Hisao Yamasaki¹, Yuta Maki^1,2, Yasuhiro Kajihara^1,2, Ryo Okamoto^1,2 (1. Graduate school of Osaka University, 2. FRC, Grad. Sch. Sci., Osaka Univ.)

[Lang.] Japanese

9:20 AM - 9:30 AM

[D1443-1am-03] Development of liquid phase glycopeptide synthesis towards EPO glycoforms

^○Tatsuya Moriguchi¹, Daichi Nakamura¹, Jui Wu¹, Yuta Maki^1,2, Ryo Okamoto^1,2, Yasuhiro Kajihara^1,2 (1. Dept. of Chem., Grad. Schl. Sci. Osaka university, 2. FRC, Grad. Schl. Sci. Osaka university)

[Lang.] Japanese

9:30 AM - 9:40 AM

[D1443-1am-04] Optimization of glycosylation with glycosyl fluoride by using machine learning

^○Changhao Dai¹, Yoshiyuki Manabe¹, Koichi Fukase¹ (1. Osaka Univ)

[Lang.] English

9:40 AM - 9:50 AM

[D1443-1am-05] Chemical synthesis of Pseudomonas aeruginosa lipid A containing α-hydroxy fatty acid

^○Hiromu Oku¹, Atsushi Shimoyama¹, Koichi Fukase¹ (1. Osaka University)

[Lang.] Japanese

9:50 AM - 10:00 AM

[D1443-1am-06] Synthetic study of sialyl N-glycan: Improving efficiency of glycosylation reactions by aggregation control

^○Kumpei Yano¹, Yoshiyuki Manabe¹, Koichi Fukase¹ (1. Graduate School of Science, Osaka University)

[Lang.] Japanese

10:00 AM - 10:10 AM

[D1443-1am-07] Development of disaccharide building blocks for efficient synthesis of cyclic oligosaccharides

^○Hirofumi Endo¹, Masaharu Ochi¹, Azadur Md Rahman¹, Tomoaki Hamada², Yasuhiko Muramoto², Norihiko Sasaki¹, Toshiki Nokami¹ (1. Tottori University, 2. Koganei Corporation)

[Lang.] Japanese

10:10 AM - 10:20 AM

[D1443-1am-08] Synthesis of cyclic dodecasacchirides by electrochemical glycosylation

^○Yui Ishisaka¹, Asuka Saito¹, Hiroto Komatsu¹, Akito Shibuya¹, Norihiko Sasaki¹, Toshiki Nokami¹ (1. Tottori University)

[Lang.] Japanese

Break （10:20 AM - 10:30 AM）

10:30 AM - 10:40 AM

[D1443-1am-09] Synthesis of Glycomonomer and its Polymerization for Development of Novel Glycosaminoglycans Synthetic Method

^○Yuto Nakanishi¹, Tomonari Tanaka¹ (1. kyoto Inst. Tech.)

[Lang.] Japanese

10:40 AM - 10:50 AM

[D1443-1am-10] Enzymatic glycosylation catalyzed by GH84 bacterial O-GlcNAcase

^○Rika Okuno¹, Takayuki Ohnuma², Tomonari Tanaka¹ (1. Kyoto Inst. Tech, 2. Kindai Univ.)

[Lang.] Japanese

10:50 AM - 11:00 AM

[D1443-1am-11] Importance of the C6 position of GlcNAc of the glycolipid MPIase essential for the membrane protein integration in Escherichia coli.

^○Tsukiho Osawa¹, Kohki Fujikawa¹, Youjung Han², Ken-ichi Nishiyama², Keiko Shimamoto¹ (1. Bioorg. Res. Inst, SUNTORY Foundation for Life Sciences, 2. Faculty of Agriculture, Iwate Univ)

[Lang.] Japanese

11:00 AM - 11:10 AM

[D1443-1am-12] Synthesis of D-arabinofuranosylated probes as the inhibitor against exo-β-D-arabinofuranosidase

^○Akihiro ISHIWATA¹, Kiyotaka Fujita², Katsunori Takaka^1,3, Yukishige Ito^1,4 (1. RIKEN, 2. Kagoshima Univ, 3. Tokyo Inst. Technol, 4. Osaka Univ)

[Lang.] Japanese

11:10 AM - 11:20 AM

[D1443-1am-13] Synthesis study of α(2,8) disialosides containing N-acetyl group and N-glycolyl group

^○Yutaka Takeuchi¹, Hiroshi Tanaka¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

11:20 AM - 11:30 AM

[D1443-1am-14] Development of 1,2-Diacetal Protecting Group with Trichloroethyl Groups and Its Application to Glycosylation

^○Kazuya Murakami¹, Hiroshi Tanaka¹ (1. Tokyo Institute of technology)

[Lang.] Japanese

11:30 AM - 11:40 AM

[D1443-1am-15] β Selective glycosylation of fructofuranosyl donors possessing a 1,2-diacetal protecting group.

^○Reita Watanabe¹, Hiroshi Tanaka¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

Academic Program [Oral A]

[D1442-1pm] 16. Natural Products Chemistry, Chemical Biology

Wed. Mar 22, 2023 2:00 PM - 3:40 PM D1442 (1442, Bldg. 14 [4F])

Chair: Minami Odagi, Takanori Matsumaru

+Add all to schedule

2:00 PM - 2:10 PM

[D1442-1pm-01] One hundredth Scale Natural Product Chemistry: Functional analysis of a terpene synthase from lycophytes using the CS method

^○Chieon Park¹, Takaaki Mitsuhashi², Makoto Fujita^1,2 (1. Grad. School of Engineering, The Univ. of Tokyo, 2. IMS)

[Lang.] Japanese

2:10 PM - 2:20 PM

[D1442-1pm-02] Discovery and structural analysis of metabolites of vitamin D₃ lactone by cytochrome P450

^○Kazuto Iijima¹, Ryota Sakamoto¹, Akiko Nagata¹, Yuka Mizumoto¹, Naoto Nakaya², Kaori Yasuda², Toshiyuki Sakaki², Seketsu Fukuzawa³, Masaki Takiwaki³, Yoshikuni Kikutani³, Minami Odagi¹, Masayuki Tera¹, Kazuo Nagasawa¹ (1. Tokyo University of Agriculture and Technology, 2. Toyama Prefectural University, 3. JEOL Ltd.)

[Lang.] Japanese

2:20 PM - 2:30 PM

[D1442-1pm-03] Synthetic study of tris-guanidine alkaloid of KB343

^○Toma Osawa¹, Hayate Ishizuka¹, Minami Odagi¹, Kazuo Nagasawa¹ (1. Graduate School of Engineering, Tokyo University of Agriculture and Technology)

[Lang.] Japanese

2:30 PM - 2:40 PM

[D1442-1pm-04] Synthetic Study of SB-203207

^○Hasumi Masato¹, Tsutsumi Tomohiro¹, Hayakawa Ichiro¹ (1. Nihon university)

[Lang.] Japanese

Break （2:40 PM - 2:50 PM）

2:50 PM - 3:00 PM

[D1442-1pm-05] Synthetic Studies on Terpenes with Hedgehog and Wnt Signaling Pathway Inhibitory Activities

^○Yuichi Orita¹, Suzuka Fujita¹, Yuichi Ishikawa¹ (1. Yokohama City University)

[Lang.] Japanese

3:00 PM - 3:10 PM

[D1442-1pm-06] Rapid Synthesis of Manzamine Alkaloidal Scaffolds via Regio-controlled Dimerization of Dihydropyridines

^○Toshiaki Wayama¹, Yuta Arai², Hiroki Oguri¹ (1. The University of Tokyo, 2. Tokyo University of Agriculture and Technology)

[Lang.] Japanese

3:10 PM - 3:20 PM

[D1442-1pm-07] Synthetic studies of triquinane-type sesquiterpenes by Nazarov cyclization

^○Mikoto Sekine¹, Miho Oga¹, Akihiro Ogura¹, Ken-ichi Takao¹ (1. Faculty of Science and Technology, Keio University)

[Lang.] Japanese

3:20 PM - 3:30 PM

[D1442-1pm-08] Studies toward the total synthesis of Funiculosin

^○Takaya Minami¹, Ryosuke Yamaguchi¹, Yu Saito¹, Naoto Zui¹, Keisuke Sato¹, Tkanori Matumaru¹, Shinsuke Inuki², Yukari Fujimoto¹ (1. Fci. Sci. Tech., Keio Univ., 2. Grad. Sch. Pharm. Sci., Kyoto Univ.)

[Lang.] Japanese

3:30 PM - 3:40 PM

[D1442-1pm-09] Synthetic Study of Terpenes with 5/8/5 Carbocyclic Skeleton

^○Yuki Yamamoto¹, Atsushi Nakayama¹, Tetsuro Shinada¹ (1. Osaka Metropolitan Univ.)

[Lang.] Japanese

Academic Program [Oral A]

[D1442-1vn] 16. Natural Products Chemistry, Chemical Biology

Wed. Mar 22, 2023 4:10 PM - 6:40 PM D1442 (1442, Bldg. 14 [4F])

Chair: Arihiro Iwasaki, Hiroyoshi Takamura

+Add all to schedule

4:10 PM - 4:20 PM

[D1442-1vn-01] Synthetic Study of 6-Chlorotetrahydrofuran Acetogenin

^○Aya Imakiire¹, Ayaka Aso¹, Aya Matsunaga¹, Isao Kadota¹, Hiroyoshi Takamura¹ (1. Okayama University)

[Lang.] Japanese

4:20 PM - 4:30 PM

[D1442-1vn-02] Synthetic Study of Mandelalide A

^○Haru Ando¹, Takuya Jinnouchi¹, Kenta Tanaka¹, Hiroyoshi Takamura¹, Isao Kadota¹ (1. Okayama University)

[Lang.] Japanese

4:30 PM - 4:40 PM

[D1442-1vn-03] Synthetic studies on quartromicins, part 1 : Concise synthesis of multi-substituted cyclohexene cores

^○Kohei Kamatani¹, Koichi Deyama¹, Keisuke Suzuki¹, Ken Ohmori¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

4:40 PM - 4:50 PM

[D1442-1vn-04] Synthetic studies on quartromicins, part 2 : Asymmetric construction of cyclohexene cores

^○Koichi Deyama¹, Kohei Kamatani¹, Keisuke Suzuki¹, Ken Ohmori¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

4:50 PM - 5:00 PM

[D1442-1vn-05] Synthetic Study on C-glycosyl quinochalcones isolated from safflower

^○Sotaro Yamane¹, Kohei Azami¹, Keisuke Suzuki², Ken Ohmori¹ (1. Department of Science, Tokyo Institute of Technology, 2. Institute of innovative,Tokyo Institute of Technology)

[Lang.] Japanese

5:00 PM - 5:10 PM

[D1442-1vn-06] Synthetic Study of Brominated Acetogens Featuring One-pot Transacetalization/Bromination

^○Hebert Sean¹, Kenta Tanaka¹, Ryo Yamaguchi¹, Shoji Kobayashi¹ (1. Osaka Institute of Technology)

[Lang.] Japanese

Break （5:10 PM - 5:20 PM）

5:20 PM - 5:30 PM

[D1442-1vn-07] Synthetic Studies on iriomoteolide-1a

^○Tomohiro Obana¹, Kazuki Nakazato¹, Hayato Nakagawa¹, Masashi Tsuda², Haruhiko Fuwa¹ (1. Chuo University, 2. Kochi University)

[Lang.] Japanese

5:30 PM - 5:40 PM

[D1442-1vn-08] Convergent total synthesis of muricatetrocin B

^○Riko Minami¹, Tsubasa Kasai¹, Haruhiko Fuwa¹ (1. Chuo university)

[Lang.] Japanese

5:40 PM - 5:50 PM

[D1442-1vn-09] Synthesis and structure-activity relationship of enigmazole A analogues

^○Kyoya Ohyama¹, Atsushi Yoshimura¹, Tomo Mori¹, Keita Sakamoto, Haruhiko Fuwa¹ (1. Chuo University)

[Lang.] Japanese

5:50 PM - 6:00 PM

[D1442-1vn-10] Total synthesis, conformational analysis, and cytotoxicity of exiguolide stereoisomers

^○Tomo Mori¹, Reika Murakami¹, Kei Iio¹, Haruhiko Fuwa¹ (1. Chuo University)

[Lang.] Japanese

6:00 PM - 6:10 PM

[D1442-1vn-11] Renovation Synthesis of Natural Products: Synthetic Study of Rare Natural Products from Commercially Available Natural Product

^○Tomohiro Tsutsumi¹, Kazuki Ichikawa¹, Ichiro Hayakawa¹ (1. Graduate School of Integrated Basic Sciences, Nihon University)

[Lang.] Japanese

6:10 PM - 6:20 PM

[D1442-1vn-12] Synthetic study of biselyngbyaside analogs

^○Yoshinobu Sakiyama¹, Arihiro Iwasaki¹, Kiyotake Suenaga¹ (1. keio univ)

[Lang.] Japanese

6:20 PM - 6:30 PM

[D1442-1vn-13] Isolation and structure determination of akunolides, new macrolide glycosides from a marine cyanobacterium

^○Kairi Umeda¹, Arihiro Iwasaki¹, Kiyotake Suenaga¹ (1. The Univ. of Keio)

[Lang.] Japanese

6:30 PM - 6:40 PM

[D1442-1vn-14] Isolation and Structure Determination of a New Madangolide Analog from Marine Cyanobacterium.

^○Masahiro Hagihara¹, Kiyotake Suenaga¹, Arihiro Iwasaki¹ (1. Keio University)

[Lang.] Japanese

Academic Program [Oral A]

[D1443-1vn] 16. Natural Products Chemistry, Chemical Biology

Wed. Mar 22, 2023 4:10 PM - 6:20 PM D1443 (1443, Bldg. 14 [4F])

Chair: Atsushi Minami, Fumitaka Kudo

+Add all to schedule

4:10 PM - 4:20 PM

[D1443-1vn-01] Biosynthetic Study of Aminoglycoside Antibiotic 4′-Deoxybutirosin

^○Aoi Sakamoto¹, Taichi Chisuga¹, Akimasa Miyanaga¹, Fumitaka Kudo¹, Tadashi Eguchi¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

4:20 PM - 4:30 PM

[D1443-1vn-02] Biosynthetic Study of Aminoglycoside Antibiotics Istamycin and Sporaricin

^○Rina Yasutomi¹, Fumitaka Kudo¹, Tadashi Eguchi¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

4:30 PM - 4:40 PM

[D1443-1vn-03] Structural and functional analysis of dehydrogenase HitM4 in the biosynthesis of macrolactam antibiotic hitachimycin

^○Mutsumi Ikezaki¹, Kazuma Tsuboi¹, Taichi Chisuga¹, Akimasa Miyanaga¹, Fumitaka Kudou¹, Tadashi Eguchi¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

4:40 PM - 4:50 PM

[D1443-1vn-04] Engineering of Adenylation Enzyme HitB in The Biosynthesis of Macrolactam Antibiotic Hitachimycin

^○Dawei Wang¹, Taichi Chisuga¹, Akimasa Miyanaga¹, Fumitaka Kudo¹, Tadashi Eguchi¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

4:50 PM - 5:00 PM

[D1443-1vn-05] Exploration and functional analysis of sesquiterpene biosynthetic genes based on comprehensive analysis of terpene synthase

^○Mizuki Kobayashi¹, Taro Ozaki¹, Masaru Hashimoto², Aiichiro Nagaki¹, Atsushi Minami¹, Hideaki Oikawa¹ (1. Hokkaido Univ, Fac. of Sci., 2. Hirosaki University, Fac.of Agric.Life Sci.)

[Lang.] Japanese

5:00 PM - 5:10 PM

[D1443-1vn-06] Mechanistic Studies on the Late-Stage Modification Enzymes in the Biosynthesis of Phomoidride B

^○Junya Takino¹, Shintaro Yamamoto¹, Taro Ozaki², Aiichiro Nagaki¹, Atsushi Minami¹, Hideaki Oikawa¹ (1. Hokkaido Univ. Fac. of Sci., 2. Tohoku Univ. Grad. Sch. of Pharm. Sci.)

[Lang.] Japanese

Break （5:10 PM - 5:20 PM）

5:20 PM - 5:30 PM

[D1443-1vn-07] Oxidative bicyclic ring formation involving indole diterpene biosynthesis

^○Yaping Liu¹, Taro Ozaki¹, Aiichiro Nagaki¹, Atsushi Minami¹, Hideaki Oikawa¹ (1. Fac. Sci., Hokkaido Univ.)

[Lang.] English

5:30 PM - 5:40 PM

[D1443-1vn-08] Total biosynthesis of melleolide produced by Basidiomycota fungi (2)

^○Mitsunori Fukaya¹, Miina Ozeki¹, Taro Ozaki¹, Aiichiro Nagaki¹, Atsushi Minami¹, Hideaki Oikawa¹ (1. Hokkaido University)

[Lang.] Japanese

5:40 PM - 5:50 PM

[D1443-1vn-09] Scalable Total Synthesis of Leucascandrolide A Macrolactone Using Chiral Phosphoric Acid Catalyst

^○Naoya Shinagawa¹, Shigenobu Umemiya¹, Masahiro Terada¹ (1. Graduate School of Science, Tohoku University)

[Lang.] Japanese

5:50 PM - 6:00 PM

[D1443-1vn-10] Synthesis and Biological Evaluation of Siladenoserinol A Analogues

^○Kohei Sasaoka¹, Kohei Hano¹, Yuki Hitora², Sachiko Tsukamoto², Masahito Yoshida¹, Hideo Kigoshi¹ (1. Degree Programs in Pure and Applied Sciences, University of Tsukuba, 2. Graduate School of Pharmaceutical Sciences, Kumamoto University)

[Lang.] Japanese

6:00 PM - 6:10 PM

[D1443-1vn-11] Isolation, synthesis, and biological activity of panaxcerol B, a nutrient starvation-selective cytotoxic compound.

^○Akine Kanakubo¹, Yuuki Nagaya¹, Kenji Matsuno², Osamu Ohno¹ (1. Kogakuin University, 2. Yasuda Women’s University)

[Lang.] Japanese

6:10 PM - 6:20 PM

[D1443-1vn-12] Isolation, synthesis and functional elucidation of new chitinase inhibitors isolated from hornets

^○Shunsuke Kasahara¹, Leo Kwon¹, Keisuke Hagiwara¹, Masahiro Kimura², Manabu Kato³, Shingo Kageyama³, Tomoki Ikuta³, Kenji Matsuno⁴, Osamu Ohno¹ (1. School of Advanced Engineering, Kougakuin University, 2. Iwate Medical University, 3. Yamada Bee Farm, 4. Faculty of Pharmacy, Yasuda Woman's University)

[Lang.] Japanese

Academic Program [Oral A]

[D1442-2am] 16. Natural Products Chemistry, Chemical Biology

Thu. Mar 23, 2023 9:00 AM - 11:30 AM D1442 (1442, Bldg. 14 [4F])

Chair: Takanori Matsumaru, Yousuke Takaoka

+Add all to schedule

9:00 AM - 9:10 AM

[D1442-2am-01] Search and mode of action studies on novel anti-inflammatory and anti-obesity substances of natural origin

^○Rina Hirai¹, Yuta Tsunematsu¹, Masaki Kita¹ (1. Nagoya University)

[Lang.] Japanese

9:10 AM - 9:20 AM

[D1442-2am-02] Chemical structure and bioactivity of new C₁₅-acetogenin from Laurencia spp. collected from the shore of Nikaho, Akita

^○Yu Minamida¹, Kenshu Fujiwara¹ (1. Grad. School Eng. Sci., Akita Univ.)

[Lang.] Japanese

9:20 AM - 9:30 AM

[D1442-2am-03] Biological Activities of Yessotoxin and Its Desulfo Derivative

^○Takuto Takeda¹, Takayuki Kawai¹, Nobuaki Matsumori¹ (1. Kyushu University)

[Lang.] Japanese

9:30 AM - 9:40 AM

[D1442-2am-04] Synthesis and immunomodulatory activities of endogenous glycolipids

^○Kazunari Ueki¹, Koudai Sueyoshi¹, Takanori Matsumaru¹, Sho Yamasaki^2,3, Yukari Fujimoto¹ (1. Faculty of Science and Technology, Keio University, 2. Research Institute for Microbial Diseases, Osaka University, 3. Immunology Frontier Research Center (IFReC), Osaka University)

[Lang.] Japanese

9:40 AM - 9:50 AM

[D1442-2am-05] Investigation of target proteins of anticancer saponin OSW-1

^○Myat Nyein Khine¹, Xin Lin², David Xiang Li², Kaori Sakurai¹ (1. Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2. Department of Chemistry, The University of Hong Kong)

[Lang.] English

9:50 AM - 10:00 AM

[D1442-2am-06] A novel electrophilic gold-nanoparticle probe using dichlorotriazine for affinity labeling

^○Ayaka Tsuruno¹, Shione Kamoshita¹, Kaori Sakurai¹ (1. Tokyo University of Agriculture and Technology)

[Lang.] Japanese

10:00 AM - 10:10 AM

[D1442-2am-07] Synthesis of Oligopyrrolidines by Iterative Assembly of Five-membered Lactams

^○Yasuki Soda¹, Kumpei Tatsumi¹, Shunsei Sato¹, Kana Shibuya¹, Noritaka Chida¹, Toshitaka Okamura¹, Takaaki Sato¹ (1. Keio University)

[Lang.] Japanese

Break （10:10 AM - 10:20 AM）

10:20 AM - 10:30 AM

[D1442-2am-08] Proteolysis-induced cancer treatment by cycloaddition reaction in cancer cells.

^○Ryoma Matsushima¹, Ambara Rachmat PRADIPTA¹, Katsunori Tanaka^1,2 (1. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory)

[Lang.] Japanese

10:30 AM - 10:40 AM

[D1442-2am-09] Activation of glycosyltransferase inhibitors triggered by cancer metabolites and its application for cancer therapy

^○Takatsugu Kasahara¹, Tsung-Che CHANG², Sayaka Urano², Ambara Rachmat PRADIPTA¹, Katsunori Tanaka^1,2 (1. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory)

[Lang.] Japanese

10:40 AM - 10:50 AM

[D1442-2am-10] On-site synthesis of cancer drug via in vivo amidation reaction.

^○Atsuhiro Matsuura¹, Ambara Rachmat Pradipta¹, Katsunori Tanaka^1,2 (1. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory)

[Lang.] Japanese

10:50 AM - 11:00 AM

[D1442-2am-11] Synthesis and Evaluation of Novel Fluorescence Probes for Visualization of Intracellular Redox

^○Sodai Higashida¹, Hidehumi Iwashita¹, Miyuu Kiyama¹, Kosei Shioji¹ (1. Fukuoka University )

[Lang.] Japanese

11:00 AM - 11:10 AM

[D1442-2am-12] Examination for the two-step perception model for the interaction between jasmonates and the co-receptor by Differential scanning fluorimetry

^○kotaro matsumoto¹, Misuzu Nakayama², Shunji Hoshino³, Jianxin Wang², Takuya Kaji², Yousuke Takaoka², Minoru Ueda^2,3 (1. Tohoku University, 2. Department of Chemistry, Graduate School of Science, Tohoku University, 3. Department of Molecular and Chemical Life Sciences)

[Lang.] Japanese

11:10 AM - 11:20 AM

[D1442-2am-13] Cancer on-site natural product synthetic study based on the intramolecular aza-electrocyclization

^○Kazuki Terashima¹, Ambara Rachmat Pradipta¹, Katsunori Tanaka^1,2 (1. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory)

[Lang.] Japanese

11:20 AM - 11:30 AM

[D1442-2am-14] Development of hydroxyl group deprotection mechanism triggered by endogenous acrolein

^○Yuria TAKAHASHI¹, Kazuki TERASHIMA¹, Ambara Rachmat PRADIPTA¹, Katsunori TANAKA^1,2 (1. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory)

[Lang.] Japanese

Academic Program [Oral A]

[D1442-2pm] 16. Natural Products Chemistry, Chemical Biology

Thu. Mar 23, 2023 2:00 PM - 3:40 PM D1442 (1442, Bldg. 14 [4F])

Chair: Kohei Fuchibe, Masahito Yoshida

+Add all to schedule

2:00 PM - 2:10 PM

[D1442-2pm-01] Construction of WYP-rich macrocyclic peptide library and comparison with conventional NNK library

^○Taiga Sumi¹, Tomoshige Fujino¹, Hiroshi Murakami^1,2 (1. Graduate School of Engineering, Nagoya University, 2. Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University)

[Lang.] Japanese

2:10 PM - 2:20 PM

[D1442-2pm-02] Total Synthesis of Antrimycins

^○Yusaku Tamura¹, Ibuki Fujiwara¹, Atsushi Nakayama¹, Tetsuro Shinada¹ (1. Osaka Metropolitan University)

[Lang.] Japanese

2:20 PM - 2:30 PM

[D1442-2pm-03] Synthetic Study of Cyclodepsipeptide Lagunamide C

^○Kazuki Hagimoto¹, Masahito Yoshida¹, Hideo Kigoshi¹ (1. Univ. of Tsukuba)

[Lang.] Japanese

2:30 PM - 2:40 PM

[D1442-2pm-04] Synthetic Study on Marine Cyclodepsipeptide Bouillonamide

^○Nene Takezawa¹, Masahito Yoshida¹, Hideo Kigoshi¹ (1. University of Tsukuba)

[Lang.] Japanese

2:40 PM - 2:50 PM

[D1442-2pm-05] Synthesis and biological evaluation of the cytotoxic cyclic depsipeptide destruxin E derivatives

^○Shione Kojima¹, Masahito Yoshida¹, Hideo Kigoshi¹ (1. Degree Programs in Pure and Applied Sciences, University of Tsukuba)

[Lang.] Japanese

2:50 PM - 3:00 PM

[D1442-2pm-06] Synthesis and Biological Activity of Pargamicin A Analogues

^○Tetsuya Inaba¹, Yuko Shibuya², Masayuki Igarashi², Masahito Yoshida¹, Hideo Kigoshi¹ (1. Degree Programs in Pure and Applied Sciences, University of Tsukuba, 2. Institute of Microbial Chemistry)

[Lang.] Japanese

3:00 PM - 3:10 PM

[D1442-2pm-07] Synthetic study of neodesmosine isolated from elastin and eggshell membrane

^○Kaho Oishi¹, Hiroto Yanuma¹, Toyonobu Usuki¹ (1. Sophia Univ.)

[Lang.] Japanese

3:10 PM - 3:20 PM

[D1442-2pm-08] Direct Amidation of Piperazic Acid and N-Hydroxy Amino Acid, and its Application for Total Synthesis of Dentigerumycin A

^○Kakeru Miyamoto¹, Taiki Morita^1,2, Hiroyuki Nakamura^1,2 (1. School of Life Science and Technology, Tokyo institute of Technology, 2. Laboratory for Chemistry and Life Science, Tokyo institute of Technology)

[Lang.] Japanese

3:20 PM - 3:30 PM

[D1442-2pm-09] Synthesis of Dipeptide Bioisosteres Using Regioselective Ring Opening of Difluorocyclopropanes

^○Masashi Mitsumori¹, Kohei Fuchibe¹, Junji Ichikawa¹ (1. Univ. of Tsukuba)

[Lang.] Japanese

3:30 PM - 3:40 PM

[D1442-2pm-10] Design and application of C-terminal protecting groups for fragment coupling reactions of protected peptides

^○Kengo Hada¹ (1. Yamagata University)

[Lang.] Japanese

Academic Program [Oral A]

[D1442-2vn] 16. Natural Products Chemistry, Chemical Biology

Thu. Mar 23, 2023 4:10 PM - 6:50 PM D1442 (1442, Bldg. 14 [4F])

Chair: Atsushi Nakayama, Hiroyoshi Takamura

+Add all to schedule

4:10 PM - 4:20 PM

[D1442-2vn-01] Chemoenzymatic Synthesis of drimane-8α,11-diols

^○Keita Ozawa¹, Seiya Endo¹, Daijiro Ueda², Tsutomu Sato², Atsushi Nakayama¹, Tetsuro Shinada¹ (1. Osaka Metropolitan Univ., 2. Niigata Univ.)

[Lang.] Japanese

4:20 PM - 4:30 PM

[D1442-2vn-02] Anti-inflammatory Effects of Limonoids from Chisocheton Plants in Inhibition of NF-κB Activation Pathway of LPS-stimulated THP-1 Cells

^○Erina Hilmayanti¹, Xuhao Huang ¹, Nurlelasari Nurlelasari³, Unang Supratman³, Kazuya Kabayama^1,2, Koichi Fukase^1,2 (1. Department of Chemistry, Graduate School of Science, Osaka University, Japan, 2. Forefront Research Center, Osaka University, Japan, 3. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Indonesia)

[Lang.] English

4:30 PM - 4:40 PM

[D1442-2vn-03] Synthetic Studies of Cephalotaxines using Dearomative Azaspirocyclization

^○Yota Uwabe¹, Kei Muto¹, Junichiro Yamaguchi¹ (1. Waseda university)

[Lang.] Japanese

4:40 PM - 4:50 PM

[D1442-2vn-04] Stereodivergent tandem synthesis of 2,5-cis and 2,5-trans-substituted pyrrolidines

^○Hayato Nakagawa¹, Haruhiko Fuwa¹ (1. Chuo university)

[Lang.] Japanese

4:50 PM - 5:00 PM

[D1442-2vn-05] Tandem synthesis of pyrrolidine and piperidine derivatives

^○Tatsumi Ishii¹, Haruhiko Fuwa¹ (1. Chuo University)

[Lang.] Japanese

5:00 PM - 5:10 PM

[D1442-2vn-06] Total Synthesis of Keramaphidin B

^○Takashi Noguchi¹, Yuki Kurihara¹, Ayane Okita¹, Minori Yagi¹, Haruka Yasufuku, Noritaka Chida¹, Toshitaka Okamura¹, Takaaki Sato¹ (1. Keio University)

[Lang.] Japanese

5:10 PM - 5:20 PM

[D1442-2vn-07] Development of Au-catalyzed azaspirocyclization: Total synthesis of fasicularin

^○Yuki Takatori¹, Ryohei Hanzawa¹, Haruhiko Fuwa¹ (1. Chuo University)

[Lang.] Japanese

5:20 PM - 5:30 PM

[D1442-2vn-08] Collective total synthesis of cylindricines

^○Ryohei Hanzawa¹, Haruhiko Fuwa¹ (1. Chuo University)

[Lang.] Japanese

5:30 PM - 5:40 PM

[D1442-2vn-09] Asymmetric Total Synthesis of Perhydrohistrionicotoxin

^○Yosuke Ono¹, Keisuke Nishikawa¹, Mitsuhiro Okumura¹, Yoshiki Morimoto¹ (1. Osaka Metropolitan University)

[Lang.] Japanese

5:40 PM - 5:50 PM

[D1442-2vn-10] Synthetic Study of Daphniyunnine C

^○Natsumi Yatsuzuka¹, Tomohiro Tsutsumi¹, Ichiro Hayakawa¹ (1. Graduate School of Integrated Basic Sciences, Nihon University)

[Lang.] Japanese

5:50 PM - 6:00 PM

[D1442-2vn-11] Four-step Total Synthesis of (±)-Eburnamonine

^○Yasukazu Sugiyama¹, Tshitaka Okamura¹, Takaaki Sato¹ (1. The Univ. of Keio)

[Lang.] Japanese

6:00 PM - 6:10 PM

[D1442-2vn-12] Development of approach to chiral fully substituted cyclic nitrones from amides

^○Sora Iwamoto¹, Ayako Tokuyama¹, Koya Takei¹, Shobu Hiraoka¹, Tsutomu Matsumoto¹, Noritaka Chida¹, Toshitaka Okamura¹, Takaaki Sato¹ (1. Keio University)

[Lang.] Japanese

6:10 PM - 6:20 PM

[D1442-2vn-13] Biomimetic direct syntheses of oxidized steroids included in mushrooms

^○Saki Nagayasu¹, Shoji Kobayashi¹ (1. Osaka Institute of Technology)

[Lang.] Japanese

6:20 PM - 6:30 PM

[D1442-2vn-14] Syntheses and anticancer activities of phytol derivatives

Gengo Kashiwazaki^1,2, ^○Yuma Yoshimoto¹, Kazuya Ashida¹, Marina Sumida², Satoru Hirabayashi², Izumi Doi², Tomohiro Itoh³, Toshiharu Hashizume⁴, Takashi Kitayama^1,2 (1. Graduate School of Agriculture, Kindai University, 2. Faculty of Agriculture, Kindai University, 3. Graduate School of Bioresources, Mie University, 4. Hagihara Farm Co., Ltd,)

[Lang.] Japanese

6:30 PM - 6:40 PM

[D1442-2vn-15] Synthetic Study of Sarcophytolide

^○Yuji Sugita¹, Isao Kadota¹, Hiroyoshi Takamura¹ (1. Okayama university)

[Lang.] Japanese

6:40 PM - 6:50 PM

[D1442-2vn-16] Synthetic study on hymenocardinol

^○Yu Ikemizu¹, Kanako Hanyu¹, Itaru SATO¹ (1. Graduate School of Sci. and Eng., Ibaraki Univ. )

[Lang.] Japanese

Academic Program [Oral A]

[D1443-2vn] 16. Natural Products Chemistry, Chemical Biology

Thu. Mar 23, 2023 4:10 PM - 6:50 PM D1443 (1443, Bldg. 14 [4F])

Chair: Takayuki Ohyoshi, Yoshio Ando

+Add all to schedule

4:10 PM - 4:20 PM

[D1443-2vn-01] Synthetic Studies on Proanthocyanidin A6 and Pavetannin B3

^○Keita Matsushima¹, Keisuke Suzuki¹, Ken Ohmori¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

4:20 PM - 4:30 PM

[D1443-2vn-02] Investigation of applications for flow synthesis of flavan oligomers

^○Naoki Narita¹, Keisuke Suzuki¹, Ken Ohmori¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

4:30 PM - 4:40 PM

[D1443-2vn-03] Synthetic study on C₂-symmetric (+)-catechin dimer

^○Nayuta Sonoda¹, Yusuke Kawada, Keisuke Suzuki¹, Ken Ohmori¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

4:40 PM - 4:50 PM

[D1443-2vn-04] Synthetic study on granaticin, a doubly-linked C-glycoside natural product

^○Takuya Yoshikawa¹, Yoshio Ando¹, Keisuke suzuki¹, Ken Ohmori¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

4:50 PM - 5:00 PM

[D1443-2vn-05] Total Synthesis of Pyranonaphthoquinone Antibiotic Nanaomycins

^○Sota Ajima¹, Taiju Hoshino¹, Yoshio Ando¹, Keisuke Suzuki¹, Ken Ohmori¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

5:00 PM - 5:10 PM

[D1443-2vn-06] Synthetic Study on Bicyclic Pyranonaphthoquinone Dimer, β-Naphthocyclinone

^○Taiju Hoshino¹, Yoshio Ando¹, Ken Ohmori¹, Keisuke Suzuki¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

5:10 PM - 5:20 PM

[D1443-2vn-07] Synthetic Study on γ-Rubromycin: Substituent Effect in Photochemical Reaction of Naphthoquinone

^○Daichi Ogawa¹, Yoshio Ando¹, Keisuke Suzuki¹, Ken Ohmori¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

Break （5:20 PM - 5:30 PM）

5:30 PM - 5:40 PM

[D1443-2vn-08] Synthetic Study of Aplyronine A toward Development of a Molecular Probe

^○Madoka Suzuki¹, Masahito Yoshida¹, Hideo Kigoshi¹ (1. University of Tsukuba)

[Lang.] Japanese

5:40 PM - 5:50 PM

[D1443-2vn-09] Development of Simplified Hybrids for the Structure-Activity Relationship Studies of Aplyronine A

^○Takahiro Hirano¹, Shota Konishi¹, Takayuki Ohyoshi¹, Hideo Kigoshi¹ (1. Degree Programs in Pure and Applied Sciences, University of Tsukuba)

[Lang.] Japanese

5:50 PM - 6:00 PM

[D1443-2vn-10] Synthetic Study of the LMNO Ring of Maitotoxin

^○Taishin Taniguchi¹, Yoko Yasuno¹, Tohru Oishi¹ (1. Kyushu university)

[Lang.] Japanese

6:00 PM - 6:10 PM

[D1443-2vn-11] Synthetic Study of the NOPQ Ring of Brevislucenal-F

^○Sho Kawamura¹, Kanako Toriyama¹, Yoko Yasuno¹, Masayuki Satake², Tohru Oishi¹ (1. Kyushu University, 2. The Univ. of Tokyo)

[Lang.] Japanese

6:10 PM - 6:20 PM

[D1443-2vn-12] Synthetic Study of Ladder-Shaped Polyethers Based on the Convergent Method via Three-Rings Construction

^○Ryoma Saito¹, Yoko Yasuno¹, Tohru Oishi¹ (1. Kyushu university)

[Lang.] Japanese

6:20 PM - 6:30 PM

[D1443-2vn-13] Synthetic Study of LL-Z1640-2 and Its Analogs

^○Rika Yamasaki¹, Hidemitsu Yamanaka¹, Atsushi Nakayama¹, Tetsuro Shinada¹ (1. Osaka Metropolitan University)

[Lang.] Japanese

6:30 PM - 6:40 PM

[D1443-2vn-14] Efficient Synthesis of Isocoumarin-3-carboxylic Acid Derivatives

^○Kenichiro Hamamoto¹, Atsushi Nakayama¹, Tetsuro Shinada¹ (1. Osaka Metropolitan University)

[Lang.] Japanese

6:40 PM - 6:50 PM

[D1443-2vn-15] Total Synthesis of Bipenicilisorin

^○Eigo Fukuda¹, Atsushi Nakayama¹, Tetsuro Shinada¹ (1. Osaka Metropolitan University)

[Lang.] Japanese

Academic Program [Oral A]

[D1442-3am] 16. Natural Products Chemistry, Chemical Biology

Fri. Mar 24, 2023 9:00 AM - 11:20 AM D1442 (1442, Bldg. 14 [4F])

Chair: Akio Ojida, Takuya Kaji

+Add all to schedule

9:00 AM - 9:10 AM

[D1442-3am-01] Development of Cysteine-selective Covalent inhibitors Utilizing β-Fluorovinylsulfonamides

^○Shunsuke Watanabe¹, Naoki Kawamoto¹, Yuya Hirose¹, Keisuke Tokunaga¹, Yudai Tanaka¹, Naoya Shindo¹, Akio Ojida¹ (1. Graduate school of Pharmaceutical Sciences, Kyushu university)

[Lang.] Japanese

9:10 AM - 9:20 AM

[D1442-3am-02] Development of orthogonal reversible protein labeling probes for multicolor imaging

^○Kohei Iijima¹, Shahi Imam Reja², Masafumi Minoshima^1,3, Kazuya Kikuchi^1,2 (1. Graduate School of Engineering, Osaka Univ., 2. Immunology Frontier Research Center, Osaka Univ., 3. JST PRESTO)

[Lang.] Japanese

9:20 AM - 9:30 AM

[D1442-3am-03] Mid-sized proteomimetics of KRas hypervariable region shows dual inhibition activity against KRas lipid modification

^○Naomi Horiuchi¹, Junko Ohkanda¹ (1. Instutution of Agriculture, Shinshu University)

[Lang.] Japanese

9:30 AM - 9:40 AM

[D1442-3am-04] In vivo synthesis of cancer therapy metal catalyst from blood albumin

^○Kyosuke IMAI¹, Kyohei MUGURUMA², Ambara Rachmat PRADIPTA¹, Katsunori TANAKA^1,2 (1. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory)

[Lang.] Japanese

9:40 AM - 9:50 AM

[D1442-3am-05] Catalytic olefin metathesis in blood

^○Tsung-Che Chang¹, Igor Nasibullin¹, Hiromasa Yoshioka¹, Akari Mukaimine¹, Katsunori Tanaka^1,2 (1. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory, 2. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering)

[Lang.] English

9:50 AM - 10:00 AM

[D1442-3am-06] Development of novel self-adjuvanting peptide-based vaccine using Glyco-Nanoadjuvants

^○Shiho Wada¹, Koki Murata², Haruka Ohara², Mayumi Niimura³, Mayuko Shimoda³, Masahiro Wakao², Yasuo Suda², Toshiro Moroishi^3,4, Hiroyuki Shinchi² (1. Fac. Eng., Kagoshima Univ., 2. Grad. Sch. Sci. and Eng., Kagoshima Univ., 3. Dept. Mol. and Med. Pharmacol., Fac. Life Sci., Kumamoto Univ., 4. CMRHA, Fac. Life Sci., Kumamoto Univ.)

[Lang.] Japanese

10:00 AM - 10:10 AM

[D1442-3am-07] Elucidation of the mRNA translational repression machinery by stabilizing 14-3-3-mediated protein-protein interactions

^○Nanami Ogino¹, Makoto Muroi², Hiroyuki Osada², Ken Matsumoto², Minoru Yoshida², Isao Kii¹, Junko Ohkanda¹ (1. Institution of Agriculture, Shinshu University, 2. RIKEN Center for Sustainable Resource Science, RIKEN)

[Lang.] Japanese

Break （10:10 AM - 10:20 AM）

10:20 AM - 10:30 AM

[D1442-3am-08] Cancer treatment in PDO and PDX models by therapeutic in vivo synthetic chemistry

^○Akiko Nakamura¹, Tsung-Che Chang¹, Akari Mukaimine¹, Katsunori Tanaka^1,2 (1. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory, 2. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering)

[Lang.] Japanese

10:30 AM - 10:40 AM

[D1442-3am-09] The effect of Maitotoxin on lipid membranes.

^○Midori Imada¹, Masanao Kinoshita¹, Keiichi Konoki², Nobuaki Matsumori¹ (1. Kyushu University, 2. Tohoku University)

[Lang.] Japanese

10:40 AM - 10:50 AM

[D1442-3am-10] Photoreactivity of trioxsalen derivatives for DNAs and preparation of trioxsalen-modified peptides

^○Kotono Hisatomi¹, Kazuhisa Fujimoto¹, Md Al Amin², Takanori Oyoshi² (1. Kyushu Sangyo University, 2. Shizuoka University)

[Lang.] Japanese

10:50 AM - 11:00 AM

[D1442-3am-11] Structures of DNA origami studied with scattered light imaging

^○Yaqi Zhang¹, Sooyeon Kim², Yuichi Taniguchi^1,2 (1. Kyoto University, 2. RIKEN)

[Lang.] English

11:00 AM - 11:10 AM

[D1442-3am-12] Synthesis and receptor affinity of the unidentified phytohormone Δ⁴-dn-iso-OPDA in Marchantia polymorpha.

^○Hidenori Yoshimatsu¹, Takuya Kagi¹, Gangqiang Yang², Nobuki Kato¹, Guillermo H Jimenez-Aleman³, Robert Solano ³, Minoru Ueda^1,4 (1. Graduate School of Sciences, Tohoku University, 2. School of Pharmacy, Yantai University, 3. CNB-CSIC, 4. Graduate School of Life Sciences, Tohoku University)

[Lang.] Japanese

11:10 AM - 11:20 AM

[D1442-3am-13] Design and synthesis of cyclic peptides based on G4 binding proteins and their binding to G4

^○Kazuhisa Fujimoto¹, Tomoya Yamaguchi¹, Fukasawa Kaito², Oyoshi Takanori² (1. Kyushu Sangyo University, 2. Shizuoka University)

[Lang.] Japanese

Academic Program [Oral A]

[D1442-3vn] 16. Natural Products Chemistry, Chemical Biology

Fri. Mar 24, 2023 4:10 PM - 6:50 PM D1442 (1442, Bldg. 14 [4F])

Chair: Arihiro Iwasaki, Shimpei Sumimoto

+Add all to schedule

4:10 PM - 4:20 PM

[D1442-3vn-01] Structure and Bioactivity of Hedoamide, a New Linear Peptides from Marine Cyanobacteria

^○Naoaki Kurisawa¹, Arihiro Iwasaki¹, Ghulam Jeelani², Yulia Rahmawati², Tomoyoshi Nozaki², Kiyotake Suenaga¹ (1. Faculty of Science and Technology, Keio Univ., 2. Graduate School of Medicine, The Univ. of Tokyo)

[Lang.] Japanese

4:20 PM - 4:30 PM

[D1442-3vn-02] Synthesis and Evaluation of the Biological Activity of Saponin Derivatives Using All-nitrogenated Sugars

^○Ayaha Kage¹, Yuya Okuyama¹, Erina Kato¹, Tomoe Matagawa¹, Sayaka Kawano¹, Siro Simizu¹, Noritaka Chida¹, Toshitaka Okamura¹, Takaaki Sato¹ (1. Keio University)

[Lang.] Japanese

4:30 PM - 4:40 PM

[D1442-3vn-03] Iridium-Catalyzed Tertiary Amide-Selective Carbonyl Modification of Peptides

^○Kazunari Nakahara¹, Hiroshige Ogawa¹, Yoshito Takahashi, Tatsuya Mori, Risa Yoshii, Noritaka Chida¹, Toshitaka Okamura¹, Takaaki Sato¹ (1. The Univ. of Keio)

[Lang.] Japanese

4:40 PM - 4:50 PM

[D1442-3vn-04] Ribosomal Synthesis of Peptide Libraries Containing α-hydrazino acid and its Application to Drug Candidate Screening

^○Satomi Matsumoto¹, Takayuki Katoh¹, Hiroaki Suga¹ (1. The University of Tokyo)

[Lang.] Japanese

4:50 PM - 5:00 PM

[D1442-3vn-05] Development of hydrophobic anchor molecule for liquid-phase peptide synthesis

^○Shimpei Sumimoto¹, Ryou Yamada¹, Issei Sagou¹, Kazuki Nakamura¹, Masahiro Okada¹ (1. Kanagawa University)

[Lang.] Japanese

5:00 PM - 5:10 PM

[D1442-3vn-06] Structure-activity relationship study of peptide pheromone analogs with a geranylated tryptophan residue.

^○ryo yamada¹, masahiro okada¹, shinpei sumimoto¹, shigeki kobayashi¹, kotaro azuma¹, kazuki nakamura¹, issei sago¹ (1. kanagawa university)

[Lang.] Japanese

5:10 PM - 5:20 PM

[D1442-3vn-07] Synthetic study of Bacillus-derived peptide pheromone containing farnesyltryptophan residue.

^○Kazuki Nakamura¹, Masahiro Okada¹, Shimpei Sumimoto¹, Ryo Yamada¹, Issei Sago¹, Koutarou Azuma¹ (1. kanagawa university)

[Lang.] Japanese

5:20 PM - 5:30 PM

[D1442-3vn-08] Synthetic study on modified cyclic peptide Oscillatorin derived from Cyanobacteria.

^○Issei Sago¹, Masahiro Okada¹, Shimpei Sumimoto¹, Ryo Yamada¹, Kazuki Nakamura¹, Kotaro Azuma¹ (1. Kanagawa University)

[Lang.] Japanese

Break （5:30 PM - 5:40 PM）

5:40 PM - 5:50 PM

[D1442-3vn-09] Structure elucidation of protoaculeine B and aculeines by solid-phase total synthesis

^○Raku Irie¹, Sara Takaki¹, Ryoya Wakabayashi¹, Chisato Tani², Satoko Matsunaga³, Makoto Inai², Hitoshi Ouchi², Ryuchi Sakai⁴, Toshiyuki Kan², Masato Oikawa¹ (1. Yokohama City University, 2. University of Shizuoka, 3. National Institute of Technology, Hakodate Colledge, 4. Hokkaido University)

[Lang.] Japanese

5:50 PM - 6:00 PM

[D1442-3vn-10] Concise synthesis of artificial aculeine analogs based on click chemistry and evaluation of their bioactivities

^○Sara Takaki¹, Raku Irie¹, Ryoya Wakabayashi¹, Yumi Irie², Hiromi Watari³, Chisato Tani⁴, Satoko Matsunaga⁵, Makoto Inai⁴, Hitoshi Ouchi⁴, Toshiyuki Kan⁴, Ryuichi Sakai³, Kazuhiro Irie², Masato Oikawa¹ (1. Yokohama City University, 2. Kyoto University, 3. Hokkaido University, 4. University of Shizuoka, 5. National Institute of Technology, Hakodate College)

[Lang.] Japanese

6:00 PM - 6:10 PM

[D1442-3vn-11] Structual analysis of ATHOD the fatty amino acid and ATHOD-containing peptides Burkholdines and Occidiofungins

^○Rin Kainuma¹, Toma Kadowaki¹, Hiroyuki Konno¹ (1. The Univ. of Yamagata)

[Lang.] Japanese

6:10 PM - 6:20 PM

[D1442-3vn-12] Synthetic Study on the Proposed Structure of the Blue Pigment from the Green Mussel, Perna viridis

^○Tatsuya Kiuchi¹, Miho Sato¹, Shinnosuke Mori¹, Masaya Nakata¹, Yoko Saikawa¹ (1. Faculty of Science and Technology, Keio University)

[Lang.] Japanese

6:20 PM - 6:30 PM

[D1442-3vn-13] Establishment of a Selective Recovery Method for Lead Using Peptides Immobilized onto Resin

^○Shuhei Yoshida¹, Taichi Isozaki¹, Takaaki Tsuruoka¹, Kenji Usui¹ (1. Graduate School of Frontiers of Innovative Research in Science and Technology (FIRST), Konan university)

[Lang.] Japanese

6:30 PM - 6:40 PM

[D1442-3vn-14] Highly efficient cell penetration of Arg-rich peptides by microwave irradiation

^○Momo Hirata¹, Fumihiro Kayamori¹, Nobuhiro Nakanishi^2,3, Kenji Usui^1,2 (1. Graduate School of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 2. Beyond5G Donated Lectuers, Konan University, 3. DSP Research, Inc.)

[Lang.] Japanese

6:40 PM - 6:50 PM

[D1442-3vn-15] Observation of solution state behaviors on a metal–peptide β-barrel

^○Ryo Onozuka¹, Tomohisa Sawada^2,3, Makoto Fujita^1,4 (1. Grad. School of Engineering, The Univ. of Tokyo, 2. Lab. for Chem. & Life Sci., Tokyo Tech, 3. JST PRESTO, 4. IMS)

[Lang.] Japanese

Academic Program [Oral A]

[D1442-4am] 16. Natural Products Chemistry, Chemical Biology

Sat. Mar 25, 2023 9:00 AM - 11:20 AM D1442 (1442, Bldg. 14 [4F])

Chair: Masahumi Minoshima, Tomohiro Doura

+Add all to schedule

9:00 AM - 9:10 AM

[D1442-4am-01] Rational design of an orthogonal pair of diterpene glycoside fusicoccin and 14-3-3 protein

^○Kiriyama Hironaru¹, Ohkanda Junko¹ (1. Shinshu Univ.)

[Lang.] Japanese

9:10 AM - 9:20 AM

[D1442-4am-02] Bioactivity and bioactive form of cis-OPDA, plant hormone biosynthetic precursor

^○Tsumugi Kitajima¹, Rina Saito³, Yuho Nishizato², Misuzu Nakayama², Nobuki Kato², Yousuke Takaoka², Hidenori Yoshimatsu², Minoru Ueda^2,3 (1. Faculty of Sciences, Tohoku University, 2. Graduate School of Sciences, Tohoku University, 3. Graduate School of Life Sciences, Tohoku University)

[Lang.] Japanese

9:20 AM - 9:30 AM

[D1442-4am-03] Investigation of diazo compounds reactivity with a biotolerant metal catalyst

^○Koya Okumura¹, Ambara Rachmat Pradipta¹, Katsunori Tanaka^1,2 (1. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory)

[Lang.] Japanese

9:30 AM - 9:40 AM

[D1442-4am-04] Examination of Lewis acid-catalyzed reaction in vivo

^○Ren KUMAKURA¹, Ambara Rachmat PRADIPTA¹, Katsunori TANAKA^1,2 (1. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory)

[Lang.] Japanese

9:40 AM - 9:50 AM

[D1442-4am-05] Glycan chemical knock-in based on proximity labeling: application to cancer immune therapy

^○Takuya Matsumoto¹, Yoshiyuki Manabe^1,2, Koichi Fukase^1,2 (1. Osaka University graduate school of science, 2. Osaka University Basic Science Project Research Center)

[Lang.] Japanese

9:50 AM - 10:00 AM

[D1442-4am-06] Construction of N-containing heteroaromatics via photo-induced N-O cleavage

^○Yui Kaneyama^1,2, Okamura Hidenori^1,2, Iida Momoka^1,2, Kawamori Arisa^1,2, Nagatsugi Fumi¹ (1. IMRAM, Tohoku Univ., 2. Grad. Sch. Sci, Tohoku Univ.)

[Lang.] Japanese

Break （10:00 AM - 10:10 AM）

10:10 AM - 10:20 AM

[D1442-4am-07] Development of Glyco-Nanoadjunvats that consisted of gold nanoparticles co-immobilized with synthetic TLR9 ligand and sugar molecule

^○Koki Murata¹, Mayuko Shimoda², Toshiro Moroishi^2,3 (1. Grad. Sch. Sci. and Eng., Kagoshima Univ., 2. Dept. Mol. and Med. Pharmacol., Fac. Life Sci., Kumamoto Univ., 3. CMRHA, Fac. Life Sci., Kumamoto Univ.)

[Lang.] Japanese

10:20 AM - 10:30 AM

[D1442-4am-08] Synthetic study of anticancer molecules using gold-catalyst in brain

^○Moeri HARA¹, Yudai ODE¹, Sayaka URANO², Akari MUKAIMINE², Tsung-Che CHANG², Ambara Rachmat PRADIPTA¹, Katsunori TANAKA^1,2 (1. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory )

[Lang.] Japanese

10:30 AM - 10:40 AM

[D1442-4am-09] Conversion of biogenic cancer metabolites into an anticancer compound in living cells

^○Masayuki KAWAI¹, Ambara Rachmat PRADIPTA¹, Katsunori TANAKA^1,2 (1. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory)

[Lang.] Japanese

10:40 AM - 10:50 AM

[D1442-4am-10] Synthesis and evaluation of catechol derivatives as an amyloid-beta aggregation inhibitor

^○fusheng xu¹, miyu okada¹, hiroyuki konno¹ (1. The Univ. of Yamagata)

[Lang.] English

10:50 AM - 11:00 AM

[D1442-4am-11] Development of prodrugs using the Diels-Alder reaction in vivo

^○Kaito Hattori¹, Hiroyuki Michiba¹, Ambara Rachmat PRADIPTA¹, Katsunori Tanaka^1,2 (1. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory)

[Lang.] Japanese

11:00 AM - 11:10 AM

[D1442-4am-12] Development of bi-substrate mimicking FUT8 inhibitor for regulating core fucose function

^○Koki Hizume¹, Yoshiyuki Manabe¹, Mayu Yanagihara¹, Yohei Takakura¹, Satomi Kasahara¹, Koichi Fukase¹ (1. Graduate School of Science, Osaka University)

[Lang.] Japanese

11:10 AM - 11:20 AM

[D1442-4am-13] Development of protein labeling probes containing bioisostere to suppress nonspecific accumulation in organelles

^○Takuya Kamikawa¹, Kazuya Kikuchi^2,3, Yuichiro Hori¹ (1. Graduate School of Science, Kyushu University, 2. Graduate School of Engineering, Osaka University, 3. Immunology Frontier Research Center, Osaka University)

[Lang.] Japanese

Academic Program [Oral A]

[D1443-4am] 16. Natural Products Chemistry, Chemical Biology

Sat. Mar 25, 2023 9:00 AM - 10:30 AM D1443 (1443, Bldg. 14 [4F])

Chair: Haruki Mizoguchi, Keisuke Nishikawa

+Add all to schedule

9:00 AM - 9:10 AM

[D1443-4am-01] Development of convergent synthetic method toward natural products with bicyclo[3.2.1]octane core

^○Naochika Matsumaru¹, Haruki Mizoguchi¹, Akira Sakakura¹ (1. Okayama University)

[Lang.] Japanese

9:10 AM - 9:20 AM

[D1443-4am-02] Toward the biomimetic synthesis of grayanane diterpenoids

^○hidetoshi kamada¹, Haruki Mizoguchi¹, Akira Sakakura¹ (1. Okayama University)

[Lang.] Japanese

9:20 AM - 9:30 AM

[D1443-4am-03] Synthetic Studies of Zyzzamine B Based on [2+2+2] Cycloaddition

^○Tatsuya Hirohashi¹, Eri Takagi¹, Kenshu Fujiwara¹ (1. Akita University)

[Lang.] Japanese

9:30 AM - 9:40 AM

[D1443-4am-04] Detection of Aplyronines in Red Algae based on Characteristic MS² Fragment Ions

^○Eri Anshita¹, Yusuke Hioki², Sato Tatsuya³, Toyoki Iwao⁴, Masaki Kita² (1. School of Agricultural Sciences, Nagoya University, 2. Graduate School of Bioagricultural Sciences, Nagoya University, 3. Zakko Club, 4. Toba Fisheries Science Center)

[Lang.] Japanese

9:40 AM - 9:50 AM

[D1443-4am-05] Synthetic study of (-)-morphine using organocatalyst

^○Yutaro Hatano¹, Naoki Mori¹, Yujiro Hayashi¹ (1. Tohoku Univ.)

[Lang.] English

9:50 AM - 10:00 AM

[D1443-4am-06] Studies on Asymmetric Synthesis of Toxicodenane C

^○Tomoki Tsuruta¹, Shinnosuke Nakao¹, Keisuke Nishikawa¹, Yoshiki Morimoto¹ (1. Osaka Metropolitan University)

[Lang.] Japanese

10:00 AM - 10:10 AM

[D1443-4am-07] Studies on Asymmetric Total Synthesis of 6-epi-Tetrodotoxin

^○Keisuke Nishikawa¹, Yosuke Ono¹, Shinichiro Tamura¹, Yoshiki Morimoto¹ (1. Osaka Metropolitan University)

[Lang.] Japanese

10:10 AM - 10:20 AM

[D1443-4am-08] Total synthesis of aplysiasecosterol A, a marine 9,11-secosteroid

^○Hidetada Iizumi¹, Shu Hosono¹, Hikaru Tano¹, Takayuki Ohyoshi¹, Hideo Kigoshi¹ (1. Degree Programs in Pure and Applied Sciences, University of Tsukuba,)

[Lang.] Japanese

10:20 AM - 10:30 AM

[D1443-4am-09] Synthetic Studies of Callophycoic Acid A

^○Raia Sagasaki¹, Seiya Endo¹, Ryugo Nakamura¹, Akihiro Ogura¹, Ken-ichi Takao¹ (1. Faculty of Science and Technology, Keio University)

[Lang.] Japanese

Academic Program [Oral A]

[D1443-4pm] 16. Natural Products Chemistry, Chemical Biology

Sat. Mar 25, 2023 1:00 PM - 2:40 PM D1443 (1443, Bldg. 14 [4F])

Chair: Kaname Sasaki, Naoki Mori

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1:00 PM - 1:10 PM

[D1443-4pm-01] Synthesis and biological function of mannosyl inositol phospholipid compounds

^○Akifumi Ito¹, Yohei Arai¹, Kana Okubo¹, Etusko Nabika¹, Takanori Matsumaru¹, Yukari Fujimoto¹ (1. Fac. Sci. Tech., Keio Univ.)

[Lang.] Japanese

1:10 PM - 1:20 PM

[D1443-4pm-02] Environmentally Benign C- and N-Glycosylations Utilizing Solid Acids.

^○Ryota Matsumoto¹, Daisuke Takahashi¹, Kazunobu Toshima¹ (1. Keio University)

[Lang.] Japanese

1:20 PM - 1:30 PM

[D1443-4pm-03] Synthetic studies of ω-thioaspartyl tRNAs

^○Yuta Shinotsuka¹, Akihisa Ikehara¹, Tae Hirai¹, Kaname Sasaki¹ (1. Toho University)

[Lang.] Japanese

1:30 PM - 1:40 PM

[D1443-4pm-04] Mechanistic studies on β-stereoselective mannosylations using 2,6-lactone donors

Nanako Uesaki¹, Yuka Takizawa¹, Kazuki Tohda¹, Yusuke Hashimoto¹, ^○Kaname Sasaki¹ (1. Toho Univerisity)

[Lang.] Japanese

1:40 PM - 1:50 PM

[D1443-4pm-05] Synthesis and biological evaluation of C-linked Isomaltose derivatives

^○Riko Tanabe¹, Takahiro Moriyama¹, Makoto Yoritate¹, Hiroaki Matoba¹, Minori Numamoto², Naoki Kato², Go Hirai¹ (1. Grad. Sch. Pharm. Sci., Kyushu Univ., 2. Grad. Sch. Agric., Setsunan Univ.)

[Lang.] Japanese

1:50 PM - 2:00 PM

[D1443-4pm-06] Synthesis and biological activity of CHF-linked melibiosamine analogues

^○Natsuho Moritsuka¹, Noriaki Kiya¹, Makoto Yoritate¹, Hiroaki Matoba¹, Go Hirai¹ (1. Graduate School of Pharmaceutical Sciences, Kyushu University)

[Lang.] Japanese

2:00 PM - 2:10 PM

[D1443-4pm-07] Synthesis and biochemical evaluation of a novel type of maltose analogue

^○Yuusei Tokunaga¹, Kazuki Doi¹, Takahiro Ikazaki¹, Hiroaki Matoba¹, Makoto Yoritate¹, Go Hirai¹ (1. Grad. Sch. Pharm. Sci., Kyushu Univ.)

[Lang.] Japanese

2:10 PM - 2:20 PM

[D1443-4pm-08] Synthetic study of C-linked neotrehalose analogues

^○Rintaro Nakahashi¹, Takahiro Moriyama¹, Hiroaki Matoba¹, Makoto Yoritate¹, Go Hirai¹ (1. Grad. Sch. Pharm. Sci., Kyushu Univ.)

[Lang.] Japanese

2:20 PM - 2:30 PM

[D1443-4pm-09] Synthetic studies of cyclic peptides consisting of sugar amino acid

^○Momona Eguchi¹, Hiroaki Matoba¹, Makoto Yoritate¹, Go Hirai¹ (1. Grad. Sch. Pharm. Sci., Kyushu Univ.)

[Lang.] Japanese

2:30 PM - 2:40 PM

[D1443-4pm-10] Inhibition machinery of sialoglycans with 3-exomethylene functionality

^○Risa Maeda¹, Keiya Uezono¹, Hiroaki Matoba¹, Makoto Yoritate¹, Go Hirai¹ (1. Grad. Sch. Pharm. Sci., Kyushu Univ.)

[Lang.] Japanese

Sessions

16. Natural Products Chemistry, Chemical Biology » Oral A

[D1442-1am] 16. Natural Products Chemistry, Chemical Biology

[D1443-1am] 16. Natural Products Chemistry, Chemical Biology

[D1442-1pm] 16. Natural Products Chemistry, Chemical Biology

[D1442-1vn] 16. Natural Products Chemistry, Chemical Biology

[D1443-1vn] 16. Natural Products Chemistry, Chemical Biology

[D1442-2am] 16. Natural Products Chemistry, Chemical Biology

[D1442-2pm] 16. Natural Products Chemistry, Chemical Biology

[D1442-2vn] 16. Natural Products Chemistry, Chemical Biology

[D1443-2vn] 16. Natural Products Chemistry, Chemical Biology

[D1442-3am] 16. Natural Products Chemistry, Chemical Biology

[D1442-3vn] 16. Natural Products Chemistry, Chemical Biology